Flashcards in The Cascade System (PART 1) Deck (21)
What are clotting factors that circulate in blood as distinct entities in an inactive form?
What a factor becomes activated, it is referred to as what?
What binds to a particular serine protease to stabilize and increase reactivity?
This Factor is a substrate for thrombin and polymerizes to form fibrin.
This factor is a cofactor for II ---> IIa and is a part of the prothrombinase complex
Factor V-Labile factor
This factor is a cofactor for X --> Xa
This factor is a carrier protein for VIII:C and is needed for platelet adhesion to collagen.
This factor is a transglutaminase which converts loose hydrogen bonds of fibrin monomers to covalent bonds.
XIII-Fibrin stabilizing factor
This factor is a serine protease and a precursor to thrombin.
This factor is a serine protease and activates X and IX (in vivo).
Factor VII-Stabile Factor
This factor is a serine protease and with help of the cofactor VIIIa it converts X--->Xa
Factor IX-Christmas Factor
This factor is a serine protease that is a part of the prothrombinase complex which converts II--->IIa
Factor X- Stuart Prower Factor
This factor is a serine protease that converts IX-->IXa
Factor XI-Plasma Thromboplastin Antecedant
This factor is a serine protease (in vivo) that is activated in the presence of HMWK and PK to activate XI-->XIa
Factor XII-Hageman Factor
This factor is a serine protease (in vivo) and with the help of cofactor HMWK it activates XI-->XIa
Factor PK- Fletcher Factor
This factor is a cofactor that participates in the (in vitro) contact activation of XI-->XIa and activates the Kinin System.
Factor HMWK- Fitzgerald Factor
Which factors are synthesized in the liver? (12 of them)
Factors I, V, VIII:C, XIII, II, VII, IX, X, XI, XII, PK, and HMWK
Which cofactors are synthesized in the endothelial cells and megakaryocytes?
Which enzyme is generated from the coagulation pathway that is needed to convert fibrinogen to fibrin?
Which site provides the surface for the coagulation cascade?