Tutorial multi choice questions

Question 1

what does the mononuclear phagocyte include and not include?

Answer 1

Include: monocytes, kupffer cells, kidney mesangial cells and lymph node medullary macrophages
NOT: endothelial cells

Question 2

what does the membrane attach complex consist of?

Answer 2

C5b,6,7,8,9

Question 3

what does C3b do?

Answer 3

opsonises bacteria

Question 4

what compliment component is strongly chemotactic for neutrophils?

Answer 4

C5a

Question 5

what initial complement component is activated by complement-fixing antibodies?

Answer 5

C1q

Question 6

what complement component does the classical and alternative pathways meet?

Answer 6

C3

Question 7

when does clonal selection occur?

Answer 7

when antigen is encountered by T cells

Question 8

what does plasma cells secrete?

Answer 8

antibody of a single speciality related to that on the surface of the parent B cell

Question 9

what did Edward Jenner use to vaccinate against smallpox?

Answer 9

cowpox

Question 10

what do T cell surface receptors for antigen partly recognise?

Answer 10

MHC

Question 11

what does an immune response against grass pollen involve?

Answer 11

hypersensitive reaction

Question 12

why are secondary antibody response better?

Answer 12

stronger and faster

Question 13

what cell type produces antibodies?

Answer 13

plasma cells

Question 14

what provides protection against micro-organisms inside cells?

Answer 14

T cells

Question 15

what is the basic immunoglobulin unit composed of?

Answer 15

2 identical heavy and 2 identical light chains

Question 16

what does a Fab fragment do?

Answer 16

binds antigen

Question 17

what are the complementary determining regions concerned in?

Answer 17

antigen recognition

Question 18

what gene cluster does not contribute to antigen binding?

Answer 18

CL

Question 19

what is not true of IgG?

Answer 19

appears early in the primary immune response

Question 20

what is IgA in seromucous secretions?

Answer 20

dimeric

Question 21

what does IgE bind strongly to?

Answer 21

mast cells

Question 22

what is the Fab region of an immunoglobulin responsible for?

Answer 22

binding to antigen

Question 23

what is the main immunoglobulin in seromucus secretions defending the external body surfaces?

Answer 23

IgA

Question 24

what is the first immunoglobulin heavy chain class expressed on the surface of B cells?

Answer 24

IgM

Question 25

what is expression of MHC genes?

Answer 25

codominant

Question 26

what is a T cell receptor for antigen?

Answer 26

heterodimer

Question 27

what does each chain of the T cell receptor consist of?

Answer 27

two immunoglobulin-like domains

Question 28

what are MHC class II molecules found on?

Answer 28

B cells- dendritic cells and macrophages

Question 29

what is an antigen moiety on an antigen-presenting cell recognised by the T-cell receptor?

Answer 29

processed (peptide) antigen plus MHC

Question 30

what is an epitope?

Answer 30

the area on an antigen which contacts antibody

Question 31

what does binding of antigen to antibody depend on?

Answer 31

spatial complementarity

Question 32

what do T cell receptors recognise?

Answer 32

linear antigen peptide in the MHC groove

Question 33

Name a primary lymphoid organ.

Answer 33

thymus

Question 34

what is expression of a CD8 a characteristic of?

Answer 34

cytotoxic T lymphocytes

Question 35

what immunoglobulin class crosses the placenta to provide a high level of passive immunity at birth?

Answer 35

IgG

Question 36

what are extracellular bacteria optimally killed by?

Answer 36

macrophages plus antibody plus complement

Question 37

what are the mucosal surfaces initially protected by?

Answer 37

secretory IgA

Question 38

what is the protection against worm infections infestations particularly associated with an increase in?

Answer 38

IgE

Question 39

what disease has been completely eradicated world-wide?

Answer 39

smallpox

Question 40

what do defects in neutrophil NADPH oxidase produce?

Answer 40

chronic granulomatous disease

Question 41

what does HIV bind to?

Answer 41

CD4

Question 42

what can a type I hypersensitivity be blocked by?

Answer 42

sodium cromoglycate

Question 43

which type pf hypersensitivity cannot be transferred with serum antibody?

Answer 43

Type IV

Question 44

what does rhesus haemolytic disease of the newborn involve?

Answer 44

antibody to cell surfaces

Question 45

what is type IV hypersensitivity often referred to as?

Answer 45

delayed

Question 46

Name a non-organ-specific (systemic) autoimmune disease.

Answer 46

systemic lupus erythematosus

Question 47

what can pernicious anaemia be treated with?

Answer 47

Vitamin B12

Question 48

what is a therapeutic approach in rheumatoid arthritis?

Answer 48

inhibit TNF alpha activity