Unit 7 - Rheumatoid Arthritis

Question 1

Rheumatoid Arthrits

Answer 1

Chronic Inflammation.
Affects small joints.
Autoimmune disease.
Immune mediated inflammatory disease.

Question 2

Symptoms of RA

Answer 2

Synovial membrane. Middle of joints (Fingers). Symmetrical
Early morning, lasts more than 45 min.
Entire body

Question 3

Osteoarthritis

Answer 3

Bone ends rub together. No cartilage.

Affects people over 40

Question 4

Which is more severe RA or OA?

Answer 4

RA

Question 5

What is the cause of RA

Answer 5

Immune system attacking the body.

Question 6

Age of those affected by RA

Answer 6

20-60

Question 7

Citrullination

Answer 7

Arginine converted to citruline.

Question 8

Progression of RA

Answer 8

Post transcriptional regulation
Citrulination
ACPA and RF1 attack citrulinated proteins
Antibodies usually tag around the joints.

Question 9

RA Pathogenesis

Answer 9

Antigen presented via MHC II
Cytokines call B cells which form RF1 antibodies. This will clog up and cause pannus (hypertrophied synovium)
Fibroblasts also contribute to pannus.

Question 10

Pannus

Answer 10

Hypertrophied Synovium.

Question 11

Two antibodies fighting Citruline

Answer 11

Rheumatoid Factor

ACPA (Anti-citurlinated Protein Antibody)

Question 12

Rheumatoid Factor

Answer 12

Autoantibody. Defends against self antigens.