Transfusion therapy

Question 1

Whole blood major identification

Answer 1

Symptomatic anemia with large-volume deficit

Question 2

Red blood cells: RBCs (adenine-saline added), RBC pheresis major indication

Answer 2

Symptomatic anemia; red blood cell exchange transfusion

Question 3

Red blood cells: deglycerolized, washed mojor indication

Answer 3

IgA deficiency with anaphylactoid/ anaphylactic reaction
Severe allergic reactions, rare donors, symptomatic anemia; red blood cell exchange transfusion

Question 4

Red blood cells: leukocyte-reduced major indication

Answer 4

Symptomatic anemia
Febrile reactions due to leukocyte antibodies
Reduction of CMV transmission and HLA alloimmunization

Question 5

Platelets/apheresis platelets major indication

Answer 5

Bleeding due to thrombo- cytopenia or platelet function abnormality in- cluding antiplatelet drugs
Prevention of bleeding from marrow hypoplasia

Question 6

Platelets leukocytes reduced/apheresis platelets leukocytes reduced major indication

Answer 6

Same as platelets above
Prevention of febrile reactions, HLA alloimmunization and CMV infection

Question 7

Apheresis granulocytes major indication

Answer 7

Neutropenia with infection unresponsive to appropri- ate antibiotics

Question 8

Plasma (liquid) major indication

Answer 8

Initial treatment of patients
Undergoing massive transfusion

Question 9

Cryoprecipitate pooled/ cryoprecipitated AHF major indications

Answer 9

Hypofibrinogenemia
Factor XIII deficiency (Second line therapy for von Willebrand’s disease, hemophilia A, and uremic bleeding)

Question 10

Fresh-frozen plasma (FFP) major indication

Answer 10

protein deficiencies when no specific coagulation factor concentrates are available
TTP

Question 11

PF24
(Plasma frozen within 24 hours after phlebotomy) major indication

Answer 11

Clinically significant plasma protein deficiencies when no specific coagulation factor concentrates are available
TTP

Question 12

Thawed plasma major indication

Answer 12

Clinically significant defi- ciency of stable coagula- tion factors when no specific coagulation factor concentrates are available
TTP

Question 13

Thawed plasma, cryo- precipitate reduced major indication

Answer 13

TTP

Question 14

Deglycerolization removes plasma proteins.
Risk of allergic and febrile reactions reduced; increases oxygen-carrying capacity

Answer 14

Red blood cells: deglycerolized, washed

Question 15

Leukocyte reduction is achieved by filtration: (1) soon after collec- tion (prestorage) or (2) after varying periods of storage in the laboratory.

Answer 15

Red blood cells: leukocyte-reduced

Question 16

Improves hemostasis
Apheresis platelets may be HLA (or other antigen) selected.

Answer 16

Platelets/apheresis platelets

Question 17

Infectious diseases
Hemolytic, allergic, febrile reactions
TACO, TRALI, TA-GVHD

Answer 17

Apheresis granulocytes