Thymus gland Flashcards

1
Q

what type of organ is the thymus gland?

A

The thymus gland is a pink, lobulated lymphoid organ

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2
Q

where is the thymus gland located?

A

located in the thoracic cavity and neck

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3
Q

what is the function of the thymus gland in adolescent?

A

it is involved the development of the immune system

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4
Q

what happens to the thymus gland after puberty?

A

it decreases in size and is slowly replaced by fat

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5
Q

Embryologically, where is the thymus gland is derived from?

A

the third pharyngeal pouch

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6
Q

what type of shape & structure is the thymus gland?

A

The thymus gland has an asymmetrical flat shape, with a lobular structure

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7
Q

what are the lobules comprised of?

A

The lobules are comprised of a series of follicles, which have a medullary and cortical component

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8
Q

where is the cortical portion of the lobules located?

A

Located peripherally within each follicle

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9
Q

what is the cortical portion of the lobules composed of?

A

It is largely composed of lymphocytes, supported epithelial reticular cells

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10
Q

where is the medullary portion of each lobule located?

A

Located centrally within each follicle

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11
Q

What does the medullary portion of each lobule contain?

A

contains fewer lymphocytes than the cortex, and an increased number of epithelial cells

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12
Q

what else is present within the medullary portion of each lobule?

A

Hassall’s corpuscles are also present

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13
Q

what are Hassall’s corpuscles?

A

these are concentric arrangements of epithelial reticular cells. Their function is unclear

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14
Q

where is the thymus gland mainly located?

A

within the thoracic superior mediastinum, posterior to the manubrium of the sternum

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15
Q

where can the thymus gland extend to in some individuals?

A

it can extend superiorly into the neck (reaching the thyroid gland), and inferiorly into the anterior mediastinum (lying in front of the fibrous pericardium)

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16
Q

what is the arterial supply to the thymus gland via?

A

via the anterior intercostal arteries and small branches from the internal thoracic arteries

17
Q

where does venous blood drains into from the thymus gland?

A

Venous blood drains into the left brachiocephalic and internal thoracic veins

18
Q

what is DiGeorge syndrome?

A

a genetic syndrome caused by the deletion of part of chromosome 22. The clinical findings vary greatly between individuals

19
Q

how can the most common features of the syndrome can be memorised?

A

using the mnemonic ‘CATCH’

20
Q

what does ‘CATCH’ stand for in DiGeorge syndrome?

A
Congenital heart defects
Abnormal facies
Thymic aplasia
Cleft palate
Hypoparathyroidism
21
Q

what are individuals with an absent or asplastic thymus are susceptible to? why?

A

recurrent infections due to an underdeveloped immune system