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Flashcards in The autonomic NS Deck (28)
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1

what is the autonomic NS divided into

sympathetic
parasympathetic

2

how do the parasympathetic and sympthatic pass through the ganglia

para: pass through ganglia close to target organ
symp: pass through ganglia soon after spinal cord

3

what are the terminating transmitters for the parasymp and symp

para: acetylcholine
symp: norepinphrine

4

what is the main similiary btwn the para and symp system

use nicotinic cholinergic receptor at neuromuscular junction

5

what happens to the pupil in the parasymp response? symp?

para: pupil constricts
symp: pupil dilates

6

what are the 2 main types of receptors found in the ans

ionotropic: ion channels
metabotropic: GPCRs=> lead to a second messenger production

7

what are the 2 different families of receptors in the ANS

adrenergic recptors: all metabotropic (alpha1,2; beta1,2,3)

cholinergic receptors:
-nicotinic: ionotropic
-muscarinic: metabotropic

8

what are the endogenous ligans

ephinephrine and norepinephrine

9

what R group do norep, ephin, and Isoproterenol have

NE=H
Epi=Ch3
ISO=isopropyl group (CH(CH3)2)

10

what is the main difference of Epi and NE

NE has a very low potency while Epi has a high potentcy of the beta2 receptor (relaxatin of bronchial smooth muscle)

NE=safe to cause heart constriction w/o relaxation of the lungs

11

what is the antagonist of the beta2-receptor (relaxation of bronchia smooth muscle) and the beta 1-receptor (contraction of heart)

propranololol (beta antagonist-non selective)

12

what kind of shift determines if a drug is an antagonist

right shift

13

what do alpha-adrenergic receptors do

vasoconstriction of coronoary arteries
vasoconstriction of veins

14

what are alpha1 specific effects:
what are alpha2 specific effects:

alpha1: smooth muscle contraction
-stimulation = mydriasis
alpha2: inhibition of insulin release, contraction of sphincters, thrombocyte aggregation, negative feedback in neuronal synapses

15

what are beta 1 receptor effects
beta 2?
beta 3?

beta 1: inc cardiac output (inc HR), inc blood pressure
-inc contraction
-inc renin
beta 2: smooth muscle relaxation (mainly lungs)
-dilate arteries
-decrease histamine release from mast cells
-inc renin
beta3: enhancement of lipolysis in brown adipose tissue

16

what is the difference btwn clonidine and brimonidine

clonidine=does not vasoconstrict
brimonidine: casues vasoconstriction

17

what are the alpha2 selective adrenergic agonists
what are they used for

clonidine (doesnt vasocontrcit)
brimonidine (vasoconstricts)
-used in cardiovascular conditions to decrease BP and HR

18

what is isoproterenol selective for
what does it do

beta selective
increase bp and hr

19

what is NE and Epi seletive for

non-selective
NE is practically nonfunctional at beta2, only Epi

20

what is tetrahydrolozine selective for
what does it do

alpha agonist
constrict bv to reduce red eye

21

what are the alpha 1 agonists
what do they do

phenylephrine/pseudoephedrine
decongestant, contracts bv in nose when congested

22

what is albuterol selective for
what is it used for

beta 2 agonist
bronchodilation
asthma and covd

23

what is imipramine used for
what is the drug class

adrenergic reuptake inhibitor
anti-depressent
blocks reuptake transporter on pre synaptic cell to prevent NE from being taken from pre-synaptic space

24

what is the drug class of prazosin
what is it selective for
what does it do

alpha adrenergic agonist
alpha 1 selective
used to treat hypertension, contracts veins and arteries

25

what is the drug class of labetalol
what is it selective for
what does it do

beta-adrenergic antagonist
non-selective
blocks alpha1 receptor
used to lower bp during pregnancy

26

what is the drug class of propranolol
what is it selective for
what does it do

beta-adrenergic antagonist
non-selective
contracts bronchia smooth muscle, relaxes heart
treats hypertenstion, tremor, repeated heart attack

27

what is the class of physostigmine
what is its receptor
what does it do
what does it treat

-cholinesterase inhibitor
-ach agonist (reversible)
-increase conc of natural ach by inhibiting mech only where ach is released
-ach issues

28

what is the class of donepezil
what is its receptor
what does it do
what does it treat

-cholinesterase inhibitor
-ach agonist
-alzheimer's