UA WI18-Chapter 10 Blood Disorders Part 1 Flashcards
(131 cards)
A decrease in the number of RBC or less than normal quantity of Hb in blood.
Anemia
Increased amount of RBC in blood.
Polycythemia
What are the three main classes of anemia?
Excessive blood loss
Deficient RBC production
Excessive blood cell destruction
Sx. Common to all anemia.
Weakness, fatigue, pallor, malaise, dyspnea, tachycardia, murmur(systolic), low blood pressure, dizziness, headaches coldness, weak pulse etc.
Acute blood loss is caused _______ and results in _______.
Trauma, surgery, GI tract lesions, Gynecolgic disturbance
Results in hypovolemia
Term for decreased blood volume
Hypovolemia
In an acute blood loss case report, what would be found?
Decreased platelet
Increased neutrophils (shift left)
Changes in RBC morphology: normal initially—> hypochromic once volume restored
Chronic blood loss is caused by______.
When do symptoms appears?
Cancer, menstruation, fibroids in older women and angiodysplasia.
When iron store is depleted
In a chronic bleeding case report, what is reported?
Elevated platelets
Leukopenia
RBC morphology: Normocytic or microcytic/ hypochromic
What are the causes of deficient RBC production?
Iron-deficiency anemia
Vit. Deficiency anemia
Bone marrow or stem cell problem
Health disorders: i.e renal insufficiency
Iron deficient anemia is described as?
Low RBC amount or low Hb
Iron deficiency anemia causes?
Insufficient intake
Duodenal malabsorption
Iron loss from bleeding
Increased need- e.g growth spurt
Iron deficiency clinical presentation?
PICA Koilonychia-spoon shaped brittle nails Sleepiness Angular cheilitis Mouth ulcers Hair loss Missed menstrutation Depression
Iron deficiency hematology report?
HYPOCHOMIC/MICROCYTIC
Anisocytosis/poikilocytosis
Leukocytes unaffected
Megaloblastic anemia is described as?
A condition is which the bone marrow produces unusually large, structurally abnormal immature RBC
Causes of megaloblastic anemia
Vit. B12 , Vit. B9 or both
Both needed for maturation of blood cell and normal nerve cell function
Abnormal DNA synthesis and Delayed cell division, with normal Hb & RNA synthesis in megaloblastic anemia is a result of ?
B9 and B12 deficiency
Etiological factors of B12 deficiency
Deficient intake
Lack of IF
Malabsorption syndrome-ileum
Worm infection
Increased used (pregnancy)
Etiological factors of B9 deficiency
Deficient intake
Alcoholism
Malabsorption- duodenum, jejunum
Increased use (pregnancy)
Clinical manifestation of megaloblastic anemia a/w B12 deficiency?
Fatigue, dyspnea, muscle weakness, glossitis, GI problems
Megaloblastic anemia a/w with B12 deficiency will result in _______ which is characterized by_______.
Result in: irreversible nervous system pathology collectively know as Subacute combined degeneration of spinal.
Characterized by: Demyelination of posterior and lateral columns and psychological problems.
What is the AKA term for subacute combined degeneration of spinal cord?
Lichtheim disease
Lichtheim disease is clinically manifested by:
Numbness/tingling in fingers extremities
Loss of balance, vibration and ataxia
Paraplegia
Depression, dementia
Tx for megaloblastic anemia a/w B12 deficiency
B12 by supplement
Injection of b12