Thrombocytopenia power points

Question 1

Causes of Thrombocytopenia

Answer 1

• Inherited
• Acquired
• Immune thrombocytopenia purpura (ITP)
• Thrombotic thrombocytopenia purpura (TTP)
• Heparin-induced thrombocytopenia (HIT)

Question 2

Immune Thrombocytopenic Purpura (ITP)

Answer 2

• Most common acquired thrombocytopenia
• Syndrome of abnormal destruction of circulating platelets
• Primarily an autoimmune disease

Question 3

Immune Thrombocytopenic Purpura (ITP)

Clinical syndrome manifests as:

Answer 3

• Acute condition in children
• Chronic condition in adults
• Women between 15 – 40 years of age
• Older adults
• Gradual onset with transient remissions
• Treated with multiple therapies

Question 4

Thrombocytopenia

Clinical Manifestations

Answer 4

• Patients are often asymptomatic.
• Most common symptom is mucosal or cutaneous bleeding.
• Petechiae – microhemorrhages
• Purpura – bruise from numerous petechiae
• Ecchymosis – larger lesions from hemorrhage
• Clinical Manifestations
  Prolonged bleeding after routine procedures
  Internal bleeding may manifest as weakness, fainting, dizziness, tachycardia, abdominal pain, or hypotension.
  Hemorrhage is a major complication.
  Insidious or acute
  Internal or external

Question 5

Thrombocytopenia

Answer 5

Diagnostic  Studies
↓ Platelet count
Prolonged bleeding < 50,000/μL 
Hemorrhage ↓ 20,000/μL 
Peripheral blood smear
Medical history
Clinical examination
Lab parameter comparisons