Vaccines Flashcards Preview

Pharmacology Part 2 > Vaccines > Flashcards

Flashcards in Vaccines Deck (11):
1

Vaccines MOA

Vaccines act as antigen to stimulate the immune system to produce antigen specific antibodies

2

Live attenuated (weakened) vaccines

Modified to be less pathogenic
Most consistent with natural immunity
-retains ability to replicate
*cannot give to immunocompromised PTs
-more effective, longer lasting

3

Inactivated (killed) vaccines

Non infectious, no replication
Ig levels fall over time: boosters needed
*safer in immunocompromised patients
*may cause more AEs due to adjuvants

4

Adjuvants

More in inactivated vaccines
Things added to vaccine; intended to make body angry and to build an immune response
Al3, water, oil

5

After systemic corticosteroids wait how long to administer a live vaccine?

One month

6

After stopping other immunosuppressants wait how long to give a live vaccine?

3 months

7

Thimerosal

Preservative
-Mercury(neurotoxic)
Removed in 1999 from childhood vaccines
.01% still in vaccines

8

Vaccine Adverse Effects

Pain,redness, arthralgia at site of injection
-fever, febrile seizures
*intussusception( rotavirus vaccine)- GI issues, obstruction in newborns
*narcolepsy- Europe H1N1

9

Beyond vaccination
Other immune enhancing agents

-Colony stimulating factors
-IVIG

Specific: antibodies given against disease for when you already have it

10

Colony stimulating factors
G-CSF: Filgrastim (neupogen), Pegfilgrastim (Nuelasta)
GM-CSF: Sargramostim (leukine)

Make bone marrow make specific cell types (used in people who are immunosuppressant)
Low risk of infection

IVIG: pooled immunoglobulin (IgG) from the population (tightly controlled and very expensive)

11

Specific antibodies to get when you already have the disease

Anthrax, botulism, CMV, hep B, rabies, Rh0, tetanus, varicella-zoster