trigger CV pharm

Question 1

slow rate of rise of AP and prolongs duration

Answer 1

Class 1a (Quinidine, procainamide, disopyramide)

Question 2

shorted AP (minimal depression of phase 0 upstroke)

Answer 2

Class 1b - lidocaine, mexiletine

Question 3

dissociates from channel with slow kinetics (no change in AP duration)

Answer 3

flexainide, propafenone

Question 4

works as an anticholinergic on SA and AV nodes.

increases SA nodal discharge rate and AV nodal conduction

Answer 4

quinidine

Question 5

proarrhythmic that can cause torsades via QT prolongation

Answer 5

quinidine, procainamide, disopyramide

Question 6

similar to quinidine but lacks anticholinergic activity

Answer 6

procainamide

Question 7

MC ADE is a clinical syndrome similar to SLE and MC use is WPW

Answer 7

procainamide

Question 8

Potent anticholinergic and negative inotrope

Answer 8

disopyramide

CI in pts w HFrEF

Question 9

CI in pts with HFrEF

Answer 9

Disopyramide

Question 10

can precipitate CHF and has anticholinergic effects such as dry mouth, UR, constipation and blurred vision

Answer 10

Disopyramide

Question 11

used for Ischemic tissue, primarily active fast sodium channels below the AV node

Answer 11

Lidocaine

Question 12

used with ventricular dysrhythmias, especially those associated with MI

Answer 12

lidocaine

Question 13

caution in hepatic impairement

Answer 13

lidocaine
dronedarone

Question 14

often combined with classes Ia and III for refractory ventricular dysrhythmias

Answer 14

mexiletine

this is the oral lidocaine like drug

Question 15

use of this medication is limited by its GI SEs

Answer 15

mexiletine

Question 16

slows conduction velocity in the purkinje and AV node

Answer 16

flecainide

MC use is afib/aflutter

propafenone too but propafenone as has a nonselective BB effect

Question 17

MC use is afib/aflutter

Answer 17

Flecainide

may cause rapid VT in someone w structural abnormalities

Question 18

may cause rapid VT in someone w structural abnormalities

Answer 18

flecainide

Question 19

this drug is not used alone

Answer 19

mexiletine

Question 20

slows conduction velocity in the purkinje fibers and AV node + mild non-selective BB effect.

Answer 20

propafenone (similar to flecainide)

class 1c

Question 21

lengthens PR and QRS which can lead to bradycardia or heart block. AVOID in structural heart disease

Answer 21

propafenone

Question 22

SE of metallic taste

Answer 22

propafenone

Question 23

Contraindicated in patients w structural heart disease

Answer 23

class 1c antiarrhythmics

(flecainide and propafenone)

Question 24

Decrease automaticity, prolong AV conduction, prolong refractory period

Answer 24

beta blockers

Question 25

mainly used to suppress ventricular dysrhythmias and SVTs

Answer 25

Beta blockers

Question 26

Block potassium channels and prolong repolarization, widening QRS and prolonging QT.

Answer 26

class III antiarrhythmics amiodarone, sotalol, dofetilide, dronedarone, ibutilide

Question 27

has characteristics of all 4 antiarrhythmic classes and works on all cells but is primarily a K+ channel blocker

Answer 27

amiodarone (class III)

Question 28

should be avoided in bradycardic patients but is also ok to use in LV dysfunction

Answer 28

amiodarone

Question 29

pts on this medication should get an annual CXR. why?

Answer 29

amiodarone it can build up and cause pulmonary toxicity

Question 30

can induce hyper or hypothyroidism. must check TSH Q 6 months

Answer 30

amiodarone. this is because it MIMICS IODINE!!!!

Question 31

blue/gray discoloration & photosensitivity

Answer 31

amiodarone (derm toxicity)

Question 32

CYP3A4 inhibitor: can potentiate warfarin and digoxin (doubles digoxin levels)

Answer 32

amiodarone

Question 33

Primarily a potassium channel blocker but also has non-selective BB properties (negative inotrope)

Answer 33

sotalol

Question 34

Prolongs AP and QT interval. mainly atrial focused

Answer 34

dofetilide

Question 35

MC ADE is torsades (must get EKG 2 hrs after every dose)

Answer 35

dofetilide

Question 36

Similar to amiodarone with less efficacy but less SEs also

Answer 36

dronedarone

Question 37

CI: Symptomatic CHF or recent decompensation, Permanent AF

Answer 37

dronedaron

Question 38

IV only used soley for afib/aflutter cardioversion. AVOID in LV dysfunction and lyte abnormalities

Answer 38

ibutilide/corvert

Question 39

a negative inotrope that decreases automaticity and AV conduction

Answer 39

Class IV antiarrhythmics (verapamil and diltiazem.)

Question 40

Inhibition of Ca channels in AV node and activates K+ channels. slows ventricular rate in Afib/aflutter and terminates AVNRTs

Answer 40

digoxin

Question 41

PR prolongation and ST segment depression

Answer 41

digoxin

Question 42

toxicity w coadmin of ABX

Answer 42

oral digoxin also has super poor bioavailability

Question 43

used to convert SVT to sinus rhythm

Answer 43

adenosine

Question 44

Activate potassium channel and hyperpolarizes membrane, decreasing SA node depolarization

Answer 44

adenosine