Unit 3-Antidepressants Flashcards Preview

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Flashcards in Unit 3-Antidepressants Deck (61):
1

Tranylcypromine

Drug class

MAOi

2

Tranylcypromine

Mechanism

Irreversibly inhibit both MAOa and MAOb

3

Tranylcypromine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

4

Tranylcypromine

Side effects

  • Hypertensive crisis (with tyramine-rich foods);
  • serotonin syndrome (MAOI + SSRI); agitation (rare), delerium --> seizures
  • Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation

5

Phenelzine

Drug class

MAOi

6

Phenelzine

Mechanism

Irreversibly inhibit both MAOa and MAOb

7

Phenelzine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

8

Phenelzine

Side effects

  • Hypertensive crisis (with tyramine-rich foods)
  • serotonin syndrome (MAOI + SSRI); agitation (rare), delerium --> seizures
  • Anticholinergic, orthostatic hypotension, sexual dysfunction, weight gain, sedation

9

Desipramine

Drug class

Tricyclic

10

Desipramine

Mechanism

  • Block reuptake of NE or 5-HT at varying potencies and selectivity;
  • also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

11

Desipramine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

12

Desipramine

Side effects

  • Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  • Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Not very safe; rarely used anymore

13

Imipramine

Drug class

Tricyclic

14

Imipramine

Mechanism

  • Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors
  • forms active metabolite (desipramine)

15

Imipramine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

16

Imipramine

Side effects

  • Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  • Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Not very safe; rarely used anymore;

17

Amitriptyline

Drug class

Tricyclic

18

Amitriptyline

Mechanism

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

19

Amitriptyline

Uses

  • Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism;
  • prevention of tension headaches, migraines

20

Amitriptyline

Side effects

  • Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  • Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Not very safe; rarely used anymore;
  • forms active metabolite (nortriptyline)

21

Nortriptyline

Drug class

Tricyclic

22

Nortriptyline

Mechanism

Block reuptake of NE or 5-HT at varying potencies and selectivity; also variably block muscarinic, a-adrenergic, dopamine, and histamine receptors

23

Nortriptyline

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

24

Nortriptyline

Side effects

  • Sympathomimetic (cardiac arrhythmias and conduction defects, especially at OD)
  • Antimuscarinic, orthostatic hypotension, sedation (additive with alcohol), seizures
  • Not very safe; rarely used anymore

25

Fluoxetine

Drug class

SSRI

26

Fluoxetine

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

27

Fluoxetine

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

28

Fluoxetine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; pre-menstrual dystrophic disorder

29

Fluoxetine

Side effects

  • Serotonin syndrom (with MAOIs)
  • Fewer than tricyclics;
  • mostly nausea, decreased sexual function
  • Potent P450 inhibitor;
  • forms active metabolite (norfluoxetine)

30

Paroxetine

Drug class

SSRI

31

Paroxetine

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

32

Paroxetine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

33

Paroxetine

Side effects

  • Serotonin syndrome (with MAOIs)
  • Fewer than tricyclics;
  • mostly nausea, decreased sexual function
  • Potent P450 inhibitor

34

Sertraline

Drug class

SSRI

35

Sertraline

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

36

Sertraline

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

37

Sertraline

Side effects

  • Serotonin syndrome (with MAOIs)
  • Fewer than tricyclics;
  • mostly nausea, decreased sexual function

38

Escitalopram

Drug class

SSRI

39

Escitalopram

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

40

Escitalopram

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

41

Escitalopram

Side effects

  • Serotonin syndrome (with MAOIs)
  • Fewer than tricyclics;
  • mostly nausea, decreased sexual function

42

Citalopram

Drug class

SSRI

43

Citalopram

Mechanism

Inhibit reuptake of 5-HT (and NE to lesser extent)

44

Citalopram

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

45

Citalopram

Side effects

  • Serotonin syndrome (with MAOIs)
  • Fewer than tricyclics;
  • mostly nausea, decreased sexual function

46

Duloxetine

Drug class

SNRI

47

Duloxetine

Mechanism

Inhibits reuptake of 5-HT and NE

48

Duloxetine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

49

Venlafaxine

Drug class

SNRI

50

Venlafaxine

Mechanism

Inhibits reuptake of 5-HT and NE

51

Venlafaxine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

52

Buproprion

Drug class

Atypical

53

Buproprion

Mechanism

Blocks DA and NE reuptake

54

Buproprion

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism; maintain nicotine abstinence in quitting smokers

55

Buproprion

Side effects

Lowers seizure threshold

56

Mirtazapine

Drug class

atypical

57

Mirtazapine

Mechanism

5HT2a antagonists; also inhibit 5HT reuptake

58

Mirtazapine

Uses

Depression, anxiety, PTSD, chronic pain, enuresis, bulimia, alcoholism

59

Lithium

Mechanism

Unknown; lithium depletes secondary messengers IP3 and DAG, important in a-adrenergic and muscarinic-cholinergic transmission

60

Lithium

Uses

  • Anti-manic/mood-stabilizing (bipolar);
  • long-term cluster headache prevention

61

Lithium

Side effects

  • If elevated levels: neurotoxicity, cardiac toxicity, renal dysfunction
  • Drowsiness, weight gain, tremor, polydipsia, polyuria
  • Nausea and vomiting early sign of lithium OD;
  • indomethacin and Na-depleting diuretics should be avoided (increase [Li])