Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

CC2 lecture > Toxicology, Therapeutic Drug Monitoring and Drugs of Abuse > Flashcards

Toxicology, Therapeutic Drug Monitoring and Drugs of Abuse Flashcards

(74 cards)

Start Studying
1
Q

chemicals that are not normally found/produced by the body

A

Xenobiotics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Routes of exposure:

A

ingested, inhaled, or intradermal absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Local effects are most common in

A

Intradermal absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Wider range of circulation

A

Systemic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Toxic effects can be assessed by measuring:

A

ALT and GGT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Most affected organ in toxicology

A

Liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

single exposure with violent response - severe

A

Acute

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Multiple small dosage such as alcohol consumption

A

Chronic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

qualitative testing (presence or absence) (immunochromatography)

A

Screening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

high specificity and sensitivity (quantitative) (mass spectrometry: GCMS, LCMS, ICP-MS, AAS for metals)

A

Confirmatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

:movement of drugs and metabolites in the body in relation to time and administration

A

Toxicokinetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Useful method for screening and qualitative detection

A

24 hour urine specimen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Recommended volume for urine specimen

A

60 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Common preservative of urine

A

Concentrated acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Tube collection for most metals

A

Royal blue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tube collection for Lead

A

Tan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Prone to loss by metabolism

A

Mercury and arsenic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Dose of drug: concentration of the drug at which 50% of treated individulas will experience

A

ED50

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dose of drug in which 50% of individuals will experience toxic adverse effects

A

TD50

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Dose of drug in which 50% of individuals will result in mortality

A

LD50

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

CNS stimulator; elicits sense of excitement and euphoria

A

COCAINE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Half life of cocaine

A

4-7 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Urine metabolite of Cocaine

A

Benzoylecgonine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Clearance time of cocaine

A

3 days single use
up to 20 days for chronic use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Acute intoxication of cocaine
hypertension, arrythmia (tachycardia), and AMI
26
Oldest and most widely used Can cause intense euphoria and “a sense of well-being” Relaxing effect
Cannabinoids
27
Source of cannabinoids
Cannabis sativa
28
Metabolite of cannabinoids
Tetrahydrocannabinol (THC)
29
Half life cannabinoids
1 day if single use 3-5 days if chronic
30
Longest to be removed in the body
cannabinoids
31
Detection window of cannabinoids
5 days in a single use 4 weeks chronic
32
Crystal meth
Methamphetamine hydrochloride
33
party drug or tablet form of meth
3,4-methylenedioxymethamphetamine (MDMA or ecstasy)
34
Euphoria and Mental Alertnetss
Amphetamines
35
Half-life of Amphetamines
10 hours
36
Detection window of amphetamine
3 days
37
Effects of Amphetamines
CNS and Respiratory stimulation Anorexia Psychic stimulation and excitability Temporary increase in mental and physical activity
38
Administered to ADHD to prolong attention span
Adderall
39
Commonly known as “angel dust” or “angel hair”
PCP - phencyclidine
40
Metabolite of PCP
1(1-Phenylcyclohexyl)-4-hydroxypiperidine (PCHP) 4-Phenyl-4-(1-piperidinyl) cyclohexanol (PPC) 5-(N-1-phenylcyclohexyl)amino]pentanoic acid (PCAA)
41
PCP acts as
Analgesic anesthetic stimulant
42
Adverse effect of PCP
Stupor and coma
43
Opiates are derived from
Opium poppy plant
44
Modified natural forms of opiates
Heroin Hydromorphone (Dilaudid) oxyxodone (percodan)
45
Syntheti/More addicitve opiates
Meperidine (Demerol) Methadone (Dolophine) Propoxyphene (Darvon) Pentazocine (Talwin) Fentanyl (Sublimaze)
46
Adverse effects of opiates
respiratory acidosis due to depression of respiratory centers myoglobinuria increase in serum indicators of cardiac damage
47
Sedative: Barbiturates (SePhenPen)
Secobarbital Pentobarbital Phenobarbital
48
Sedatives: Benzodiazepines (LoDiChlo) / (VaLibAt)
Diazepam (Valium) Chlorodiazepoxide (librium) Lorazepam (ativan)
49
Enhanced by alcohol consumption
Sedatives
50
Not allowed to collect specimen for drug analysis
employer of client crime investigator complainant owner/administrator of establishment
51
Remote collection sites needs permit from
Bureau of Health Facilities and Services BHFS/CHD
52
Types of collection:
Single: 1 container Split: one time collection but two containers equal volume
53
Specimen container for urine
Urine: 30 or 60 ml, polyethylene bottle, wide mouth with screw cap
54
Specimen container for saliva
30 mL polyethylene bottle
55
Specimen container for blood
10 mL plain test tube
56
Specimen container for hair
Self-sealed transplant plastic bag
57
Specimen container for Sweat
BFAD approved sweat patch
58
Specimen container for tissue
screw capped plastic container
59
Minimum requirement for scalp hair
100 mg or equivalent
60
Minimum requirement for saliva
2mL single 1.5 and 0.5 split
61
Minimum requirement for Sweat
DOH cleared patch worn for 7 to 14 days
62
Minimum requirement for urine:
60 mL single 30 mL each spit sample
63
Minimum requirement for blood:
5 mL
64
procedure to account for the integrity of each specimen or aliquot by tracking and storage from point of specimen collection to final disposition of the specimen and its aliquot
Chain of custody
65
contain the following: all steps of collection, persons who handled the specimen, status and integrity of specimen, pertinent info
Custody and Control froms
66
Storage for urine
-20 deg C
67
Storage for hair
cool and dry place
68
Storage for saliva
deep frozen at leat -8 to -10 deg C
69
Storage for blood separated serum
immediate freeze at -20 deg C
70
Storage for tissue
macerated and frozen
71
Specimen retention: Negative
5 days
72
Specimen retention: Positive
Minimum of 15 days
73
Specimen retention judicial proceedings or upon request
up to a year
74
Test results are valid for
1 year from date of issue

CC2 lecture (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions