U1 day 1 Flashcards
(24 cards)
endocrine system
Hormone system that communicates between cells in body
Hormone
chemical secreted in trace amounts by one or more cells
Tropic hormone
hormone that targets another endocrine tissue
endocrine
through blood
exocrine
through duct
gland
organ that can secrete chemicals to be used in the body, not all glands secrete hormones
Endocrine mode of action
uses circulatory system to transport the ligand to target cells
paracrine
ligand acts on nearby cells
autocrine
Ligand acts on the secreting cell
protein and peptide hormone synthesis
small or large, linear, ring, or dimers. uses transcription and translation, alternative splicing, and post translational gene regulation
peptide hormone growth path
preprohormone(ER), prohormone(vesicle), hormone
Steroid hormone synthesis
stimulated by tropic peptide hormones, mainly produced in adrenal cortex and gonads, cholesterol is the precursor for all steroid hormones.
Glucocorticoids
glucose + cortex + steroid, role in glucose metabolism, regulates immune response, cortisol, corticosterone, cortisone
Mineralocorticoids
regulated electrolytes and fluid balance, aldosterone
Modified fatty acid hormones
derived from 20 carbons, includes prostaglandins (PG), TX, LT, and LX. Has autocrine and paracrine actions.
Fatty acid hormone synthesis
rate limiting step is the release of Arachidonic acid, Cox produces cyclic endoperoxide intermediates, inflammatory steroids inhibit phospholipase A2
Humoral hormone release
response to changes in composition of the extracellular fluid (levels of ions or nutrient in the blood)
Hormonal hormone relase
stimulated by other hormones (presence or absence)
Neural hormone relase
Stimulated by nerves
principle of homeostasis
most hormones are secreted or inhibited around the need to stay at homeostasis, they use feedback loops to control this
neurotransmitters
Amino acid derivatives, glutamate (+) and GABA (-) are used for fast acting inhibitory transmitters
Monoamines (neurotransmitter)
Dopamine, norepinephrine, epinephrine, serotonin
regulated secretion
hormone is stored after secretion, and used when needed
Constitutive secretion
cell doesn’t store hormone, it is released as soon as it is made