Unclassified Toxins-Toxic Principles Flashcards Preview

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Flashcards in Unclassified Toxins-Toxic Principles Deck (11):
1

Alsike clover and Red clover

MoA-hepatotoxicity + secondary photosensitization in horses only, hepatic encephalopathy at large amnt

CSs-lacrimation, photophobia, erythema, pruritis, edema, necrosis, sloughing of skin

Plants-alsike clover, red clover

2

Avocado

MoA and CSs- cardiotoxicity in goats, horses, rabbits, and caged birds. Non-infectious mastitis and agalactia in cattle, horses, goats, and rabbits

Plants-avocado

3

Black Walnut

MoA and CSs- Ingestion of fresh shavings made from heartwood (used as bedding) causes laminitis

Plants-Black Walnut

4

Forage-induced photosensitization

MoA- primary photosensitization, also secondary d/t liver damage

CSs-lacrimation, photophobia, pruritis, edema, necrosis, and sloughing of the skin

Plants-Moldy alfalfa, red clover, moldy wheat

5

Grapes and Raisins

MoA-an unknown toxin xauses renal failure ONLY IN DOGS

CSs- Gi signs including vomiting followed by signs of ARF

Plants-grapevine

6

Lily

MoA-an unknown toxin causes renal failure in CATS ONLY, Gi irritation in dogs and cats

CSs-GI signs including salivation, vomiting, depression and complete anorexia, PU followed by anuria and death from ARF

Plants-Easter lily, tiger lily, Japanese show lily, rubrum lily, lily hybrids, day lily

7

Pigweed

MoA-
Acute-nitrate-->methemogobinemia
Chronic-abortion :(
Soluble oxalate-hypocalcemia and kidney damage
Unknown-renal tubular damage-->ruminants, pigs horses

CSs- depression weakness, incoordination, renal failure

Plants-pigweed

8

Red Maple

MoA-Unknown toxin in dried leaves-->hemolytic anemia, hemoglobinemia, heinz bodies

CSs-anorexia, depression, anemia, icterus, brown MM, hemoglobinuria, dyspnea, cyanosis, death

Plants-Red Maple

9

Senna

MoA-Unknown mechanism-->skeletal muscle myopathy and cardiomyopathy. Antroquinone-->cathartic

CSs-diarrhea, muscle weakness, recumbancy, good appetite, myogobinuria, coffee colored urine, tachycardia, death

Plants-coffee senna, sicklepod

10

Yellow starthistle and Russian knapweed

MoA-Toxins interact with dopamine transporters resulting in death of dopaminergic neurons in the brain

CSs-equine nigropalladial encephalomalacia

Plants-yellow starthistle and russian knapweed

11

Macadamia Nuts

MoA-Unknown and Toxin is unknown

CSs-Dog-weakness in hindlimbs, depression, ataxia, tremors, hyperthermia, lameness, recumbency, vomiting, colic diarrhea, pale MM. FULL RECOVERY IN 2 DAYS