Tumors and Paraneoplastic Syndromes Flashcards by Marco Cicero

The 61-year-old businessman underwent surgery last year for carcinoma of the lung.
He has been suffering from headaches for about 3 weeks, which intensify with
coughing, flatulence and bending over. Analgesics do not help. He has discrete leftsided haemiparesis. It is probably:
a. brain metastases
b. carcinoma mening
c. sinusitis
d. meningitis (stiff neck, vomiting)

a. brain metastases

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The incidence of brain tumours (primary and metastases) is approximately:
a. 1/100.000
b. 10/100.000
c. 30/100.000
d. 100/100.000

c. 30/100.000

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The most common manifestation of low-grade pleomorphic xanthoastrocytoma is:
a. epilepsy
b. hemiparesis
c. cerebellar ataxia
d. hemianopsia

a. epilepsy

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The most common localisation of pilocytic astrocytoma in children is:
a. Brainstem
b. Little Brains
c. optic nerve
d. thalamus

b. Little Brains

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Which drug should be prescribed for a patient with a malignant oedematous tumour?
a. mannitol
b. sumatriptan
c. dexamethasone
d. oxygen mask

c. dexamethasone

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Where are tumours most commonly found in children?
a. infratentorial
b. supratentorial
c. on the meninges
d. in the spinal cord

a. infratentorial

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Where are brain metastases most commonly found?
a. on the surface of the crust
b. at the boundary between white and grey matter
c. on the meninges
d. in the liquor rooms

b. at the boundary between white and grey matter

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The edema around a tumour growing in the brain is?
a. vasogenic
b. cytotoxic

a. vasogenic

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Calcifications are characteristic of:
a. pilocytic astrocytoma
b. glioblastoma
c. to the seamstress
d. oligodendroglioma

d. oligodendroglioma

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Which is the most common glioma?
a. pilocytic astrocytoma
b. meningeom
c. oligodendroglioma
d. glioblastoma
e. ependymom

d. glioblastoma

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Which tumour is malignant?
a. nevrinom
b. neurofibrom
c. ependymom
d. meningeom

c. ependymom

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Where will ependymoma occur in an adult?
a. conus medullaris and filum terminale
b. Little Brains
c. cerebral hemispheres
d. thoracic spinal cord

a. conus medullaris and filum terminale

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Which tumour does not metastasise to the brain?
a. carcinoma of the lung
b. prostate cancer
c. breast carcinoma
d. malignant melanoma

b. prostate cancer

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Which medicine will not be used to treat prolactinoma:
a. ropinirole
b. Pramipexola
c. propranolol
d. bromocriptine

c. propranolol

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Spinal meningiomas are most commonly seen in:
a. younger women
b. older women
c. younger men
d. older men

b. older women

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Neurinoma will most commonly affect:
a. CN VI
b. CN VII
c. CN VIII
d. CN IX

c. CN VIII

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Pituitary adenoma is most commonly secreted by:
a. prolactin
b. ACTH
c. TSH
d. FSH/LH
e. GH

a. prolactin

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How does a tumour in the left brainstem appear?
a. affected sensation of temperature and pain on the ipsilateral side
of the face and contralateral side of the body
b. affected sensation of temperature and pain on the contralateral side of the
face and contralateral side of the body
c. ipsilateral impaired sense of touch in the ring around the corner of the mouth
d. contralateral affected sense of touch in the ring around the corner of the mouth

a. affected sensation of temperature and pain on the ipsilateral side
of the face and contralateral side of the body

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Which tumour is most characteristic of neurofibromatosis type 2?
a. gangliogliom
b. glioblastoma
c. bilateral VIIIth cranial nerve schwannoma
d. neuroblastoma
e. pilocytic astrocytoma

c. bilateral VIIIth cranial nerve schwannoma

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What is not caused by a tumour growing in the parietal nondominant hemisphere?
a. finger agnosias
b. anosognosia
c. geographical agnosia
d. apraxia of dress

a. finger agnosias

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Which tumour most commonly occludes nerves in the sphenoid sinus?
a. meningeom
b. pituitary

a. meningeom

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A 76-year-old man’s cerebellum tumour is most likely:
a. metastasis
b. medulloblastoma
c. ependymom
d. meningeom

a. metastasis

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A woman has grown a tumour that is causing her hearing problems. It is most likely to have
arisen from:
a. astrocita
b. Schwann cells
c. oligodendrocyte
d. ependymal cells

b. Schwann cells

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A patient with a brain tumour has daily complex partial seizures. The oncologist
will then treat him with vincristine. Which antiepileptic is best:
a. carbamazepine
b. oxcarbazepine
c. primidone
d. valproate
e. levetiracetam

e. levetiracetam

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What is not a microscopic feature of glioblastoma: a. necrosis b. Guest c. glomeruloid vascular structures d. multinucleated giant cell tumours e. Rosenthal fibres

