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Toxic substances Flashcards

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1
Q

use against warfarin-resistant rodents.

Bromethalin
Mercury
Strychnine

A

Bromethalin

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2
Q

Bromethalin toxicity signs may develop ___ hours or
several days after ingestion and progress over a period of a week or longer.

4-8 hours
12-24 hours
8 to 12 hours
48-72 hours

A

8 to 12 hours

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3
Q

Treatment for Bromethalin toxicity?

A

Oral and/or IV medication.
Emesis and MD AC

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4
Q

ability to cause brain swelling, which can lead to severe neurological symptoms and death.

Bromethalin toxicity
Strychnine toxicity
Mercury toxicity

A

Bromethalin toxicity

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5
Q

its MOT involves uncouples mitochondrial oxidative phosphorylation?

Bromethalin toxicity
Strychnine toxicity
Mercury toxicity

A

Bromethalin toxicity

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6
Q

Strychnine is a highly toxic alkaloid; from the seeds of the ___ tree?

A

Strychnos nux-vomica

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7
Q

use as pesticide and as a performance enhancer in athletics.

Bromethalin
Mercury
Strychnine

A

Strychnine

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8
Q

A sign of strychnine poisoning characterized by spasms or involuntary contractions of the facial muscles, causing the mouth to be pulled back into a distorted and painful-looking grin.

A

Risus sardonicus (sardonic grin)

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9
Q

In MOT of Strychnine poisoning the ___ is inhibited that leads to the excessive firing of nerve impulses and subsequent convulsions.

GABA
Glycine
Glutamate

A

Glycine

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10
Q

a neurotoxin produced by the bacterium Clostridium botulinum.

A

Botulinum toxin

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11
Q

also know as “quicksilver”, it has high density, silvery appearance, and ability to conduct electricity.

Lead
Mercury
Silver

A

Mercury

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12
Q

Signs & Symptoms of Mercury Toxicity:
were there is a metallic taste, construction in throat,
difficulty of breathing, and tongue corroded

1st/2nd Phase

A

1st Phase

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13
Q

Signs & Symptoms of Mercury Toxicity:
were there is a loosing teeth, gingivitis, severe infection
in the mouth, ulcer.

1st/2nd Phase

A

2nd Phase

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14
Q

Fatal dose of Mercuric Fluoride: ?
Fatal period: ?

50mg for 30 mins
2.5mg-5mg for 3 days
1-2mg for 3-5 days

A

1-2mg for 3-5 days

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15
Q

Tx for Metallic mercury toxicity

Oral succimer (DMSA) or oral unithiol (DMPS)
IV unithiol (DMPS) or IM BAL
Succimer (DMSA) & N-acetylcysteine (NAC)

A

Oral succimer (DMSA) or oral unithiol (DMPS)

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16
Q

Tx for Organic mercury toxicity

Oral succimer (DMSA) or oral unithiol (DMPS)
IV unithiol (DMPS) or IM BAL
Succimer (DMSA) & N-acetylcysteine (NAC)

A

Succimer (DMSA) & N-acetylcysteine (NAC)

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17
Q

Tx for Inorganic mercury toxicity

Oral succimer (DMSA) or oral unithiol (DMPS)
IV unithiol (DMPS) or IM BAL
Succimer (DMSA) & N-acetylcysteine (NAC)

A

IV unithiol (DMPS) or IM BAL

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18
Q

This was used for warfarin-resistant rodents.

Bromethalin
Strychnine
Malathion

A

Bromethalin

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19
Q

Lethal oral dose of Caffeine

2-3g
10g
20-30g
50-60g

A

10g for adults

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20
Q

Lipid pneumonia is caused by

Mineral oil
Oxygen
Water
Carbon dioxide

A

Mineral Oil

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21
Q

This plant is commonly prepared as tinctures

Arnica
Aloe Vera
Lavender
Echinacea

A

Arnica

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22
Q

Used in Wilson’s disease

Succimer (DMSA)
Penicillamine
Deferoxamine

A

Penicillamine

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23
Q

What is Wilson’s disease?

a) A neurological disorder
b) A genetic disorder affecting copper metabolism
c) A viral infection of the liver
d) A respiratory condition

A

b) A genetic disorder affecting copper metabolism

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24
Q

How does Penicillamine work in the treatment of Wilson’s disease?

a) It stimulates the production of copper-binding proteins.
b) It inhibits the absorption of copper in the intestines.
c) It chelates excess copper and promotes its excretion from the body.
d) It enhances liver function to metabolize copper efficiently.

