Valvular Defects Flashcards

1
Q

What causes aortic stenosis

A

Degeneration - high BP / atherosclerosis = most common >65
Congenital bicuspid (most common in <65)
Rheumatic
- Do ASO titre if suspect
William’s
- Supra-valvular AS

SLE / Paget / infection

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2
Q

What are the DDX of AS

A

HCM
- Usually younger
Aortic sclerosis
Angina

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3
Q

What is the murmur in aortic stenosis

A

Ejection systolic
Radiates to carotid and back
Heard over aortic

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4
Q

What is aortic sclerosis

A

Calcification
Ejection systolic murmur
No radiation
Normal pulse

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5
Q

What are the symptoms of aortic stenosis

A
Long asymptomatic
Symptoms on increased O2 demand / exertion 
Chest pain
Angina
Syncope
SOB
Dizzy
Leads to HF
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6
Q

What are signs of aortic stenosis

A
Small volume pulse
Slow rising as blood can't get through in carotid (pulsus tarsus) 
Narrow pulse pressure
Vigourous apex beat 
Soft and split S2
S4 gallop - heard just before S1
- Due to stiff ventricle 
(If S3 think HF) 
Thrill
RH failure - JVP / RV heave 
LV heave
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7
Q

How do you investigate aortic stenosis

A
Refer for ECHO + doppler ECHO
ECG
- Abnormal in 90% 
- LVH due to overload
- May get P-mitrale, LBBB, AV block 
CXR 
- Valve calcifcation
- Enlarged LV
- Pulmonary congestion 

2nd line if inconclusive
Angiogram
Cardiac MI

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8
Q

What does ECHO look at

A
Cusp mobility
Lv function and hypertrophy
Pressure gradient 
Vegetations 
Calcification
Assess EF
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9
Q

How does ECHO assess EF

A

Haemodynamic assessment
Pressure gradient / flow through valve
Should not have difference
If low EF = very serious

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10
Q

Why do you do angiogram

A

Check carotids before surgery as. might have CAD

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11
Q

How do you treat aortic stenosis and when should you consider Rx even if not symptomatic

What do you avoid

A

Monitor
Can give furosemide
AVOID nitrates / CI as will drop BP and reduce perfusion
Treat as soon as symptomatic or if detonating ECG / >40mmHg pressure gradient / EF <50%

Open Valve replacement or repair = 1st line in the young

TAVI - via femoral (better tolerated in elderly / frail)

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12
Q

What do you do if can’t repair

A

Balloon valvuloplasty

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13
Q

What happens after op

A

Chest drain

Pacing and sensor wires

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14
Q

What are risks of aortic stenosis

A

IE + Embolus if IE
LV hypertrophy - all patients will have
Heart failure

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15
Q

How does LVH and what are the consequences

A

Increased pressure due to stenosis
Backs into pulmonary circulation
Increased O2 demand as more muscle once hypertrophy
Can lead to ischaemia and LV failure

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16
Q

What is CI in aortic stenosis

A

ETT
Nitrates / GTN - if patient has exertional dyspnoea and suspect AS never give
BB as will reduce HR and output

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17
Q

What are the risks of surgery

A
Infection 
Arrhythmia
MI 
Stroke
Reduced kidney
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18
Q

What causes acute aortic regurgitation

A

IE
Aortic dissection
Chest trauma

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19
Q

What causes chronic aortic regurgitation

A
Connective tissue = most common (Marfan's or Ehler danlos) 
Congenital bicuspid 
Hypertension
Rheumatic fever
Endocarditis 
RA / SLE
Syphilis
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20
Q

What murmur is in AR and what happens

A

Early diastolic murmur

Diastolic leakage of blood from aorta back into LV
Dilates the heart rather than hypertrophy so get displaced beat

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21
Q

How does AR present

A

If acute = medical emergency

  • Sudden pulmonary oedema
  • Hypotension / shock
  • Can present as MI or dissection
Present like HF / angina
Dyspnoea
Orthopnoea
PND
Palpitations 
Syncope
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22
Q

