Ulcerative Colitis Flashcards
(15 cards)
What drugs should be avoided in a flare-up of ulcerative colitis due to the increased risk of toxic megacolon?
Codiene and Loperamide
Complications of UC?
Secondary osteoporosis
Increased VTE risk
Colorectal cancer
Toxic megacolon
Symptoms of UC?
Muccorrhoea
Diarrhoea
Weigt loss
Abdo pain
Tenesmus
Rectum bleeding
Polyps
Urgency
How is the severity of UC measured?
TrueLove & Witts severity index
1st line therapy for acute severe UC flare-up?
IV corticosteroids or IV ciclosporin if CI
1st line therapy for acute mild-moderate proctitis or proctosigmoiditis?
topical aminosalicylate
2nd line therapy for acute mild-moderate proctitis or proctosigmoiditis/ left-sided UC?
In no remission to 1st line therapy after 4 weeks- Oral aminosalicylate (High-dose if proctosigmoiditis or left-sided UC)
3rd line therapy for acute mild-moderate proctitis or proctosigmoiditis/ left-sided UC?
Addition of topical/ oral corticosteroid for 4-8 weeks if no remission to second line therapy
Treatment of moderate to severe flare-up of UC?
Biologics or Janus Kinase inhibitors- can be continued into maintenance phase if induces remission
Name the biologics used in UC?
Adalimumab, golimumab, infliximab, and vedolizumab
What is the most effective administration of aminosalicylates?
Once daily dosing more effective than multiple daily dosing but this can increase risk of side effects
Use of methotrexate in UC?
No evidence for this
When should mercaptourine or azathiopurine be used in UC?
for maintenance if:
Remission is not maintained by aminosalicylates.
2+ exacerbations in 12 months that required treatment of oral corticosteroids.
Once acute severe exacerbation experienced.
2nd line therapy for acute severe UC flare-up?
IV corticosteroid + IV ciclosporin
3rd line therapy for acute severe UC flare-up?
Infliximab
