TLRs - Innate Immunity Flashcards Preview

IHO Week 1 > TLRs - Innate Immunity > Flashcards

Flashcards in TLRs - Innate Immunity Deck (17):
1

What PAMPs and DAMPs does TLR1+ and TLR2 recognize?

PAMPs - Triacylated lipoproteins (Pam3CSK4) Peptidoglycans, Lipopolysaccharides
-Also, TLR2 responds to the DAMPs of TLR2+ & TLR6

2

What PAMPs and DAMPs does TLR2+ and TLR6 recognize?

PAMPs - diacylated lipoproteins (FSL-1)
DAMPs - Heat shock proteins (HSP 60, 70, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Hyaluronic Acid fragments)

3

What PAMPs and DAMPs does TLR3 recognize?

PAMPs - dsRNA (poly I:C), tRNA, siRNA
DAMPs - mRNA, tRNA

4

What PAMPs and DAMPs does TLR4 recognize?

PAMPs - Lipopolysaccharides (LPS), Paclitaxel
DAMPs - Heat shock proteins (HSP22, 60, 70, 72, Gp96), High mobility group proteins (HMGB1), Proteoglycans (Version, Heparin sulfate, Hyaluronic Acid fragments), Fibronectin, Tenascin-C

5

What PAMPs and DAMPs does TLR5 recognize?

PAMPs - Flagellin
DAMPs - none

6

What PAMPs and DAMPs does TLR7 recognize?

PAMPs - ssRNA Imidazoquinolines (R848), Guanosine analogs (Loxoribine)
DAMPs - ssRNA

7

What PAMPs and DAMPs does TLR8 recognize?

PAMPs - ssRNA, Imidazoquinolines (R848)
DAMPs - ssRNA

8

What PAMPs and DAMPs does TLR9 recognize?

PAMPs - CpG DNA, CpG ODNs
DAMPs - Chromatin IgG complex

9

What PAMPs and DAMPs does TLR10 recognize?

PAMPs - profilin- like proteins
DAMPs - NONE

10

What TLRs only produce Pro-inflammatory Cytokines (TNF-alpha, IL-6 and IL-12)?

TLR1+ & TLR2, TLR2+ & TLR6, TLR5, TLR10

11

What TLRs produce IFN-beta?

TLR3 (dsRNA Poly I:C) and TLR4 (LPS)

12

What TLRs produce IFN-alpha?

TLR7, TLR8 (ssRNA) & TLR9 (CpG-DNA)

13

What TLRs produce IFN-beta (via IRF3)?

TLR3 (dsRNA Poly I:C) and TLR4 (LPS)

14

What TLRs produce IFN-alpha (via IRF7)?

TLR7, TLR8 (ssRNA) & TLR9 (CpG-DNA)

15

What transcription factor does TLR3 and TLR4 turn on?

IRF3

16

What transcription factor does all TLRs turn on (especially TLR4, TLR1+ & TLR2, TLR2 & TLR6, TLR5)?

AP-1, p50 and p65

17

What transcription factor does TLR7, TLR8 and TLR9 turn on?

IRF7