UWorld 2

Question 1

the Power of a study

Answer 1

= 1 - beta

beta is the type 2 error– % likelihood find something where there’s nothing

Question 2

surgery for carpal tunnel- cut what?

Answer 2

flexor retinaculum = transverse carpal ligament

Question 3

if HBeAg stays present

Answer 3

chronic hep b infection with high infectivity

Question 4

very long chain fatty acids metabolized where?

Answer 4

peroxisomes

Question 5

what comes from ventral pancreatic primordium?

Answer 5

main pancreatic duct

Question 6

telomerase

Answer 6

adds TTAGGG to 3’ end

extra in stem cells, e.g. epidermal basal cells

Question 7

tetrology of fallot

Answer 7

cyanotic spells, squatting, systolic murmur

from deviation of infundibular septum

Question 8

increased pulmonary wedge pressure means

Answer 8

increased LA pressure, e.g. mitral valve stenosis

Question 9

x-linked agammaglobulinemia

Answer 9

lower or no CD 19+/ 20+ b cells, pan-hypogammaglobulinemia

Question 10

anterolateral vs medial humeral fracture–>

Answer 10

anterolateral –> radial n. injury

anteromedial–> median nerve injury

Question 11

lung regeneration cells

Answer 11

type 2 pneumocytes

Question 12

EHEC toxin

Answer 12

shiga-like

inactivate 60s ribosomal subunit

Question 13

HPV also infects

Answer 13

true vocal cords

Question 14

where does ADH act?

Answer 14

medullary segment of collecting duct

Question 15

adenoyosis

Answer 15

endometrial glandular tissue in myometrium

• heavy bleeding
• dysmennorrhea
• uniformly enlarged uterus

Question 16

Slow SA node w/out impacting contractility or relaxation. What channels?

Answer 16

funny sodium- phase 4

Question 17

ureteral injury presents with

Answer 17

flank pain and fever

Question 18

Fabry disease

Answer 18

X linked recessive
lipid storage disorder
alpha glactosidase deficiency
--> decreased breakdown of Gb3 (globotriaosylceramide)
--> neuropathy, hypohidrosis
angiokeratomas/ telangiectasias
cerebrovascular/ cardiac trouble

Gb3 buildup in glomerulus and distal tubule–> proteinuria, polyuria, renal failure

Question 19

fetal hemoglobin

Answer 19

alpha 2 gamma 2

Question 20

ataxia telangiectasia defect

Answer 20

DNA break repair

Question 21

tetanus suppressus

Answer 21

glycine and GABA

Question 22

corticosteroids and neutrophiles

Answer 22

increases counts due to demargination

Question 23

strongyloides stool finding

Answer 23

Rhabditiform larvae

Question 24

Hep C virus genetic instability due to

Answer 24

no proofreading 3’ to 5’ exonuclease activity

Question 25

Cheyne-Stokes breathing

Answer 25

seen in CHF

hyperventilation–> Apnea–> small-big-small tidal volumes

Question 26

cyclosporine and tacrolimus MOA

Answer 26

immunosuppression by inhibiting calcineurin activation

Question 27

homocysteine metabolism

Answer 27

• -> methionine OR

- -> cystathionine via methylene tetrahydrofolate reductase

Question 28

hydroxyurea does what?

Answer 28

stimulates Hb F synthesis (sickle cell)