Training Flashcards
(79 cards)
What is the main basis for physiological adaptation?
Favourable changes in protein structure and quantity
Are proteins static in the body?
No, they are continually turned over or recycled
What determines the number and type of proteins produced?
Stress signals from internal and external stimuli. Can either reduce the breakdown or increase the production
What are the steps of protein production in response to stress?
- Stress signals activate signalling pathways
- Pathways activate transcription factors
- Transcription factors turn genes on/off to produce code for new proteins (mRNA)
- Ribosomes make proteins using mRNA from these genes
Name examples of stress signals that drive protein adaptation.
- Ca²⁺
- AMP/ATP ratio
- Mechanical tension
- ROS
- Heat
Why is signalling necessary for protein synthesis?
It initiates the transcription and translation processes
What else is required besides signalling to make proteins?
- Amino acids
- Usable DNA
- Nuclei
- Ribosomes
How long after a stimulus does mRNA peak?
Peaks within hours, returns to baseline by ~24 hours
How long does it take for new proteins to cause functional changes?
Typically takes weeks
Are adaptations the same for everyone?
No, individual differences are large
How does neural adaptation compare to muscular adaptation?
Neural adaptations occur faster and are retained longer
What are the main training parameters that influence adaptation?
- Intensity
- Duration
- Frequency
- Pattern of stress
What is needed for adaptive change to occur?
Sufficient strain and the presence of metabolic/structural precursors (enzymes, antioxidants, etc.)
What is the difference between stress and strain?
Stress is the stimulus; strain is the biological response to that stress
What factors modulate how an individual adapts to stress?
- Genotype & epigenetics
- Age
- Training & clinical status
- Nutrients & meds
- Motivation & resilience
- Ergogenic aids
What are novel stressors that can affect adaptation?
- Ischemia
- Pharmaceutical hormetics
- Vibration
- Antigens
- Cognitive demands
What are environment stressors that can affect adaptation?
- Medium and its velocity
- Thermal energy
- Air and vapour pressures
- Gravity
- Energy
- Water
- Protein
- Pathogens and pollutants
- Social
What types of strain affect cells during exercise?
- Mechanical tension
- Energy substrate depletion
- Reactive oxygen/nitrogen species (RONS)
- pH changes
- Temperature
- Hypoxia
- Cell volume shifts
- Cognitive and sensorimotor demands
What determines the nature and extent of adaptation?
- Exercise parameters (FITT)
- Personal factors (e.g., genes, age)
- Diet
- Interference from other stimuli
How do FITT variables affect adaptation?
They determine the type and intensity of stress signals, which shape the resulting adaptation
How do genetics influence adaptation?
Thousands of gene differences affect protein coding and adaptation potential
How does sex impact protein adaptation?
Through differences in anabolic hormones like testosterone and estrogen
How does age affect adaptation?
- Children have lower anabolic hormone levels
- Older adults have reduced cell signalling and increased inflammation
How does clinical status affect adaptation?
Some diseases can increase or decrease protein synthesis and affect connective tissue production