Testicular Tumors Flashcards Preview

RENAL Pathology > Testicular Tumors > Flashcards

Flashcards in Testicular Tumors Deck (29):

The cells often have clear cytoplasm which contains (1).

1. glycogen refers to seminomas


They often contain areas of (1) and, unlike most malignancies at other body sites, they can be highly treatable even after metastasis to other tissues.

1. sheets of undifferentiated cells with areas of hemorrhage and necrosis refers to embryonal carcinoma


Immunostaining of the cytoplasm also often shows (1) which is a tyrosine kinase for which there is a targeted therapeutic agent.

1. activated c-kit refers to seminomas


Adolescent patients with (1) tumors can have puberty at an earlier age (precocious puberty).

1. Leydig cell


Because (1) tumors can secrete hormones (androgens, estrogen, corticosteroids) the patients can present with (2)

1. Leydig cell 2. gynecomastia.


The Leydig cells are usually (1) so they generally grow as (2)

1. interstitial (not part of tubules) 2. sheets of cells without a tubular or glandular structure.



Choriocarcinoma; Leydig cell tumor


(1) can also be found arising in the testis and can involve (2) and include tissues such as cartilage, hair, brain tissue, respiratory tissue, or even teeth.

1. Teratomas 2. ectoderm, mesoderm, or endoderm


The trophoblast tissue expresses (1) which can also be present at elevated levels in the blood.

1. beta human chorionic gonadotropin (Beta hCG) refers to Choriocarcinomas of the testis


(1) is the most common subtype of non-seminoma germ cell tumor.

1. Embryonal carcinoma


Seminomas are more likely to occur in patients with?

cryptorchism or undescended testicle.


Hallmark of Leydig cell tumor

Crystals of Reinke


The most common type of germ cell malignancy is the (1) which are tumors with the histological appearance of (2) surrounded by (3) which are infiltrated by (4)

1. seminoma 2. nests or sheets of cells 3. fibrous bands 4. lymphocytes.


This subtype occurs in older men and only rarely metastasizes.

spermacytic seminoma


Most germ cell tumors are thought to arise from (1) cells which are a precursor to the germ cell lesions.

1. intratubal neoplastic


(1) are relatively rare NSGTs which characteristically show a histologic feature known as a Schiller-Duval body which is a (2)

1. Yolk sac tumors 2. capillary surrounded by an epithelial layer.


Although a rare neoplasm, it can be found in infants in whom it has a better prognosis than in older males.

Yolk sac tumors


The neoplasms have a placental morphology containing malignant trophoblast with both malignant syncytiotrophoblast and cytotrophoblast cells present.

Choriocarcinomas of the testis


(2) can present with (1) because the primary tumors frequently metastasize to the lung and invade the bronchus.

2. Choriocarcinomas of the testis 1. hemoptysis


Gynecomastia Lump/swelling in testicle Sexual precocity

Leydig cell tumor


Individuals with (1) have an increased risk of germ cell tumors, especially (2)

1. Klinefelter’s syndrome with the XXY genotype 2. seminoma.


Non-seminoma germ cell tumors (NSGT) can occur either as pure examples or as mixtures containing (1) along with another of the subtypes.

1. embryonal carcinoma


A subtype of seminoma known as (1) has the appearance of more mature spermatogonia and even spermatids.

1. spermacytic seminoma


The Sertoli cells are normally present within the (1) and their tumors sometimes reproduce the (2) structures but lack the normal (3), appearing instead as just groups of (4)

1. convoluted seminiferous tubules 2. tubular 3. interstitial cells 4. tubules without sperm development.


Most male testicular tumors are derived from (1) cells which is probably not surprising because they are cells which are destined to contribute to the formation of the entire body.

1. germ


These bodies can contain (1) which is also found at elevated levels within the blood of these patients.

1. alpha fetoprotein (AFP) found in Schiller Duval bodies found in yolk sac tumors


Gynecomastia Hemoptysis Increased hCG Hemorrhage and necrosis in tumor



Non-seminoma germ cell tumors (NSGT) include?

embryonal carcinoma, yolk sac tumors, choriocarcinoma, and teratomas.


1) and 2) do NOT arise from the precursor lesion called Intratubular germ cell neoplasia

Pediatric teratomas;

adult spermatocytic seminoma