Flashcards in Introduction to Hemostasis; Specimen collection Deck (78)
List the four major systems involved in maintaining hemostasis.
Plasma coagulation factors
Process by which the body (upon vessel injury) spontaneously stops bleeding & maintains blood in the fluid state within the vascular system.
Prevents blood loss from injuries by the formation of a thrombus, and re-establish blood flow during the healing process.
The process of clot formation
A blood clot within the vascular system; "platelet plug"
Also refers to the formation of a blood clot or thrombus, but usually considered to be an abnormal finding.
Name of the first system
Name of the second system
Name of the fourth system
Name of the third system
Plasma coagulation factors
Which system is responsible for primary hemostasis?
Platelets (2nd system)
Which system is responsible for secondary hemostasis?
Plasma coagulation factors (3rd system)
Breakdown of fibrin
Reduces blood flow to area of injury to minimize blood loss and also draws platelets close to the injured vessel wall.
Damaged endothelial cells secrete___________.
Von Willebrand (vWF) factor
What is activated by exposure of tissue thromboplastin/tissue factor (TF)?
Plasma coagulation system
Platelet adhesion, aggregation, and, secretion is necessary to form ______
What system is initiated it by TF (tissue thromboplastin)?
Plasma coagulation system/ "cascade"
What three consequences leads to the formation of fibrin?
Coagulation, inflammation, and tissue repair
List two stages of Hemostasis.
Primary and secondary hemostasis
What is the function of primary hemostasis?
Platelets interact with injured vessels (and other platelets) to seal the wound. and form a primary platelet plug.
Does primary hemostasis have short term or long term effect?
Short term - temporarily arrests bleeding
What two systems are associated with primary hemostasis?
Vascular intima and Platelets
What type of test is used to diagnose a defect in primary hemostasis?
What is the function of Hemostasis?
Thrombin generated via coagulation cascade, in turn, generate fibrin. and forms secondary hemostatic plug.
Does secondary hemostasis have short term or long term effect?
Long term- strengthens the platelets plug
What two systems are associated with secondary hemostasis?
Coagulation and fibrinolysis
What type of test is used to diagnose a defect in secondary hemostasis?
Briefly describe an overview of hemostasis... beginning with the initial damage to the blood vessel. and ending with fibrinolysis.
- Collagen exposed/vWF secreted..platelet adhesion
- ADP secreted from granules- platelet aggregation= 1* hemostasis
- platelet plug reinforced by fibrin= 2* hemostasis
- Thrombus dissolved by fibrinolytic system