Thrombosis

Question 1

Name the natural anticoagulants

Answer 1

Protein C, S

Antithrombin III - blocks 10, 2, 7 , 9 , 11, 12

Question 2

What Lupus Anticoagulant

Answer 2

Prothrombotic in vivo - interact w phospholipids to enhance platelet adhesion, aggregation

Prolongs PTT

Question 3

Thrombus in Arteries vs Veins

Type
Cause
Complications

Answer 3

Arteries
- white thrombus - platelet rich

Veins
- red thrombus - fibrin w RBC

Causes: Rupture of atherosclerosis vs Stasis
Cx: MI, Stroke vs DVT, PE

Question 4

Whats Virchow’s Triad

Answer 4

Endothelial Damage
Stasis
Hypercoagulability

Question 5

Tests for VTE [2]

Answer 5

D-Dimer - elevated in many problems hence sensitive but not specific

• if negative - high true dont have VTE
• if positive - low specificity for VTE specifically

Compression Doppler Test
- if have clot, veins less collapse

Question 6

Steps for Investigations for PE

Answer 6

Check pre-test probability cos NPV of DDimer is inverse to prevalence;

• DDimer negative may be flawed if prevalence is high
• Wells criteria

if likely, prevalence is high, NPV is low - go for Scan

• V/P(Q) Scan
• CT Pulmonary Angiogram