What are the signs of AR

A
Large volume collapsing pulse as blood flows back 
- Forceful then disappears 
Wide pulse pressure
Displaced apex
Head nodding with pulse = De Musset
Visible pulsation in nail bed
Femoral pistol shot on auscultation
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23
Q

How do you investigate AR

A
ECHO = diagnostic 
ECG 
- LVH strain 
CXR - cardiomegaly / hypertrophy / dilated aorta
Angiogram
Ghent criteria for marfan
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24
Q

How do you treat AR

A

If EF >50% = reassure otherwise treat
Reduce systolic
- ACEI + ARB useful esp if Marfan
Vasodilator = very important
- Nifedipine + hydrazine
ECHO 6-12 months
Treat underlying cause
Surgery if symptomatic and severe asymptomatic
- Transcatherer aortic valve implantation
If Marfan may get prophylactic aortic root

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25
When is surgery indicated
Severe AR (whole LV filled after one diastole) Increasing symptoms Enlarging LV
26
What are the complications of AR
LV has to accommodate SV + regurg volume If acute poorly tolerate as no time for wall to adapt Increased EDV and pressure = hypertrophy HEART FAILURE
27
What suggests poor outcome
EF <50% CCF >12 months NHYA Class III or IV
28
What causes mitral regurgitation (blood back through mitral in systolic contraction)
Degeneration Post MI IE as vegetation prevent closure (if MR + fever) Rheumatic but more classically cause stenosis Connective tissue - Marfan / Ehlor Mitral valve prolapse LV dilatation as pulls leaflet apart = functional regurgitation - Cardiomyopathy - MS treatment
29
What are the symptoms of MR
``` Asymptomatic until LV begins to fail when SV and CO can't be maintained Then leads to CCF Fatigue SOB Palpitations Oedema Hypotension Pulmonary oedema and hypertension Arrhythmia Cariogenic shock ```
30
What type of murmur in MR
Pansystolic murmur High pitched whistle due to high velocity Radiates to apex
31
What are signs of MR
``` Displaced apex due to dilatation of LV Split S2 and reduced S1 (MS has loud S1) Pulse is normal or reduced AF develops as LA dilates RHF develops = JVP + heave HF signs if develop ```
32
How do you investigate MR
ECHO - MR severity, flow into pulmonary vein ECG CXR - cardiomegaly / calcification Aniogram
33
What is shown on ECG and on ECHO
LA dilatation so PR >0.12 ECHO - MR severity - Larger LV and dilated LA - EF is often under-estimated as some blood going into LA in systole (so if 55% and 5 goes into LA really 50%)
34
How do you treat acute MR
``` Reduce preload and after load Nitrate Diuretic Inotrope Na nitroprusside ?? ACEI / BB / spironolactone - if in HF Treat AF and anti-coagulate Surgery if severe ```
35
What is better for repair
Repair better than replacement
36
What are the affects of acute MR
Ventricle doesn't have time to compensate | ESP and EDV decrease to decrease wall tension
37
What happens in chronic MR
``` EDV and ESV return to normal LV hypertrophy to accommodate extra blood Heart becomes less efficient More severe = moer hypertrophy HEART FAILURE ``` Surgery if EF falls or significant LV dilatation on ECHO or symptoms Otherwise treat AF - Can't do rhythm as LA dilated
38
What is the most common valve abnormality overall
Mitral valve prolapse - Very common in young girls - As get older AS more common
39
What causes MVP
``` ASD PDA Cardiomyopathy Turner Marfan Osteogenesis imperfecta WPW ```
40
What are the symptoms of MVP
``` Asymptomatic Aytypical chest pain Palpitations Autonomic Sx Late systolic due to sudden stretch of chordae or prolapsed leaflet Low volume pulse ```
41
How do you Dx
ECHO | ECG
42
How do you treat MVP
BB for palpitation / chest pain | Surgery if severe
43
What are complications of MVP
Can progress to MR Emboli Arrythmia Sudden death
44
What causes mitral stenosis
``` Congenital Rheumatic HD !!!!! Other rheumatic - SLE / RA Infective endocarditis Carcinoid - more effects R side of heart but can affect L if mets in lung ```
