Valvular Defects Flashcards
What causes aortic stenosis
Degeneration - high BP / atherosclerosis = most common >65
Congenital bicuspid (most common in <65)
Rheumatic
- Do ASO titre if suspect
William’s
- Supra-valvular AS
SLE / Paget / infection
What are the DDX of AS
HCM
- Usually younger
Aortic sclerosis
Angina
What is the murmur in aortic stenosis
Ejection systolic
Radiates to carotid and back
Heard over aortic
What is aortic sclerosis
Calcification
Ejection systolic murmur
No radiation
Normal pulse
What are the symptoms of aortic stenosis
Long asymptomatic Symptoms on increased O2 demand / exertion Chest pain Angina Syncope SOB Dizzy Leads to HF
What are signs of aortic stenosis
Small volume pulse Slow rising as blood can't get through in carotid (pulsus tarsus) Narrow pulse pressure Vigourous apex beat Soft and split S2 S4 gallop - heard just before S1 - Due to stiff ventricle (If S3 think HF) Thrill RH failure - JVP / RV heave LV heave
How do you investigate aortic stenosis
Refer for ECHO + doppler ECHO ECG - Abnormal in 90% - LVH due to overload - May get P-mitrale, LBBB, AV block CXR - Valve calcifcation - Enlarged LV - Pulmonary congestion
2nd line if inconclusive
Angiogram
Cardiac MI
What does ECHO look at
Cusp mobility Lv function and hypertrophy Pressure gradient Vegetations Calcification Assess EF
How does ECHO assess EF
Haemodynamic assessment
Pressure gradient / flow through valve
Should not have difference
If low EF = very serious
Why do you do angiogram
Check carotids before surgery as. might have CAD
How do you treat aortic stenosis and when should you consider Rx even if not symptomatic
What do you avoid
Monitor
Can give furosemide
AVOID nitrates / CI as will drop BP and reduce perfusion
Treat as soon as symptomatic or if detonating ECG / >40mmHg pressure gradient / EF <50%
Open Valve replacement or repair = 1st line in the young
TAVI - via femoral (better tolerated in elderly / frail)
What do you do if can’t repair
Balloon valvuloplasty
What happens after op
Chest drain
Pacing and sensor wires
What are risks of aortic stenosis
IE + Embolus if IE
LV hypertrophy - all patients will have
Heart failure
How does LVH and what are the consequences
Increased pressure due to stenosis
Backs into pulmonary circulation
Increased O2 demand as more muscle once hypertrophy
Can lead to ischaemia and LV failure
What is CI in aortic stenosis
ETT
Nitrates / GTN - if patient has exertional dyspnoea and suspect AS never give
BB as will reduce HR and output
What are the risks of surgery
Infection Arrhythmia MI Stroke Reduced kidney
What causes acute aortic regurgitation
IE
Aortic dissection
Chest trauma
What causes chronic aortic regurgitation
Connective tissue = most common (Marfan's or Ehler danlos) Congenital bicuspid Hypertension Rheumatic fever Endocarditis RA / SLE Syphilis
What murmur is in AR and what happens
Early diastolic murmur
Diastolic leakage of blood from aorta back into LV
Dilates the heart rather than hypertrophy so get displaced beat
How does AR present
If acute = medical emergency
- Sudden pulmonary oedema
- Hypotension / shock
- Can present as MI or dissection
Present like HF / angina Dyspnoea Orthopnoea PND Palpitations Syncope
What are the signs of AR
Large volume collapsing pulse as blood flows back - Forceful then disappears Wide pulse pressure Displaced apex Head nodding with pulse = De Musset Visible pulsation in nail bed Femoral pistol shot on auscultation
How do you investigate AR
ECHO = diagnostic ECG - LVH strain CXR - cardiomegaly / hypertrophy / dilated aorta Angiogram Ghent criteria for marfan
How do you treat AR
If EF >50% = reassure otherwise treat
Reduce systolic
- ACEI + ARB useful esp if Marfan
Vasodilator = very important
- Nifedipine + hydrazine
ECHO 6-12 months
Treat underlying cause
Surgery if symptomatic and severe asymptomatic
- Transcatherer aortic valve implantation
If Marfan may get prophylactic aortic root