e. Rosenthal fibres

It has the most favourable forecast: a. medulloblastoma b. pilocytic astrocytoma c. anaplastic astrocytoma d. glioblastoma

b. pilocytic astrocytoma

It has the least favourable prognosis: a. diffuse astrocytoma b. pleomorphic xanthoastrocytoma c. meningeom d. to the seamstress

b. pleomorphic xanthoastrocytoma

Bitemporal quadrantopsy of the upper quadrants causes: a. pituitary adenoma b. craniofaringeom c. PNET d. pinealoblastoma e. medulloblastoma

a. pituitary adenoma

What is not a risk factor for cerebellar neoplasia? a. head irradiation b. heavy metals c. neurofibromatosis d. HIV infection e. tuberous sclerosis

b. heavy metals

When will a surgeon not go in to operate on a tumour? a. when close to the surface of the skull b. when it is solitary c. when the patient's condition is good d. when lesions change on MRI after 3 months

d. when lesions change on MRI after 3 months

In a 35-year-old patient complaining of dizziness and tinnitus in the left ear, on examination you find an extinct corneal reflex on the left side, hypoesthesia and hypalgesia in the left trigeminal area, a wide left eye slit and a lowered left angle of the mouth. Most likely diagnosis: a. ischaemic stroke in the right brainstem b. tumour in the left pons c. tumour in the left pontocerebellar angle d. polyneuropathy left e. onset of ophthalmic herpes - acute left

c. tumour in the left pontocerebellar angle

A large tumour with hyperostosis is most likely a. glioblastoma b. meningeom c. to the seamstress d. oligodendroglioma

b. meningeom

Which tumour is treated with radiotherapy and temozolomide? a. glioblastoma b. oligodendroglioma c. priman lymphoma OŽ d. meningeom

a. glioblastoma

Which tumour would you expect to find in the cerebellum of a 35-year-old man? a. pilocytic astrocytoma b. haemangioblastoma c. medulloblastoma d. ependymom

b. haemangioblastoma

The most common brainstem tumour? a. glioma

a. glioma

False claim for tumours: a. medulloblastoma does not take root.

a. medulloblastoma does not take root.

Best treatment prognosis for oligodendroglioma? a. with 1p/19q codelation b. with the absence of the 1p/19q deletion

a. with 1p/19q codelation

A gentleman had surgery for lung carcinoma 6 months ago. For the last two months he has been experiencing proximal weakness in his legs. What is the likely diagnosis? a. progressive multifocal leukoencephalopathy b. dermatomyositis c. multiple sclerosis d. myasthenia gravis syndrome e. myasthenia gravis

d. myasthenia gravis syndrome

Description and picture, cystic tumour in the cerebellum of a child. It is probably: a. metastasis b. pilocytic astrocytoma c. oligodendroglioma d. medulloblastoma

b. pilocytic astrocytoma

2. A 29-year-old right-wing administrator has been experiencing vision problems for the past 3 weeks. She has limited upward vision, poor pupillary reactions, convergence nystagmus at rest. It is: a. Weber syndrome b. Benedict's syndrome c. Parinaud syndrome d. Wallenberg syndrome MRI of the head in the previous patient shows an expansive process in: e. ponsu f. meduli oblongati g. of the mesencephalon h. epiphyses

c. Parinaud syndrome h. epiphyses

How to reduce a tumour that is too big for surgery: a. methotrexate b. PCV scheme c. PCV scheme with other medicines

b. PCV scheme

When will a surgeon always opt for a complete resection of the tumour? a. A 12-year-old boy with a tumour in his brain stem b. 90 years old... c. 50-year-old man with a 5x6 cm frontal tumour d. 40-year-old woman after surgery and radiation treatment for glioblastoma e. 60-year-old woman with diffuse capsular tumour internal

c. 50-year-old man with a 5x6 cm frontal tumour

For brain tumours, the most common treatments for epilepsy are: a. ethosuximide and levetiracetam b. carbamazepine and levetiracetam c. lamotrigine and gabapentin d. topiramate and valproate

b. carbamazepine and levetiracetam

The edema around a tumour growing in the brain is? a. vasogenic b. cytotoxic

a. vasogenic

What is the case with glioblastoma? a. may look like an abscess on CT scan b. stains well with contrast on CT c. stains on MRI after contrast is added d. no staining on MRI after contrast addition e. MR spectroscopy is a useless method

c. stains on MRI after contrast is added

Which tumour most commonly invades the brain? a. Hodgkin's lymphoma b. lung carcinoma c. Seminars d. adenocarcinoma of the colon

