Test 3 Flashcards
(18 cards)
insult that causes damage or injury to a tissue
Noxious stimulus
pain resulting from a non-noxious stimulus
allodynia
exaggerated pain response to noxious stimulus
hyperalgesia
reduced pain response to a noxious stimulus
hypalgesia
lack of pain response to noxious stimulus
analgesia
Which type of pain requires direct activation of nociceptors in the periphery due to tissue damage?
nociceptive pain
if pain originates from injury to or involves the PNS or CNS, what type is it?
Neurologic pain
What are three peripheral mediators?
serotonin (5-HT), K, histamine
When levels of peripheral mediators increase, what occurs?
peripheral sensitization
Which fibers transmit fast pain? slow main? Which are myelinated?
Fast–A-delta fibers (myelinated)
Slow–C-fibers
What NT is released from the nociceptive afferent when it synapses in the dorsal horn grey matter? What receptor does it use?
Glutamate, NMDA
What are two types of theraputic interventions that can be given to assist with analgesia?
Mu agonist, NMDA antagonist
What is it called when there’s increased sensitivity to a noxious stimulus? What causes it?
Central sensitization;
1) increased levels of gluatamate
2) increased sensitivity of NMDA receptors
Which ascending tract carries nociceptive information to the brain?
Spinothalamic tract
Name two location os the endogenous analgesia system
Pons/medulla, dorsal horn spinal cord
What receptor type does the ENK neuron use?
Mu
In gate-control theory, an applied mechanical stimulus stimulates what fiber?
A-beta
How does the activated A-beta neuron decrease secondary pain?
Stimulates ENK interneuron which decreases activation of the projection neuron
