Introduction to Hemostasis; Specimen collection Flashcards Preview

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Flashcards in Introduction to Hemostasis; Specimen collection Deck (78)
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1

List the four major systems involved in maintaining hemostasis.

Vascular system
Platelets
Plasma coagulation factors
Fibrinolytic system

2

Process by which the body (upon vessel injury) spontaneously stops bleeding & maintains blood in the fluid state within the vascular system.

Hemostasis

3

Prevents blood loss from injuries by the formation of a thrombus, and re-establish blood flow during the healing process.

Hemostasis

4

The process of clot formation

Coagulation

5

A blood clot within the vascular system; "platelet plug"

Thrombus

6

Also refers to the formation of a blood clot or thrombus, but usually considered to be an abnormal finding.

Thrombosis

7

Name of the first system

Vascular system

8

Name of the second system

Platelets

9

Name of the fourth system

Fibrinolytic system

10

Name of the third system

Plasma coagulation factors

11

Which system is responsible for primary hemostasis?

Platelets (2nd system)

12

Which system is responsible for secondary hemostasis?

Plasma coagulation factors (3rd system)

13

Define Fibrinolysis

Breakdown of fibrin

14

Reduces blood flow to area of injury to minimize blood loss and also draws platelets close to the injured vessel wall.

Vasoconstriction.

15

Damaged endothelial cells secrete___________.

Von Willebrand (vWF) factor

16

What is activated by exposure of tissue thromboplastin/tissue factor (TF)?

Plasma coagulation system

17

Platelet adhesion, aggregation, and, secretion is necessary to form ______

Platelet plug

18

What system is initiated it by TF (tissue thromboplastin)?

Plasma coagulation system/ "cascade"

19

What three consequences leads to the formation of fibrin?

Coagulation, inflammation, and tissue repair

20

List two stages of Hemostasis.

Primary and secondary hemostasis

21

What is the function of primary hemostasis?

Platelets interact with injured vessels (and other platelets) to seal the wound. and form a primary platelet plug.

22

Does primary hemostasis have short term or long term effect?

Short term - temporarily arrests bleeding

23

What two systems are associated with primary hemostasis?

Vascular intima and Platelets

24

What type of test is used to diagnose a defect in primary hemostasis?

Platelet tests

25

What is the function of Hemostasis?

Thrombin generated via coagulation cascade, in turn, generate fibrin. and forms secondary hemostatic plug.

26

Does secondary hemostasis have short term or long term effect?

Long term- strengthens the platelets plug

27

What two systems are associated with secondary hemostasis?

Coagulation and fibrinolysis

28

What type of test is used to diagnose a defect in secondary hemostasis?

Coag tests

29

Briefly describe an overview of hemostasis... beginning with the initial damage to the blood vessel. and ending with fibrinolysis.

-Vessel injury
- Collagen exposed/vWF secreted..platelet adhesion
- ADP secreted from granules- platelet aggregation= 1* hemostasis
- platelet plug reinforced by fibrin= 2* hemostasis
- Thrombus dissolved by fibrinolytic system

30

List 7 types of bleeds associated with a platelet or vascular defect. (problem with primary hemostasis).

Petechiae, Purpura, Epistaxis, Hematemesis, Menorrhagia, Telangiectasia and also mucosal bleeding