Test 3 Nucleotide Metabolism Flashcards
(26 cards)
importance of nucleotides
provide energy (ATP)
electron carriers (NADH,FADH2)
UDP & ADP glucose
signal transduction
nucleotides are divided into two groups called
purines and pyrimidines
what are the three pathways of creating nucleotide
purine, pyrimidine and salvage pathway
purine and pyrimidine pathway is built from
scratch
the salvage pathway is built from
recycled nucleotides
in purine pathway, how is ring synthesized
ring synthesized on ribose sugar
in pyrimidine pathway, how is ring synthesized
ring synthesized first and then attached to ribose sugar
to make a deoxyribonulceotide we must do what to the ribonucleotide
reduce the ribonucleotide
how do we get a PRPP
from ribose-5-phosphate
where does ribose 5 phosphate come from when used in the salvage pathways
salvage pathway
why do we use phosphorylase and not kinase in salvage pathway
not using ATP but we are using inorganic phosphate
in pyrimidine, where does N3 come from
glutamine
in pyrimidine, where does c4, ch5,6 and N1 come from
aspartate
where does CH2 come from in pyrimidines
bicarbonate
together both CH2 and N3 come from what in pyrimidines
carbamoyl phosphate
how do we get uridylate to thymidylate
reduction of ribo to deoxy
methylation of deoxy-uridylate to thymidylate
what molecule is used to transfer methyl group to thymidylate
tetrahydrofolate
in bacteria, pyrimidine control
what activates ATCase
ATP
in bacteria, pyrimidine control
what inhibits ATCase
increased CTP
what is the main factor in pyrimidine control
Aspartate transcarbamoylase
in purines, where do some of carbons come from
tetrahydrofolate
in purines, where do some of the N come from
glutamine, aspartate and glycine
what is the committing step in purine synthesis
prpp to 5-phosphoribosyl-1 amine
phosphoribosyl-1-amino goes to
imp
