Toxicology Flashcards

(49 cards)

0
Q

Deals with the chemicals found in the workplace

A

Occupational toxicology

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1
Q

Concerned with the deleterious effects of chemical and physical agents on all organisms

A

Toxicology

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2
Q

Deals with the potentially deleterious impact of chemicals, present as pollutants of the environment to living organisms

A

Environmental toxicology

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3
Q

Concerned with the toxic effects of chemical and physical agents on living organisms especially in population and community within defined ecosystem

A

Ecotoxicology

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4
Q

Substance that occurs in the environment at least in part as a result of human activity in which has a deleterious effects on living organisms

A

Pollutants

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5
Q

The ability of a chemical agent to cause injury

A

Toxicity

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6
Q

The likelihood that injury will occur in a given situation or setting

A

Hazard

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7
Q

The only expected frequency of the occurrence of an undesirable effect arising from exposure to a chemical or physical agent

A

Risk

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8
Q

Three interacting components of ecotoxicology

A

Toxicants and poisons
Environment
Organisms

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9
Q

Routes of exposure

A

Industrial-inhalation
Atmospheric-inhalation
Pollutants of water and soil-oral ingestion

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10
Q

Single exposure occurring over 1-2 days

A

Acute

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11
Q

Long term exposure

A

Chronic

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12
Q

Environmental considerations

A

Degradability of the substance
Mobility through air, water and soil
Bioaccumulation
Biomagnification

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13
Q

Air pollutants

A

Carbon monoxide
Sulfur dioxide
Nitrogen oxides
Ozone

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14
Q

By product of incomplete combustion

A

CO

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15
Q

Generated by the combustion of sulfur containing fossil

A

SO2

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16
Q

Brownish irritant gas. Exposure to farmers

A

NO2

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17
Q

Bluish irritant gas occurs normally in the earth atmosphere.

Important absorbent of UV light

A

Ozone

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18
Q

Use as industrial solvents, degreasing agents and cleaning agents

A

Halogenated aliphatic hydrocarbon

  • carbon tetrachloride
  • chloroform
  • trichloroethylene
  • tetrachlorethylene
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19
Q

An intermediate in the synthesis of chemicals

20
Q

Aryl, carbocyclic or heterocyclic compunds containing chlorine substituents

A

Chlorinated hydrocarbon insecticide

21
Q

Used in human and veterinary medicine

A

Organophosphorus insecticides

22
Q

Inhibit acetylcholinesterase

A

Carbate insecticides

23
Q

Insecticides derived from natural sources

A

Botanical insecticides

24
Herbicide used for destruction of weeds
Chlorophenoxy herbicides
25
Most important agent of bipyridyl herbicide
Paraquat
26
Drugs used to prevent or reverse the toxic effects of a heavy metal on an enzyme or other cellular target
Chelating agent
27
Oily, colorless liquid with a strong metacarpan like odor. | Single agent treatment of acute poisoning by arsenic and mercury
Dimercaprol
28
Treatment for poisoning by antimony, arsenic and lead. For the treatment of children with blood kead concentration greater that 45ug/dL
Succimer
29
White crystalline, derivative of penicillin. | For treatment of poisoning with copper
Penicillamine
30
Penetrates cell membrane relatively poor and therefore chelates extracellular metal ions much more effectively than intracellular ions
EDTA
31
Has affinity to copper. | Useful in the treatment of Wilson disease
Trientine
32
For iron poisoning
Deferoxamine
33
Denotes the absorption, distribution, excretion, and metabolism of toxins
Toxicokinetics
34
Apparent volume into which a substance is distributed
Volume of distribution
35
Measure of volume of plasma that is cleared of drug per unit time
Clearance
36
Denotes the injurious effects of toxins on vital functions
Toxicodynamics
37
Initial management of the poisoned patients
Clear Airways Check Breathing Evaluate Circulation Assess Depression
38
Getting information and describing the environment where the toxic emergency occured and taking some evidence
History
39
Brief examination
Physical examination
40
Involves removal of toxins from the skin or GIT
Decontamination
41
Spontaneous reporting of adverse reactions
Pharmacovigilance
42
Chemical substances that are used in controlling malignancy
Chemotherapeutic agents
43
Refers to the range of activity of a compound
Antibacterial spectrum
44
Can affect wide variety of microorganisms
Broad spectrum antimicrobial drug
45
Drugs inhibit multiplication of the susceptible organisms
Bacteriostatic activity
46
Ability to kill microorganism
Bactericidal activity
47
Activity of combinations of antibiotics
Antibiotic synergism
48
Drugs would only harm the invading microbe
Selective toxicity