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IMMUNOSERO LEC > UNIT 2.2 > Flashcards

UNIT 2.2 Flashcards

(59 cards)

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1
Q

chemotactic factors of neutrophils

A
  1. bacterial lipoteichoic acid
  2. c’peptide (complement peptide) - C5a
  3. leukotriene b4
  4. mast cell derived chemotactic peptide
  5. neutrophil chemotactic peptide (interleukin 8)
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2
Q

monocyte triggering factors

A
  1. transforming growth factor
  2. monocyte chemotactic protein 1- MCT1
  3. RANTES
  4. Macrophage inflammatory proteins
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3
Q

Substance present on a pathogenʼs cell wall
● Also LPS
● More on detection

A

bacterial lipoteichoic acid

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4
Q

By the WBC, but specifically Basophils and Mast Cells
● Attracts leukocyte to the site of infection
● Inflammatory granules of basophil and mast cells

A

leukotriene B4

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5
Q

TNF alpha
● Released by Macrophage and Mast Cell
● Activated macrophage to induce further inflammation and phagocytosis
● With IL1
○ Pyretic or pyrogenic - causes fever

A

transforming growth factor

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6
Q

Attracting monocyte to the site of infection
● TNFB
● Interferon gamma IFNy

A

macrophage inflammatory proteins

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7
Q

Attracting monocyte to the site of infection
● TNF-B
● Interferon gamma (IFNy)

A

macrophage inflammatory proteins

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8
Q

opsonin receptors

A
  1. FcyR-IgG
  2. CR1- C3B
  3. CRP Receptors
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9
Q

multilineage production of
hematopoietic stem cells
■ Also known as multilineage cytokine
■ Released by many cells esp by the
lymphocytes
■ Increase hematopoiesis once it
triggers the bone marrow

A

IL3

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10
Q

causes the bone marrow to
produce more cells needed by immune
cell that will trigger the release of cells

A

IL3

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11
Q

promotes maturation of T
and B cells in their respective organs

A

IL7

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12
Q

immature thymocytes
● Double negative thymocyte (from bone marrow) in the
cortex through gene rearrangement becomes double
positive (to mature) through IL7

A

Cortex

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13
Q

Those with high affinity with MHC molecules
are eliminated via apoptosis while moderate
affinity can mature

A

TRUE

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14
Q

mature T cells & APC

A

Medulla

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15
Q

Starts at the cortex and mature and
stay in the medulla

A

Double Negative Thymocytes

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16
Q

goes to the Secondary Lymphoid Organ

A

Mature t -cell

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17
Q

release
cytokines that target dendritic
cell activity.

A

Thymic corpuscles

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18
Q

Promotes the action of the
APCs
● Also known as Hassallʼs
corpuscle

A

THYMIC CORPUSCLES

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19
Q

Filters the lymph of impurities
● Provides an environment where immune cells can interact
with foreign agents

A

LYMPH NODE

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20
Q

B cell area
Also known as the Germinal Centers of the
lymph node

A

CORTEX

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21
Q

resting /naive cells
■ Fresh from the Bone Marrow

A

primary follicle

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22
Q

primed B cells

A

secondary follicle

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23
Q

T cell area
○ Also known as the deep cortical region of the
Lymph Node
○ Near the Blood Vessels

A

paracortex

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24
Q

Plasma cells
○ Near the vessels so antibodies produced can be
released immediately

Study These Flashcards
A

medullary cord

25
Movement of lymphocytes from the blood to the lymphoid organs and back to the blood.
lymphocyte recirculation
26
Protects the body from foreign antigens in the blood: remove effete RBC, Immune complexes, Opsonized microbe from the circulation; initiate interaction of immune cells to blood borne antigens.
spleen
27
Also known as the graveyard of blood cells ○ Because of its capability of pitting (biting) and culling (killing)
SPLEEN
28
biting
pitting
29
killing
culling
30
House naive B cell and T cell and our APCs
spleen
31
Majority of B cells is here = antibody secretion is at PEAK
spleen
32
B cell area
marginal zone
33
T cell area
Periarteriolar Lymphoid Sheath PALS
34
Plasma cells
medullary cord
35
Houses a lot of B cell compared to lymph node ○ Antibody secretion is at peak
spleen
36
circulation and marginating pools
neutrophil
37
Blood circulation
monocyte
38
Frustrated phagocytosis
neutrophil
39
Sustained or Facilitated Phagocytosis
monocyte , macrophage
40
Enhances phagocytosis by making antigen big and recognizable ■ Immunoglobulin (antibodies) ■ Complement protein ■ Acute phase reactant ○ Causes phagocytosis
opsonin receptor
41
most potent APR ■ Affinity to the C polypeptide to the pneumococcal ■ Similar function as antibodies, they serve as opsonin ■ Capable of activation of complement proteins
CRP- C reactive proteins
42
This will further advance the inflammation ○ Final Product ○ Attaches to the cell wall of the pathogen ■ While in here, it creates pores. So if they are not eaten by pathogen, this complement proteins will lyse the proteins
complement proteins
43
Neutralizes cell surface of pathogen
antibodies
44
Present More sensitive in cytokines
monocyte + macrophages
45
important granule of neutrophil that attacks the parasites
major basic protein
46
Smallest granulocytes - Stimulate B cell to produce antibodies - Promoter of inflammation (due to granules) - Seen in Blood
basophilm
47
- Resemble the basophils (dark granules) - Origin of mast cells: mesenchymal connective tissue
mast cells
48
Professional Antigen Presenting Cells ● Most potent phagocyte
dendritic cells
49
Third Population Cells/Large Granular Lymphocytes
natural killer cells
50
No CD2 or TCR receptors but have similar functions as Tc in which is the cytotoxic reaction ○ Uses their perforin (pores) and granzymes (grandy)
Primitive T Cytotoxic Cells
51
If may katabi siyang antibody-labeled cell → NK will cause cytotoxic reaction ○ Recognizes the antibody-labeled cell like a phagocyte
ADCC
52
Minority of the population can mature in the thymus
TRUE
53
Majority of NK cells mature in bone marrow
TRUE
54
Killer Inhibitory Receptors Prevent; killing of self
KIR
55
binds to MHC Class I
CD94/NKG2A
56
INHIBITORY RECEPTORS
1. KIR 2. CD94/NKG2A
57
important CD marker that identifies NK cells along with CD56
CD16
58
activation receptors
CD16 NKG2D
59
Both receptors bind to diseased and cancer cells - cells producing stress proteins
TRUE

IMMUNOSERO LEC (4 decks)

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