Tumours of the nervous system

Question 1

What are the most common types of nerve tumours?

Answer 1

Gliomas and meningomas

Question 2

Who is most likely to get cerebellum and PNET tumour?

*PNET = medulloblastoma

Answer 2

Children

Children get cerbenellum and PNET (primitive neuroectodermal tumour)

Adults get cerebrum, glioma and meningioma tumours.

Question 3

Who is most likely to get a tumour of the cerebrum. glioma and meningioma?

Answer 3

Adults

Adults get cerebrum, glioma and meningioma tumours.

Children get cerbenellum and PNET (primitive neuroectodermal tumour)

Question 4

Which sex is more likely to get gliomas / meningiomas?>

Answer 4

Males = gliomas
Females = meningioma

Question 5

What is the role of choroid plexus cells?

Answer 5

to produce CSF

Question 6

What is the grading level given to a benign tumour?

Answer 6

I = BENIGN

II = LOW GRADE (some progression)

III = HIGH Grade (rapid progression)

IV = aggressive

Question 7

What is the histological criteria for malignancy in brain tumour?

Answer 7

1) Cellular density and atypia
2) Mitotic activity
3) necrosis
4) Vascular proliferation

Question 8

Astrocytic tumours, oligodendroglioma and ependymoma are all classified as ……

Answer 8

Glioma tumours

Question 9

The microscopical features of astrocytic tumours are :

1) fine fibrillary and microcystic background.
2) Increased cellular density
3) Pleomorphism (variation in size/shape)

What are the differences between Diffuse Astrocytoma II and Anaplastic astrocytoma III?

Answer 9

Diffuse Astrocytoma II =
- Infiltrative, microcystic, fibrillary.

• Low cellular density
• Mild atypia
• NO MITOTIC ACTIVITY

Anaplastic astrocytoma III =

• Moderate cellular density
• Moderate pleomorphism
• MITOSES

Question 10

What are the histological features of Glioblastoma IV?

Answer 10

• High cellular density and mitoses
• necrosis
• vascular proliferation

Question 11

Who is affected by pilocytic astrocytoma I

Answer 11

children

Question 12

What type of neural tumour has round uniform nuclei with clear cytoplasm (fried egg like) and arborising capillaries (chicken wire) and calcifications?

Answer 12

Oligodendroglioma (II / III)

Question 13

Whorls and psammoma bodies are characteristic of?

Answer 13

Meningioma

• Meningiomas affect females.
• it is a well defined extra axial tumour.
• has whorls and psammoma bodies

Question 14

PNET (medulloblastoma) IV has:

• very high cellular density
• anaplastic hyperchromatic cells
• frequent mitoses and apoptosis
• rosette formation

Who is most affected by PNET IV?

Answer 14

Children