Toxic plant principles - the misfits (Gossypol, Resins, Unclassified) Flashcards Preview

Final toxico KP > Toxic plant principles - the misfits (Gossypol, Resins, Unclassified) > Flashcards

Flashcards in Toxic plant principles - the misfits (Gossypol, Resins, Unclassified) Deck (25)
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1

Gossypol plant

Cotton seed

2

Gossypol MOA

Cardiotoxic and 2˚ liver damage

decreased male fertility by destroying seminiferous cells

binds protine, amino acids and iron

3

Gossypol CS

Monogastrics > ruminants

Chronic - cardiac toxicity, male infertility

4

What is a resin/resinoid?

A compound that is solid, semisolid, or brittle at room temperature

Diverse group of chemicals

5

Resin plants (3)

Milkweed, Marijuana, China Berry

6

Resin MOA

irritation of nervous or muscle tissue

7

Alsike and Red clover MOA

hepatotoxicity, 2˚ photosensitization - Horse

Large dose = hepatic encephalopathy

8

Alsike or red clover CS

lacrimation, photophobia, sloughing

(red clover pictured)

9

Avocado MOA

Cardiotoxic - goat, horse, rabbit, caged birds

Non-infectious mastitis and agalactia (NA in birds...)

10

Black walnut MOA

Ingestion of fresh shavings made from heartwood = laminitis

11

Forage induced photosensitization plants (3)

Moldy alfalfa, red clvoer, moldy wheat (NP)

12

Forage induced photosensitization MOA

liver damage = 2˚ photosensitization

13

Grapes and raisins MOA

Dogs - acute renal failure

14

Grapes and raisins CS

GI - vomiting, acute renal failure

15

Lily plants (2) and MOA

Easter lily, Day lily

Cats - nephrotoxicity

Cats/Dogs - GI irritation

16

Lily CS

GI, depression, Polyuria, anuria, death

17

Pigweed MOA

Nitrate, Soluble oxalate, and unknown

Acute nitrate - methemoglobinemia

Chonic nitrate - aboriton

Soluble oxalate - hypocalcemia, kidney damage

?? - tubular nephrosis

 

*ruminants, pigs, horses

18

Red maple MOA

Unknown (galic(?) acid) - hemolytic anemia, hemoglobinemia, heinz bodies

 

Due to oxidation of RBC? (theory)

Could lead to renal failure

19

Senna plant

coffee senna

20

Senna MOA

unknown myotoxin - skeletal m. myopathy and cardiomypathy

Anthrauinone glycoside - cathartic

*seed is most toxic

21

Senna CS

Diarrhea, muscle weakness, myoglobinemia, coffee colored urine

22

Yellow starthistle

Russian Knappweed

MOA

Equine nigropallidal encephalomalacia - Chewing Dz

Interacts with dopamine - death of dopamine receptors at the substantia nigra and globus pallidus

 

23

Yellow star thistle and Russian knappweed CS

Sudden onset - inability to eat or drink, head down, drowsiness with intermittent excitement

24

Macademia nut MOA

unknown - dogs

recover in 2 days

GI, locomotor, hyperthermia, pale mm.

25

Mechanical injury plants (3)

Cactus, Jimsonweed, Cocklebur (pictured)