The Cascade System (PART 1) Flashcards Preview

Hemostasis/Coag > The Cascade System (PART 1) > Flashcards

Flashcards in The Cascade System (PART 1) Deck (21):
0

What are clotting factors that circulate in blood as distinct entities in an inactive form?

zymogens

1

What a factor becomes activated, it is referred to as what?

serine protease

2

What binds to a particular serine protease to stabilize and increase reactivity?

Cofactors

3

This Factor is a substrate for thrombin and polymerizes to form fibrin.

Factor I-Fibrinogen

4

This factor is a cofactor for II ---> IIa and is a part of the prothrombinase complex

Factor V-Labile factor

5

This factor is a cofactor for X --> Xa

VIII:C

6

This factor is a carrier protein for VIII:C and is needed for platelet adhesion to collagen.

vWF

7

This factor is a transglutaminase which converts loose hydrogen bonds of fibrin monomers to covalent bonds.

XIII-Fibrin stabilizing factor

8

This factor is a serine protease and a precursor to thrombin.

Factor II-Prothrombin

9

This factor is a serine protease and activates X and IX (in vivo).

Factor VII-Stabile Factor

10

This factor is a serine protease and with help of the cofactor VIIIa it converts X--->Xa

Factor IX-Christmas Factor

11

This factor is a serine protease that is a part of the prothrombinase complex which converts II--->IIa

Factor X- Stuart Prower Factor

12

This factor is a serine protease that converts IX-->IXa

Factor XI-Plasma Thromboplastin Antecedant

13

This factor is a serine protease (in vivo) that is activated in the presence of HMWK and PK to activate XI-->XIa

Factor XII-Hageman Factor

14

This factor is a serine protease (in vivo) and with the help of cofactor HMWK it activates XI-->XIa

Factor PK- Fletcher Factor

15

This factor is a cofactor that participates in the (in vitro) contact activation of XI-->XIa and activates the Kinin System.

Factor HMWK- Fitzgerald Factor

16

Which factors are synthesized in the liver? (12 of them)

Factors I, V, VIII:C, XIII, II, VII, IX, X, XI, XII, PK, and HMWK

17

Which cofactors are synthesized in the endothelial cells and megakaryocytes?

vWF

18

Which enzyme is generated from the coagulation pathway that is needed to convert fibrinogen to fibrin?

Thrombin*

19

Which site provides the surface for the coagulation cascade?

PF3 (PL)

20

Initiation of coagulation by ______ is sufficient to initiate activation of both pathways.

TF or Factor VII complex