Unit 4: Chapter 3 Flashcards

1
Q

Amino acid structure:

A

alpha carbon with:
amino group (NH3+)
Carboxylic Acid (COO-)
Hydrogen atom
R group

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2
Q

D amino acids can occur where

A

nature and mostly bacterial cell walls

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3
Q

D Isomer of amino acids indicate

A

Amino Group (NH3+) is on right

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4
Q

D amino acids not found in

A

proteins

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5
Q

L isomer of amino acids indicate

A

Amino group (NH3+) is on left

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6
Q

At pyshiological pH 7.4, what group will be pronotated?

NH3+ or COO-

A

Amino group

pKa > pH

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7
Q

At pyshiological pH 7.4, what group will be depronotated?

NH3+ or COO-

A

Carboxylic group

pKa < pH

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8
Q

Amino acids can be sorted into four groups on basis of

A

general characteristics of their R groups

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9
Q

Nonpolar side chains of amino acids indicate:

A

Hydrophobic

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10
Q

Polar side chains of amino acids indicate:

A

uncharged, hydrophillic, positively charged, negatively charged

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11
Q

Nonpolar amino acids are typically found where in the proteins?

A

Interior of proteins

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12
Q

Polar amino acids are typically found where in the proteins?

A

Surface of proteins

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13
Q

Which side chaisnare positively charged at pH 7?

A

KRH

Lysine, Arginine, Histidine

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14
Q

What amino acid can be uncharged or positively charged at neutral pH?

A

Histidine

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15
Q

What amino acids are negatively charged at neutral pH?

A

D, E

glutamic acid and aspartic acid

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16
Q

What amino acid is least basic?

A

Histidine

Imidazole ring in side chain loses its proton at about pH 6 (very low)

17
Q

When pKa > pH, what predominates?

A

weak acid predominates
H+ on, substance is protonated

18
Q

When pKa < pH, what predominates?

A

conjugate base predominates
H+ off, substance deprotonated

19
Q

Isoelectric Point (pI)

A

pH at which a molecule has no net charge

20
Q

pI for bascic side chain

A

pI will be higher pH because the basic side chain introduces an “extra” positive charge

21
Q

pI for acidic side chain

A

pI will be at a lower pH because the acidic side chain introduces an “extra” negative charge