b. lung carcinoma

Kennedy-Foster syndrome, what do we find? a. ipsilateral optic atrophy and anosmia, contralateral papilloedema b. ipsilateral optic atrophy, contralateral anosmia and papilloedema c. ipsilateral papilloedema, contralateral optic atrophy and anosmia d. ipsilateral anosmia, contralateral optic atrophy and papilloedema

a. ipsilateral optic atrophy and anosmia, contralateral papilloedema

A patient with metastasis of a lung tumour who is to be irradiated and has epilepsy, which antiepileptic drug would you treat him with? a. lamotrigine b. carbamazepine c. valproate d. diazepam e. with any of the above

b. carbamazepine

What is an arachnoid cyst? a. has the same signal as the liquid on all sequences b. In contrast-enhanced MRI, there is intense staining around the margins

a. has the same signal as the liquid on all sequences

Symptomatic treatment of CNS tumours includes: a. antiepileptics, amtiemetics, analgesics, laxatives b. medical cannabis

a. antiepileptics, amtiemetics, analgesics, laxatives

3. What is the average expected survival in oligodendroglioma with 1p/19q deletion? a. a few months b. 1 year c. 5 years d. 10 years

d. 10 years

A 41-year-old man admitted for 2 weeks of amnestic syndrome and complex partial seizures. Antibodies to Ma-1 protein were found. What are the problems associated with? a. Seminoma of the testis

a. Seminoma of the testis

What is the immunophenotype of adenocarcinoma of the lung? a. CK7+, CK20-, TTF1+, Napsn A+

a. CK7+, CK20-, TTF1+, Napsn A+

A 70-year-old man. The patient has a CSF pressure of 220 mmH2 O, a protein concentration of 1,5 g/L, a cell count of 150 mm3 , a glucose count of 0,9 mmol/L (blood 5,0 mmol/L), and negative oligoclonal bands. What is wrong with him? a. Carcinomatosis of the meninges

a. Carcinomatosis of the meninges | The reduction of glucose is due to cancer cells consumption,

The neurosurgeon will opt for a biopsy of the lesion rather than a radical resection if the results suggest: a. Primary CNS lymphoma

a. Primary CNS lymphoma

Not applicable to glioblastoma: a. Incidence is highest between 30 and 40 years of age b. It is the most common brain tumour c. Survival after chemotherapy and radiation is 1 year d. Originates in the basal ganglia e. Sometimes it overgrows the corpus callosum

a. Incidence is highest between 30 and 40 years of age d. Originates in the basal ganglia

Cerebellar defects in antibodies according to the clinical picture. a. anti-Yo b. anti-Hu c. anti-MAG d. anti-Ri

a. anti-Yo

A CNS tumour expresses the following markers: CK7+, CK20-, TTF-. What is the origin of the metastasis? a. carcinoma of the lung b. breast carcinoma c. colon carcinoma d. malignant melanoma e. prostate cancer

b. breast carcinoma

What of the following would you not expect to find in a little brain? a. abscess b. metastases c. haemangioblastoma d. medulloblastoma e. glioblastoma

e. glioblastoma

What are peripheral nerve tumours? a. to the seamstress b. neurofibrom c. fibrom d. MPNST e. ependymom

b. neurofibrom d. MPNST

Not applicable to paraneoplastic syndromes: a. respond well to corticosteroids b. occur in limited cancers c. it is best to treat the underlying disease d. subacute development of symptoms e. severe disability

a. respond well to corticosteroids

The radiotherapist has decided to give postoperative radiotherapy to the astrocytoma. What dose will he use? a. 5-10 Gy b. 20-30 Gy c. 50-60 Gy d. 90-100 Gy e. 120-130 Gy

c. 50-60 Gy

Which tumour is not WHO grade I? a. pilocytic astrocytoma b. disembryoplastic neuroepithelial tumour c. to the seamstress d. meningeom e. oligodendroglioma

e. oligodendroglioma

An elderly patient has double images, hearing loss in the left ear, headache. Paresis of the right abducens is also noted. What is it? a. behind the seam of the pontocerebellar angle b. for carcinosis of the meninges c. for brainstem glioma d. for pituitary adenoma e. for meningioma of the posterior cranial fossa

b. for carcinosis of the meninges | Dissemination of the tumor

Which is not a paraneoplastic antibody? a. Lg1 b. anti-Hu c. anti-Ri d. anti-Yo e. anti-ma1

a. Lg1

A 38-year-old gentleman with progressive dysarthria, gait faltering and intention tremor. He fails the finger-to-nose test. Most likely: a. glioblastoma b. haemangioblastoma c. medulloblastoma d. lymphoma e. oligodendroglioma

b. haemangioblastoma

A patient has a parasagittal meningioma - which symptom occurs acutely? a. epilepsy b. paraplegia due to rapid growth c. symptoms of elevated ICT

a. epilepsy

Tumors and Paraneoplastic Syndromes Flashcards

(67 cards)