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Flashcards in Uterine Malignancy EZ Deck (18)
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1

Possible cause of endometrial hyperplasia

Oestrogen stimulation

2

Atypical hyperplasia is the precursor for which type of cancer

Endometriod cancer

3

Serous intraepithlial carcinoma is the precursor for which type of cancer

Serous cell carcinoma

4

If a young person gets endometrial carcinoma, what underlying conditions should you consider?

PCOS
Lynch syndrome

5

Most endometrial carcinomas are which type of cancer?

Adenocarcinoma

6

Why is obesity linked with endometrial cancer?

Adipocytes convert ovarian androgens into estrogens

7

Lynch syndrome increases risks of which types of cancer?

-colorectal
-ovarian
-endometrial

8

Lynch syndrome inheritence

Autosomal dominant

9

How can you identify tumours due to Lynch syndrome

Immunohistochemistry staining for mismatch repair proteins

-you can also test cancer tissue for microsatellite instability

10

Endometrial stromal sarcoma arises from where?

Arises from the endometrial stroma

-they infiltrate the myometrium and often the lymphovascular spaces

11

This is a mixed tumour with malignant, epithelial and stromal elements

Carcinosarcoma

12

How do endometrial stromal sarcomas present?

Often present with abnormal uterine bleeding but can present as metastases (usually ovary or lung)

13

Most important prognostic factor in endometrial stromal sarcoma?

Stage

(endometrial carcinoma prognosis depends on stage, histological grade and depth of myometrial invasion)

14

The presence of a rhabdomyosarcomatous component in a carcinosarcoma has what kind of prognosis?

The worst prognosis

15

This smooth muscle tumour is associated with menorrhagia and infertility

Leiomyoma

16

What type of cells are seen in leiomyosarcomas?

Spindle cells

17

This is the most common uterine sarcoma

Leiomyosarcoma

(most common uterine SARCOMA, still on represent 1-2% of uterine sarcomas)

18

How might a leiomyosarcoma present?

-abnormal uterine bleeding
-palpable pelvic mass
-pelvic pain