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Flashcards in Test 3 Deck (12)
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1

Sulfonamides

Interfere with bacteria folic acid production
Inhibit enzyme for PABA that makes folic acid
Bacteriostatic
Broad

2

Tetracyclines

Block the attachment of tRNA to the ribosome
Stops protein synthesis
Bacteriostatic
Broad

3

Quinolones

Affect DNA synthesis
Bind to topoisomerase or gyrase
Stops the unwinding and DNA replication
Bactericidal
Broad

4

Penicillins

Interferes with the synthesis of peptidoglycan
Stops the enzyme that catalyzes the crosslinking of peptide bonds to create the peptidoglycan mesh as the cell wall expands, resulting in cell lysis
Bactericidal
Some types are narrow, some are broad

5

Erythromycin (Macrolide)

Built of sugars
Prevents translocation
Stops protein synthesis
Bacteriostatic
Broad

6

Polymixin B

Disrupts cell membrane
Hydrophilic end
Hydrophobic end
Bactericidal
Narrow (Gram -)

7

Metronidazole

Damages DNA in anaerobic and microaerophilic bacteria
Yanks electrons from DNA backbone
Bactericidal

8

Cephalosporins

Interfere with peptidoglycan crosslinking
More chemically advanced than penicillin
3 generations
Bactericidal
Broad

9

Aminoglycosides

Streptomycin, gentamicin, azithromycin
Bind to 30s ribosomal subunit
Blocks initiation
mRNA is read incorrectly and prevents protein synthesis
Bactericidal
Broad

10

Rifampin

Interferes with/blocks transcription
Binds to RNA polymerase
Protein synthesis is halted
Bactericidal
Broad

11

Oxazolidinones

Blocks initiation of protein synthesis
Prevents 50S from binding to 30S subunit
Bactericidal
Broad

12

Chloramphenicol

Binds to 50S ribosomal subunit
Blocks peptide bond formation
Prevents translocation
Bacteriostatic
Broad