The Physiology and Pharmacology of Eicosanoids Flashcards Preview

IMSK Exam 2 > The Physiology and Pharmacology of Eicosanoids > Flashcards

Flashcards in The Physiology and Pharmacology of Eicosanoids Deck (27):
1

What does phospholipase A2 do?

Cleaves Arachidonic acid from the cell membrane

2

What is derived from Arachidonic acid?

PG2 series each is a different physiologic mediator

3

What do prostaglandins work on (PG2)?

G protein receptors

4

What are imposters of prostaglandins?

Long-chain fatty acids (less pro-inflammatory)

5

What is a normal substrate for prostaglandins?

C20:4 Omega-6 FA

6

What does constitutive mean?

Levels fluctuates very little

7

What does inducible mean?

A stimulus to increase levels

8

Is COX-1 inducible or constitutive?

Constitutive

9

Is COX-2 inducible or constitutive?

Both

10

Is COX-3 constitutive or inducible?

Constitutive

11

What is a byproduct of COX and what can it cause?

Superoxide, inflammation

12

Where do antipyresis drugs work on COX-1/2?

In the CNS

13

Where do analgesic drugs work on COX-1 and 2?

COX-1 peripheral
COX-2/3 central

14

Aspirin 3 doses and usage?

Antiplatelet 81 mg/day
Antipyresis 325-650 mg every 4-6 hrs
Anti-inflammatory 3.2-6.0 g/day

15

How does aspirin affect the cox enzymes?

Irreversibly acetylates and inactivates COX-1 and COX-2

16

Why do you not administer aspirin to children and neonates?

Reyes Syndrome: causes fatty liver and encephalopathy; uncouples oxidative phosphorylation

17

When do you not administer aspirin?

Triad of nasal polyps asthma and aspirin allergy

18

How does ibuprofen work?

Inhibits COX-1 and COX-2

19

What is Indomethacin?

Very effective anti-inflammatory agent; short term use due to side effects (headache)

20

What does naproxen inhibit?

COX-1 and COX-2 enzymes

21

What can naproxen cause?

sudden death/MI in patients

22

What is the most effective analgesic?

Ketorolac; pure COX-1 inhibition

23

What are the side effects of ketorolac?

Major and significant risk for gastric injury; 5 day treatment course only

24

What does Tylenol-acetaminophen do?

Inhibit COX-3; not anti-inflammatory toxic to liver

25

What do non-selective COX inhibitors inhibit?

Thromboxane (COX-1 path) and Prostacyclin (COX-2 path)

26

What does selective COX-2 inhibitor affect?

Prostacyclin formation but leaves thromboxane intact

27

What does thromboxane cause in the GI tract?

Gastric mucin formation