45
What is the murmur like in MS
``` Mid-diastolic Rumbling Difficult to hear - Should be no sound before Lub dub - RRRR lub dub ```
46
What are the symptoms of mitral stenosis
``` Pulmonary hypertension Pulmnary oedema Heart failure SOB Haemoptysis Chronic bronchtiis Fatigue Palpitations Tachycardia - worse on exercise / illness ```
47
What are the signs of MS
``` Loud S1 as large force needed to shut Tapping apex beat Rumbling murmur after JVP RV heave Diastolic thrill Malar flush - Sign of low CO state due to pulmonary HTN = vasodilatation Normal pulse - may have low volume AF - any problem causing LA dilatation Signs of pulmonary HTN ```
48
What arrhythmia is common
AF due to LA dilatation
49
How do you Dx MS
ECG - RVH / P mitrale (bifid P wave) if sinus and AF if not CXR - RVH / oedema / LA enlargement ECHO = diagnostic Angiogram
50
How do you treat MS
Manage AF Diuretic to reduce preload and afterload and for pulmonary oedema Valve repalcement = gold standard - Can be difficult if pulmonary HTN developed
51
What are the complications of MS
Tight MV = pressure increases in LA and dilates Embolization due to LA enlargement Hoarse voice - LA presses on recurrent laryngeal rare Bronchial obstruciton / dysphagia IE Increased pressure goes into PV and PA = RV hypertrophy Pulmonary HTN and cor-pulmonale
52
What does severity of valve depend
Trans valvular Flow rate | Pressure
53
What causes an ejection systolic murmur
``` Aortic stenosis Pulmonary stenosis HCM ASD Tetrology of fall out ```
54
What causes pansystolic murmur
Mitral regurgitation Tricuspid regurgitation VSD
55
What causes late systolic
MVP | Coarctation
56
What causes early diastolic
Aortic regurgitation | Pulmonary regurgitation
57
What causes Late diastolic
Mitral stenosis Severe aortic regurgitation Anything obstructing mitral orifice - thrombus / myxoma
58
What causes continuous murmur
PDA
59
R sided murmur
Do if have time
60
Tricuspid regurgitation
Cor pulmonale - pan-systolic
61
How do you describe murmur
``` SCRIPT Site Character Radiation Intensity Pitch Timing Grade 1-6 (1 hard to hear, 6 can hear without stethoscope)V ```
62
What does regurgitation cause
Dilatation
63
What does stenosis cause
Hypertrophy
64
What type of surgery for heart valve
Usually sternotomy scar (also CABG) Open heart surgery = remains 1st line if young nd fit TAVI
65
What type of valve
Bio | Mechanical
66
Bio valves
10 years No anti-coagulation Better in elderly
67
Mechanical valve
20 years Life long anti-coagulation with warfarin Target INR = 2.5-3.5
68
What are complications of valve
Thrombus Embolism IE Haemolysis
69
Where do you hear click in cardiac cycle
S1 if mitral | S2 if aortic
70
What causes a 3rd HS
``` Rapid ventricular emptying Physiological if <30 Typically LVF Dilated cardiomyopathy Constrictive pericarditis MR ```
71
What causes a 4th HS
Due to atrial contraction against stiff ventricle (suggest L ventricle hypertrophy) Aortic stenosis HOCM Hypertension
72
What makes a murmur quieter
L ventricle systolic dysfunction as reduced flow rate
73
What can you not grade murmur on
Loudness | Need ECHO to assess valve function
74
how does valsalva affect murmur
Valsalva reduces the peripheral pressure Heart fills with more blood and hence the chamber opens up Means the narrowing at the level of the aortic valve is reduced so the murmur is quieter
75
Most common valve defect
AS and MR
76
What causes a double impulse apex
HOCM due to massive left atrium
77
What can cause valves in R side of heart to stenose
Carcinoid syndrome | - If Hx flushing / wheeze / diarrhoea
78
How does it rarely present in L
If tumour has mets in lung so go into pulmonary vascular and to L side of heart
79
R side murmur
Louder inspiration
80
L side murmur
Louder expiration
81
What can cause clubbing
All congenital heart - Tetrology, ASD, VSD, PDA IE