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Flashcards in Tutorial multi choice questions Deck (48)
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1

what does the mononuclear phagocyte include and not include?

Include: monocytes, kupffer cells, kidney mesangial cells and lymph node medullary macrophages
NOT: endothelial cells

2

what does the membrane attach complex consist of?

C5b,6,7,8,9

3

what does C3b do?

opsonises bacteria

4

what compliment component is strongly chemotactic for neutrophils?

C5a

5

what initial complement component is activated by complement-fixing antibodies?

C1q

6

what complement component does the classical and alternative pathways meet?

C3

7

when does clonal selection occur?

when antigen is encountered by T cells

8

what does plasma cells secrete?

antibody of a single speciality related to that on the surface of the parent B cell

9

what did Edward Jenner use to vaccinate against smallpox?

cowpox

10

what do T cell surface receptors for antigen partly recognise?

MHC

11

what does an immune response against grass pollen involve?

hypersensitive reaction

12

why are secondary antibody response better?

stronger and faster

13

what cell type produces antibodies?

plasma cells

14

what provides protection against micro-organisms inside cells?

T cells

15

what is the basic immunoglobulin unit composed of?

2 identical heavy and 2 identical light chains

16

what does a Fab fragment do?

binds antigen

17

what are the complementary determining regions concerned in?

antigen recognition

18

what gene cluster does not contribute to antigen binding?

CL

19

what is not true of IgG?

appears early in the primary immune response

20

what is IgA in seromucous secretions?

dimeric

21

what does IgE bind strongly to?

mast cells

22

what is the Fab region of an immunoglobulin responsible for?

binding to antigen

23

what is the main immunoglobulin in seromucus secretions defending the external body surfaces?

IgA

24

what is the first immunoglobulin heavy chain class expressed on the surface of B cells?

IgM

25

what is expression of MHC genes?

codominant

26

what is a T cell receptor for antigen?

heterodimer

27

what does each chain of the T cell receptor consist of?

two immunoglobulin-like domains

28

what are MHC class II molecules found on?

B cells- dendritic cells and macrophages

29

what is an antigen moiety on an antigen-presenting cell recognised by the T-cell receptor?

processed (peptide) antigen plus MHC

30

what is an epitope?

the area on an antigen which contacts antibody