UNIT 1

Question 1

130 BC: recorded that individuals who had previously contracted
plague recovered. He recognized the “immune” status of those
individuals.

Answer 1

THUCYDIDES

Question 2

1000: _____ practiced a form of immunization by inhaling dried powders
derived from smallpox lesions
● Concept of Variolation

Answer 2

Chinese

Question 3

15th century: _______ powdered smallpox crust were inserted with a pin on the skin

Answer 3

In England,

Question 4

1717: Observed the inoculation practice of Chinese against
smallpox and brought it to England “The smallpox, so fatal, and so general against us, is
here entirely harmless,

Answer 4

lady mary worthy montague

Question 5

1798: Demonstrated cross
immunity; Smallpox
vaccination

Answer 5

edward jenner

Question 6

1862: phagocytosis

Answer 6

haeckel

Question 7

Live attenuated, chicken
cholera and anthrax vaccine

Answer 7

louis pasteur

Question 8

1862: (Father of
Immunology and
Modern
Microbiology)

Answer 8

Louis pasteur

Question 9

First report of live “attenuatedˮ vaccine for rabies
Proved the Germ Theory of Disease
Invented the process of Pasteurization

Answer 9

louis pasteur

Question 10

1883-1905: Cellular theory of immunity
through phagocytosis

Answer 10

elie metchnikoff

Question 11

1890: Humoral theory of immunity
proposed; serum

Answer 11

emil von behring, kitasato

Question 12

1891: Demonstration of cutaneous
(delayed-type)
hypersensitivity

Answer 12

robert koch

Question 13

Accidentally demonstrated
delayed hypersensitivity
reaction

Answer 13

tuberculin test

Question 14

false positive
for TB infection because of
presence of antigen due to
previous infection

Answer 14

tuberculin test

Question 15

better than
tuberculin test
○ Analyzed in CURRENT ACUTE
PHASE of TB infection.

Answer 15

IGRA TEST : interferon gamma release

Question 16

1900: antibody formation theory

Answer 16

ehrlich

Question 17

1902: Immediate-hypersensitivity
Anaphylaxis (allergy)
● Also known as Type I
hypersensitivity
● Immediate response and due
to IgE (antibody that triggers
allergic reaction)

Answer 17

portier, richet

Question 18

1903: Arthus reaction of
intermediate hypersensitivity
● Type III hypersensitivity due
to immune reaction

Answer 18

nicolas maurice arthus

Question 19

1938: Hypothesis of antigen- antibody
binding

Answer 19

marrack

Question 20

1944: Hypothesis of allograft
rejection
● Described immunologic
processes in transplantation

Answer 20

peter medawar

Question 21

1949: Development of polio vaccine

Answer 21

JTF

John enders
Thomas weller
Frederick robbins

Question 22

1950s: polio vaccine din but This is said to be better because you have an option to choose
how to administer the vaccine

Answer 22

SALK - IPV
SABIN - OPV

Question 23

1951: Vaccine against yellow fever

Answer 23

REED

Question 24

1953: Coined and was behind the principle of
immunoelectrophoresis

Answer 24

GRABAR WILLIAMS

Question 25

1953: Graft-versus- Host reaction

Answer 25

dick w. van bekkum

Question 26

1957: Clonal selection theory

Answer 26

BURNET

Question 27

1957: Interferon (viral interference)

Answer 27

alick isaacs and jean lindemann

Question 28

1958- 1962: HUMAN LEUKOCYTE ANTIGEN

Answer 28

JEAN DAUSSET

Question 29

1964-1968: T cell and B cell cooperation in immune cooperation

Answer 29

henry claman

Question 30

1972: Identification of antibody molecule The Y-structure of antibody

Answer 30

EDELMAN AND PORTER

Question 31

1975: First monoclonal antibodies

Answer 31

kohler and milstein

Question 32

1977: RIA

Answer 32

rosalyn yalow

Question 33

1978-1987: Awarded Nobel Prize for genetic principle of antibody diversity

Answer 33

susumo tonegawa

Question 34

Awarded Nobel Prize for their contribution MHC gene

Answer 34

SCB George snell, jean dausset, baruj benacerraf

Question 35

1985-1987: Identification of genes for T cell receptor

Answer 35

james p. allison

Question 36

1986: Monoclonal hepatitis B vaccine

Answer 36

pablo DT valenzuela

Question 37

1986: Th1 versus Th2 model of T helper cell function

Answer 37

mossman

Question 38

1996-1998: identification toll like receptor

Answer 38

jules hoffman and bruce beutler

Question 39

1997: Discussed their approaches to develop “better vaccines. ˮ They were intrigued by the ssmRNA use in coding the blueprint DNA to make proteins that can function in the body

Answer 39

drew weissman katalin karikó

Question 40

2001: FOXP3, the geen directing regulatory t-cell development

Answer 40

ramsdell and colleagues

Question 41

2005: Development of human papilloma virus HPV vaccine

Answer 41

IAN FRANZER

Question 42

2008: Awarded the Nobel Prize for their discovery of HIV

Answer 42

Harald zur hausen françoise barre sinoussi luc montagnier

Question 43

Jan 2020: BioNTech proponents. ● Focused first on cancer immunotherapies until they used the model mRNA COVID10 vaccines, shown positive results in all important 3 clinical trials.

Answer 43

ugur sahir ozlem tureci