Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Biochem 2 > Unit Two B And C > Flashcards

Unit Two B And C Flashcards

1
Q

How can glucokinase function at higher glucose levels

A

Not inhibited by glucose 6 phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Phosphorylation of glycogen phosphorylase (increases or decreases) glycogen degradation

A

Increases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What inhibits pyruvate dehydrogenase complex

A

Acetyl CoA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pyruvate kinase activated by what allosterically

A

Fructose 1,5-bisphosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What enzyme turns pyruvate to oxaloacetate

A

Pyruvate carboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

If AMP is high and ATP is low what occurs

A

Glycolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HK 1 is expressed where

A

All tissues to different levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

glucokinase is expressed where

A

Liver and pancreatic B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Why does pyruvate kinase becomes inactivated

A

Glucose depletion in liver only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Characteristics of hexokinase

A

Present in all tissues, high affinity for glucose, low Km, low Vmax, inhibited by glucose 6 phosphate, constitutive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the branches of glycogen

A

Alpha 1-4 and alpha 1-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What inhibits FBPase-2

A

Phosphoprotein phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Fructose 2,6-bisphosphate is produced from

A

Fructose 6-phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Synthesis of glycogen starts as

A

Glucose 6 phosphate to glucose 1 phosphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Deficiency in cori disease

A

4:4 transferase, or 1:6 glucosidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Function of Glut 2

A

In pancreas, regulation of insulin. In liver, removes excess glucose from blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What levels of ATP stimulate glycogen phosphorylase activity

A

Low ATP levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Glycogen is a polymer of

A

Glucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

In pompe disease, what deficiency leads to accumulation of glycogen in lysosomes

A

Lysosomal alpha 1-4 glucosidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What inactivated PFK2

A

CAMP dependent protein kinase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What enzyme is used in glycogenolysis

A

Glycogen phosphorylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the deficiency in von gierke disease

A

Glucose 6 phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

How do the glycosidic bonds in glycogen cleave during glycogenolysis

A

Cleavage of alpha 1-4 glycosidic bonds from non reducing end until 4 residues from branch point

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What turns glucose one phosphate into UDP glucose

A

UDP pyrophosphorylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Glucokinase kM
Higher so responsive to higher concentrations of glucose
26
Comment of Glut 4
Amount in muscle plasma membrane increases with endurance training
27
ATP regulates what enzyme
Phosphofructokinase-1
28
Function of glucokinase
Clear blood glucose at higher concentrations of glucose for storage as glycogen
29
What activates FBPase2
CAMP-dependent protein kinase
30
What enzyme needed to make F2,6 bisphosphate
PFK-2
31
What acts as an allosteric activator in glycogen synthase in the liver and muscle
Glucose 6 phosphate
32
What protein serves as a nidus for glucose to attach and acts as an enzyme (glycogen synthase activity) to form a linear poly glucose chain containing at least 8 glucose units to serve as a primer for glycogen synthas
Glycogenin
33
Cofactor for glycogenolysis
Pyridoxal phosphate
34
What activates cAMP dependent protein kinase
Glucagon
35
What enzyme turns pyruvate into acetyl CoA
Pyruvate dehydrogenase complex
36
What are isozymes
Different enzymes that catalyze the same reaction
37
If AMP is low and ATP high what occurs
Gluconeogenesis
38
What is ATP in the commitment step in glycolysis
Substrate and negative effector
39
Glycogen synthase requires
Glycogenin
40
Glucose one phosphate becomes what in glycogenesis
UDP glucose
41
Function of Glut 5
Fructose transporter
42
What are the two alternative fates of pyruvate
New glucose or acetyl CoA
43
Isozymes share similar
Sequences
44
What activates phosphoprotein phosphatase
Insulin
45
What are the linear form of glycogen
Alpha 1-4
46
Size of glycogen
10^8 daltons
47
Why do we not spend glucose in glycolysis
If there is plenty of ATP
48
Tissue location of Glut 5
Small intestine
49
Function of glycogen synthase
Elongation of glycogen fragment
50
Deficiency in McArdle syndrome
Myophosphorylase
51
Characteristics of glucokinase
Present in liver and pancreatic B cells, high Km, high Vmax, responds to changes in glucose concentrations, induced by insulin
52
What is the allosteric inhibitor of glycogen phosphorylase in the liver and muscle
Glucose 6 phosphate and ATP
53
What is the branching enzyme for glycogenesis
4:6 transglucosidase activity
54
Function of fructose 2,6-bisphosphate
Regulate glycolysis and gluconeogenesis
55
Function of glycogenin
Synthesis of primer
56
What are the three targets of insulin in myocte
Glut 4, hexokinase and glycogen synthase
57
Fructose 2,6-bisphosphate inhibits
1,6-bisphosphatase (gluconeogenesis)
58
Liver glycogen is used for
Blood glucose homeostasis
59
Tissue location of Glut 2
Liver and pancreatic B cells
60
What is the coenzyme for pyruvate carboxylase
Biotin
61
What activates pyruvate carboxylase
Acetyl CoA
62
If pyruvate becomes acetyl CoA it can
Store energy as body fat, make ATP via citric acid cycle
63
How to make fructose 6-phosphate from F2,6BP
FBPase-2
64
Pryuvate kinase allosterically inhibited by
ATP, acetyl CoA, long chain fatty acids and alanine
65
Fructose 2,6-bisphosphate is not
A glycolytic intermediate but a regulator
66
If pyruvate becomes glucose it can
Store energy as glycogen, generate NADPH vie pentose phosphate pathway
67
Product of glycogenolysis
Glucose one phosphate and shortened glycogen fragment (limit dextrin)
68
Acetyl CoA stimulates what
Glucose synthesis by activating pyruvate carboxylase
69
What activates PFK2
Phosphoprotein phosphatase
70
Muscle glycogen is used for
Fuel reserve for ATP synthesis
71
Tissue location of Glut 4
Muscle and fat cells
72
What is the commitment step in glycolysis
Fructose 6 phosphate to fructose 1,6-bisphosphate
73
Fructose 2,6-bisphosphate activates
Phosphofructokinase (glycolysis)

Biochem 2 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions