TRANSPLANTATION IMMUNOLOGY

Question 1

act of transferring cells, tissues, or organs from one site to another, typically between different individuals

Answer 1

TRANSPLANTATION

Question 2

two basic problems

Answer 2

o Genetic variation between donor and recipient
o Recognition of genetic differences by a transplant recipient’s immune system that causes rejection of a transplanted
organ

Question 3

Types of Grafts

Answer 3

Autograft
Isograft
Allograft
Xenograft

Question 4

self-tissue transferred from one body site to another in the same individual

Answer 4

Autograft

Question 5

tissue transferred between genetically identical individuals

Answer 5

Isograft

Question 6

tissue transferred between genetically different members of the same specie

Answer 6

Allograft

Question 7

tissue transferred between different species

Answer 7

Xenograft

Question 8

• cause: genetic differences at the major histocompatibility complex

Answer 8

Graft Rejection

Question 9

• an immunologic response displaying the attributes of specificity, memory, and self-nonself recognition

Answer 9

Graft Rejection

Question 10

• generally a function of the T-cell arm of the immune response, though bystander cells are often recruited following the
  release of mediators from T cells

Answer 10

Graft Rejection

Question 11

• in unique circumstances (preimmunized recipients or recipients of grafts across a species barrier, xenotransplantation)
  antibody responses are important

Answer 11

Graft Rejection

Question 12

General Stages of Graft Rejection

Answer 12

1. Sensitization stage
2. Effector stage

Question 13

occurs shortly after transplantation when antigen-reactive lymphocytes of the recipient proliferate in response to alloantigens
on the graft

Answer 13

Sensitization stage

Answer 14

Sensitization stage

Question 15

Sensitization stage 2 types

Answer 15

Direct recognition
Indirect recognition