Unit 4, hippocampus and na, floh Flashcards Preview

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Flashcards in Unit 4, hippocampus and na, floh Deck (35):
1

what is the major cell type in the dentate gyrus?

granule cells

2

cells in the inner 1/3 of the DG are innervated by the this type of fiber

mossy cells

3

mossy fibers in the Dg connect where?

to pyramidal cells in CA3

4

what is special about the mossy fiber/CA3 connection?

sparse, but potent; 1:14

5

what connections come into the DG outer 1/3?

connections from the entorhinal cortex, perforant path

6

is the dG "in the slice?"

yes! spread is less than 400 um

7

what kind of cell is in the hillus and what nt?

glutamatergic mossy cells

8

where are mc of the hillus connecting?

to granule cells of the DG

9

are hillus cells in the slice?

no, project contra too, via associational commisural fibers

10

what fourthings innervate ca3 cells?

dg, recurrent collaterals in ca3, peprofrant path and interneurons

11

what is the connections of ca3 with ca1 called?

projection via chaffer collaerals

12

what is unique about CA3 septo-temporal spread?

very large! talks to everybody; 7mm!!

13

CA1 has compact information, simlar to area

DG

14

where do the pyramidal cells in ca1 go?

project to subicular cells

15

what is the major projection of the subiculum?

out of the hipp, to the cortex, + interneurons

16

what is the role of interneurons in the hippocampus (DG)?

layer, input specific, GABA, few, but can shunt Glut

17

what are three subcortical inputs to the hippocapus?

amygdala, septum, thalamus

18

what are efferents of the subiculum?

thalamus, amygdala, hypothalams, nA

19

what is the role of the hippocampus:

declarative memory. HM, profound anterograde amnesia, probs in declarative mem. consolidation and temporary storage of

20

two tests that would help determine cognative memory in tact in an amnesiac

stem completion and percepual id

21

two non-declaritive tasks that hm is good at:

drawing looking at a mirror, and weather prediction

22

hm cannot do these declaritive tasks

paired assc, draw from memory, story recall.

23

one problem with the slice prep

most intrhippoampal projections cover a substantial spread

24

what is the main function of mossy cells:

mediate communication between dg cells along the axis

25

do CA1 cells talk to each other?

no!

26

what are the major input stations to the hipp

ca1 and the dg

27

what is the main function of interneurons

synchronized, rhythmic activity

28

what is the major subcortical input and output region

septum

29

what is the main nueron type in the NA/

MSN, gabageric ach or gaba inter

30

in a sentence, what is the function of the na?

sensory motor integration

31

why is the core "more motor?"

because it recieves input form substantia nigra

32

why is shell more limbic?

recieves VTA

33

evidence that na are involved in motivation

cells that change their firing rate when presented with an appetitive or aversive stimuli

34

what is a typical "core' coding of rewared?

cue, lots of firing, until reward is presented, fire again.

35

how is drug addiction coded in na?

increased da, more firing