A

c) It chelates excess copper and promotes its excretion from the body.

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25
This substance is made from highly refined, purified, and processed petroleum
Mineral Oil?
26
Antidote for codeine poisoning Atropine Flumazenil N-acetylecysteine Naloxone
Naloxone ?
27
The name given to poisoning associated with this substance roughly translates to "it hurts" Mercury Strychnine Cadmium
Cadmium
28
This is an autosomal recessive genetic disorder of copper metabolism characterized by the excessive accumulation of copper in the liver, brain, kidneys, and cornea. Menkes Disease Wilson's Disease Minamata Disease Opisthotonos
Wilson's Disease
29
First used as a chemical weapon on a large-scale during World War 1 Chlorine gas Nitrogen Dioxide Ammonia
Chlorine gas
30
If the person's eye was contaminated with butyl acetate, generally, what is the recommended minimum flushing time? 15 minutes 20 minutes 30 minutes
15 minutes?
31
Plant source of Strychnine? Cannabis sativa Strychnos nux-vomica Opium poppy Erythroxylum coca
Strychnos nux-vomica
32
Which part of the Strychnos nux-vomica plant contains strychnine? a) Leaves b) Flowers c) Roots d) Seeds
d) Seeds
33
What is the common name for the tree species Strychnos nux-vomica? a) Strychnine tree b) Poison ivy c) Belladonna d) Deadly nightshade
a) Strychnine tree
34
Used to treat manic episodes of bipolar disorder. Lithium Mercury Thallium Isoniazid
Lithium?
35
How does lithium work in managing manic episodes? a) It increases the levels of dopamine in the brain. b) It enhances the effects of serotonin neurotransmitters. c) It stabilizes mood by affecting ion transport in nerve cells. d) It reduces the production of excess norepinephrine.
c) It stabilizes mood by affecting ion transport in nerve cells.
36
Scientific name of Castor plant? Mentha piperita Aloe vera Ricinus communis Eucalyptus globulus
Ricinus communis
37
Toxic constituent of Castor plant Castor oil Ricin Oleic acid Vitamin E
Ricin
38
What is the primary mode of toxicity of ricin from the Castor plant? a) Liver damage b) Neurological effects c) Kidney failure d) Inhibition of protein synthesis
d) Inhibition of protein synthesis
39
Which part of the Castor plant contains the highest concentration of ricin? a) Seeds b) Leaves c) Roots d) Stems
a) Seeds`
40
Antidote for Iron toxicity Activated charcoal Naloxone Deferoxamine Atropine
Deferoxamine
41
Toxic dose of Lithium
Blood concentration above 1.5 mmol/L?
42
Vitamin C is also known as Ascorbic acid Folic acid Niacin Riboflavin
Ascorbic acid
43
Form of Vitamin B12 that is used as an antidote for CN toxicity Methylcobalamin Cyanocobalamin Hydroxocobalamin Adenosylcobalamin
Hydroxocobalamin
44
Toxic dose of Iron Ingestion >5 mg/kg of body weight Ingestion >10 mg/kg of body weight Ingestion >20 mg/kg of body weight Ingestion >30 mg/kg of body weight
Ingestion >20 mg/kg of body weight
45
Used to treat severe hypokalemia associated with barium toxicity? Sodium bicarbonate Calcium gluconate Potassium chloride Magnesium sulfate
Potassium chloride
46
It produces its effects by the uncoupling of oxidative phosphorylation Cyanide 2,4-Dinitrophenol (DNP) Bromethalin Digoxin
Bromethalin ?
47
Route of exposure for Aluminum a) Inhalation b) Ingestion c) Dermal (skin) contact d) Injection
Ingestion ?
48
This element was found in insecticides, rodenticides, low temperature thermometers, and is used in cardiac imaging Mercury Barium Lead Gadolinium
Gadolinium ?
49
Antidote for Thallium poisoning Dimercaprol (BAL) N-acetylcysteine (NAC) Sodium nitrite Prussian blue
Prussian blue
50
How does hydroxocobalamin act as an antidote for cyanide toxicity? a) It binds to cyanide, forming a stable complex that can be excreted. b) It promotes the breakdown of cyanide into harmless byproducts. c) It neutralizes cyanide by releasing oxygen molecules. d) It inhibits the absorption of cyanide in the gastrointestinal tract.
