The Fibrinolytic System: DIC (Part 2) Flashcards Preview

Hemostasis/Coag > The Fibrinolytic System: DIC (Part 2) > Flashcards

Flashcards in The Fibrinolytic System: DIC (Part 2) Deck (25):
0

What is the consequence of uncontrolled formation and deposition of fibrin?

Leads to thromboses

1

What are six coag components consumed in clotting?

II, I, V, VIII, XIII, and platelets

2

What is the consequence of the secondary activation of the fibrinolytic system?

Leads to bleeding

3

What five coagulation components are digested by plasmin?

I, V, VIII, XIII, and fibrin

4

What is the clinical presentation of DIC?

Multiple site bleeding, epistaxis, hematuria, oozing from intravascular sites, petechiae/purpura, and renal failure (due to free HGB)

5

What is the treatment for DIC?

treat underlying condition, FFP and/or platelet transfusions, heparin thearapy, and antifibrinolytic therapy (AMICAR)

6

Results of CBC with DIC?

schistocytes and decreased platelets

7

Results of a PT and APTT in DIC?

Prolonged PT and APTT

8

Results of a Fibrinogen in DIC?

Decreased

9

Results of a platelet count in DIC?

Decreased count

10

What are the 4 confirmatory tests for DIC?

TCT, Reptilase Test, FDP/FSP, D-Dimer

11

What are the results of a TCT in DIC?

Prolonged because it takes longer for fibrinogen to form a fibrin clot

12

Results of a reptilase time in DIC?

Prolonged, adding reptilase instead of thrombin to plasma

13

Results of FDP/FSP in DIC?

Positive; more split products and acts as an anti thrombin

14

Results for D-Dimer in DIC?

Positive; fibrinogen is influenced by XIII and DD's are left over

15

What are three conditions in which primary fibrinolysis may occur?

Open heart surgery, metastatic prostate cancer, and lightening strike patients

16

Blood smear
1 DIC
2 primary fibrinolysis

1 schistos
2 no schistos

17

D-Dimer
1 DIC
2 primary fibrinolysis

1 positive
2 negative

18

Platelet count
1 DIC
2 primary fibrinolysis

1 decreased-consumed in clotting
2 normal

19

Blood smear
1 DIC
2 TTP

1 schistos
2 schistos

20

D-Dimer
1 DIC
2 TTP

1 positive
2 negative

21

Platelet count
1 DIC
2 TTP

1 decreased
2 decreased

22

PT
1 DIC
2 TTP

1 prolonged
2 usually normal

23

APTT
1 DIC
2 TTP

1 prolonged
2 usually normal

24

In TTP microthrombi are deposited through the body in microcirculation composed primarily of _______ , not fibrin like in DIC. This is PRIMARY hemostasis.

Platelets