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derm > Trigger - Bullae > Flashcards

Trigger - Bullae Flashcards

1
Q

2/2 Autoantibodies of the IgG class that attatch to desmogleins and inhibit desmosomes from aiding in cell adhesions causing acantholysis

A

pemphigus

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2
Q

flaccid blisters on the skin with erosions on mucous membranes

A

pemphigus vulgaris

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3
Q

typically begins in the oral mucosa

A

pemphigus vulgaris

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4
Q

Pt presenting with mouth ulcers that burn. also reports recent nose bleeds and decreased oral intake which has lead to weakness, malaise, and weight loss. what could this possibly be?

A

pemphigus vulgaris mouth ulcers!

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5
Q

there is NO mucosal involvement in which pemphigus?

A

foliaceus

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6
Q

Biopsy at the edge of a blister showing (+) deposits of IgG

A

pemphigus

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7
Q

Direct immunofluorescence staining (DIF) of normal appearing skin adjacent to a lesion showing IgG and C3.

A

pemphigus

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8
Q

ELISA results shows a (+) a-Dsg1 but a (-) a-Gsg3. what is the diagnosis

A

Pemphigus foliaceus

if 3 is positive its always vulgaris

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9
Q

this diagnosis has a prodrome of pruritus, urticaria and papular lesions that lasts from weeks to months

A

bullous phemigoid

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9
Q

Interaction of autoantibody with BP antigen.

A

bullous phemigoid

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10
Q

large, tense, firm topped bullae with serous or hemorrhagic fluid that has a negative nikolsky sign

A

bullous phemigiod

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11
Q

Biopsy of perilesional skin showing linear IgG deposits or C3 along basement membrane.

A

bullous phemigoid

gold standard

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12
Q

direct immunoflorescence study is done to confirm what diagnosis

A

phemigoid diagnoses

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13
Q

Acute hypersensitivity reaction affecting the skin and mucous membranes

A

erythema multiforme

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14
Q

erythematous papular or urticarial lesions tha later become bullae that are pruritic and painful

A

erythema multiforme

can be serous or hemorrhagic

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15
Q

can present as corneal ulcers or anterior uveitis

A

erythema multiforme

16
Q

presents with fever, weakness, malaise, and fatigue

A

erythema multiforme

17
Q

this bullous disease is known to be bilateral and symmetrical

A

erythema multiforme

18
Q

A patient has bilateral symmetric vesicles that have appeared on his face and upper extremities. he denies fever or mucosal involvement. what is his diagnosis? how would you treat him?

A

MILD erythema multiforme

Tx: antihistamines, low dose topical CS, valcyclovir if viral

if there is a LITTLE mucosal involvement you can do HIGH dose steroid gel

19
Q

A pt has symmetric and bilateral vesicles and bullae that are widespread over his upper and lower extremities, chest and groin area. He reports fever and malaise. What is your diagnosis and tx.

A

Dx: major erythema multiforme

tx: IVF, magic swizzle, prednisone, burows solution wet compresses.

20
Q

Pt presents with bilateral vesicular lesions around the eyes and across the face. On ocular exam you see anterior uveitis. What is the diagnosis and treatment

A

Dx: major erythema multiforme

tx: concult oph immediatly
topical low dose steroids for vesicles on face

21
Q

when do you use daily antivirals

A

recurrent erythema multiforme

22
Q

what is the MCC of major erythema multiforme

A

drug reactions!

23
Q

what is the compound topical oral solution (magic swizzle/throat soothie) formula

A

1:1 viscous lido/benadryl/Maalox/(+/-) dexamethasone Swish, gargle, spit

24
Q

skin tenderness followed by target lesions with rapid confluence and a positive nikoslies sign.

A

SJS/TEN

25
Q

A patient has massive desquamation that has now progressed to sloughing of the epidermis. He has a fever and his HR is 134. what is the dx

A

EMERGENT SJS/TEN

fever, HR>120, sloughing = emergent

26
Q

Classify SJS, SJS/TEN, and TEN

A
27
Q

treated with prednisone + azothioprine

A

bullous phemigoid

also the treatment for phemigus vulgaris! (can also use cellcept instead of azothioprine for this one)

28
Q

Cytotoxic event caused by immune response destroying keratinocytes

A

SJS/TEN

29
Q

Non-adherent dressings for the eye made of saline and erythromycin ointment is used in what diagnosis

A

SJS/TEN with eye involvement

30
Q

Treated with IV steroids and IVIG

A

SJS/TEN

derm (16 decks)

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