a) It binds to cyanide, forming a stable complex that can be excreted.
51
Which electrolyte imbalance is commonly observed in cases of barium toxicity? a) Hyponatremia b) Hyperkalemia c) Hypocalcemia d) Hypokalemia
d) Hypokalemia
52
Barium toxicity is most commonly associated with the ingestion of which substance? a) Barium sulfate b) Barium carbonate c) Barium chloride d) Barium hydroxide
a) Barium sulfate
53
What is the recommended route of administration for potassium chloride in the treatment of severe hypokalemia associated with barium toxicity? a) Oral b) Intravenous c) Intramuscular d) Subcutaneous
b) Intravenous
54
Which organ system is primarily affected by Thallium poisoning? a) Central nervous system b) Respiratory system c) Cardiovascular system d) Gastrointestinal system
a) Central nervous system
55
Match the following toxic substances with their associated effects or conditions: Minamata Baritosis Wilson's disease Opisthotonos Aldrich-Mee's line Itai-itai disease Risus sardonicus Arsenic Mercury Cadmium Copper Strychnine Barium
Minamata: Mercury Wilson's disease: Copper Strychnine: Opisthotonos Strychnine: Risus sardonicus Arsenic: Aldrich-Mee's line Itai-itai disease: Cadmium Baritosis: Barium
56
Matching the toxic substances with their associated effects or conditions: Vitamin A Vitamin B9 Vitamin B12 Vitamin K Vitamin B1 Wernicke-Korsakoff Hemorrhage Pernicious anemia Megaloblastic anemia Hyperkeratosis
Vitamin A: Hyperkeratosis Vitamin B9: Megaloblastic anemia Vitamin B12: Pernicious anemia Vitamin K: Hemorrhage Vitamin B1: Wernicke-Korsakoff
57
Lithium is completely absorbed within 6-8 hours of ingestion. T/F
T
58
Cadmium belongs to IARC Group II. T/F
F it belongs to IARC Group I
59
Bromethalin toxicity targets the Peripheral Nervous System. T/F
F it affects the CNS
60
Bromethalin toxicity targets the Central Nervous System. T/F
T
61
Aluminum has a specific antidote. T/F
F
62
There is a specific antidote for toluene toxicity. T/F
F
63
Theophylline was once widely used to treat asthma. T/F
T
64
Amiloride is used for lithium toxicity. T/F
T
65
Gamma hydroxybutyrate is also known as "Date rape" drug. T/F
T
66
Vitamin B12 Deficiency: Macrocytic anemia. T/F
T
67
Which toxic substance is primarily responsible for causing Minamata disease? a) Lead b) Arsenic c) Mercury d) Cadmium
c) Mercury
68
Which organic mercury compound is known for its high toxicity? a) Methylmercury b) Ethylmercury c) Phenylmercury d) Dimethylmercury
a) Methylmercury
69
In cases of lead poisoning, the approximate half-life of lead in the human body is around 30 days. T/F
T
70
What is the blood lead level threshold that is associated with abnormal neurobehavioral effects? a) >10 mcg/dL b) >20 mcg/dL c) >30 mcg/dL d) >40 mcg/dL
d) >40 mcg/dL
71
What is the blood lead level threshold that is associated with lead edema? a) >10 mcg/dL b) >30 mcg/dL c) >50 mcg/dL d) >70 mcg/dL
d) >70 mcg/dL
72
What is the minimum oral toxic dose of soluble barium salts? a) 100 mg b) 200 mg c) 500 mg d) 1000 mg
b) 200 mg
73
In barium toxicity, potassium phosphate is used as specific antidote for hypophosphatemia? T/F
T
74
In barium toxicity, potassium chloride is used as specific antidote for symptomatic or severe hypokalemia. T/F
T
75
What is the primary cause of Menkes disease, a copper deficiency disorder commonly found in male infants? a) Lack of ATP7B gene b) Lack of ATP7A gene c) Lack of SLC31A1 gene d) Lack of CTR1 gene
b) Lack of ATP7A gene
76
Which of the following conditions is associated with the rapid onset of nausea and vomiting, along with characteristic blue-green vomit upon ingestion? a) Wilson's disease b) Menkes disease c) Hemochromatosis d) Porphyria
a) Wilson's disease

Toxicology (10 decks)

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