The Citric Acid Cycle Flashcards
(20 cards)
Where does the CAC occur
In the mitochondrial matrix
Where does the CAC start and end
With oxaloacetate
What does amphibolic mean
Means that a reaction can be both anabolic and catabolic depending on cellular conditions
What kinds of cellular conditions do amphibolic pathways depend on
- Oxidation of fuel molecules (catabolic)
- Synthesis of metabolic intermediates (anabolic)
What makes the citrate synthase reaction exergonic
How many steps are in this process
Breaking of a thioester bond
2
What is special about the last three reactions of CAC
It turns a methylene of succincte into a carbonyl group
How is FADH2 reoxidized
By donating electrons to Q (mobile electron carrier)
What complex in the ETC is succincte dehydrogenase a part of
Complex 2
Is Q a co-substrate or a prosthetic group
Co-substrate
What part of the CAC rarely to never builds up?
Citrate
Does Ca2+ activate or inhibit alphaketogluterate?
It activates it
What is an anapleurotic reaction
Give 2 examples of these reactions
It is a reaction that replenishes citric acid cycle intermediates
1. Amino acid break down
2. Pyruvate decarboxylase
What is pyruvate carboxylase allosterically activated by?
Acetyl-CoA
What two substances can participate in making a lot of acetyl coma
- Fatty acids
- Amino acids
True or False: The CAC is not an amphibolic pathway
FALSE it IS an amphibolic pathway
How many ATP does each round of the CAC make
How many ATP does a complete round of aerobic oxidation of glucose make
10 ATP
32 ATP
What happens to CAC when the ETC stops working
The cycle stops at pyruvate
What product does the catabolism of lactate create
What is the net production of ATP for this too
3 NADH
1 FADH2
1 GTP
Net of 15 ATP
What is a major driving force in the regulation of aerobic metabolism
The relative concentration of ADP in the matrix
What happens to glycolysis if there is an uncoupled present
Everything speeds up because the Body can not make enough ATP
