vascular biology 2 and 3 Flashcards Preview

cell bio test 3 > vascular biology 2 and 3 > Flashcards

Flashcards in vascular biology 2 and 3 Deck (62):
1

what are the componets of the tunica medial

lesss connective tissue lots of musclualr tissue

2

if you see prominent internal and external elastic membran what are you looking at

a muscular artery

3

what are the changes associated with changes in aging of musclualr artery

thicking of the tunica intima, some reorganixzation of the elastic membrane. Later even more intima less media

4

if the wall to lumen ration is 1 to 1 what are you looking at

an arteriole

5

how is blood directed in capilaires

sphictor muscles

6

how big is the luman of a caplilairy compared to a reb blood cell

just slightly larger to allow it ot leave

7

what are the three types of capillaires

contiuious, fenestrated , sinusoid

8

what is a pericyte

embraces the endothylium of campliary contractile cells help pump and can become smooth muscle or fibroblasts, is a mesencylmal cells

9

what kind of connections do dontinous capullaries have

tight junction between cells

10

what forms a trans endothelouim chanal in continous capillaires

large numbers of vessicles of endocytoic vessels not leaky fluid

11

how is the basal lamina in encitnous capillaires

continous

12

where do you find continous caplilliares

brain muscle connective tissue and exocrine glands

13

where do you find fenestrated capilliires

in the kidneys endocrine glands int3estines

14

how are the pores closed in a fenestraed caplilaires

by a thin diaphram

15

how is the basal lamina in fenestrated capillaires

continous

16

what is distinicitive about sinosoidal capiliaries

basal mambrane absent or discontinous or absent and large pores

17

where is the sinusoidal caplilliares found

in the liver red bone marrow spleen andrenal cortex very large door areas of great exchange

18

what are pericytic venules

the smallest veins

19

what is the differnce between a venoual and a arterieol

very small limuen porus

20

when pericutic venuals join up what do they form

muscular venules

21

why are leaky venuals during inflamation benificial

they allow the movement of luekocytes into the epithilium by passing throught the intercellular junction

22

what do small veins have that its precursors don’t

smooth muscles, and leaflets that

23

what do the leaflets do in veins

they function as valves to close the viens when blood flows in the wrong direction.

24

compared to a artiery how is the tunica media and tunica adventidia

vien tunica media smaller tunica adventicia much larger

25

what changes in the large or protal veins svc …ect

in the tunical adventitila you see longitudanl arrengment of the muscle helps to propel blood forward.

26

what is casulogensis

de novo vessle formation

27

what is angiogenisis

growth from existing ec derived channels

28

whant is arteriogensis

formation of arterie arterieo and collateral vessel remodeling

29

neocastulaization

inclides all three genisis terms

30

what do epc does

enodotheluil precursor bone marrow one suours respond to hormones

31

what are the three functions of EPC

replace lost enotheluial cells, re endothelization of zascular implants, neovascularixation of organ wounds and tumors

32

what are the steps in blood vessel formation from preexisting blood vessles

Vasodilation due to NO and increased vascular permeability induced by VEGF of pre-existing (parent) vessel ii. Proteolytic degradation of the basal lamina of the parent vessel by metalloproteinases. Endothelial cells must shed their cell-to-cell contacts (intercellular junctions). This loss of cell-to-cell contact is mediated by plasminogen activator. iii. Migration and proliferation of endothelial cells which have disrupted their cell-to-cell contacts. The migration and proliferation is induced by proangiogenic factors (e.g., VEGF and angiopoietin 2). Fibroblast growth factor-2 can also mediate endothelial cell migration and proliferation. iv. Endothelial cells mature into an endothelial capillary tube. v. Elaboration of basal lamina and recruitment of periendothelial cells. (pericytes for capillaries and pericytic venules and smooth muscle cells for larger vessels). Elaboration of basal lamina elements is mediated by TGF-β (tumor growth factor). Recruitment of periendothelial cells is mediated by the interaction of Ang 1 with the Tie2 receptor on endothelial cells. PDGR (platelet-derived growth factor) induces recruitment of smooth muscle cells. Angiopoietin (Ang) 2 is involved in the stabilization process. Ang2 bound to Tie2, in the absence of growth factors, makes the endothelial cell more responsive to antiangiogenic factors.

33

what marker is associated with tumor growth

TEM8 rumor endothelia marker 8

34

what is makes the great saphenous vein suitible for an arterioral bypass

large tunica media with circular musles and longituidinal muscles

35

what hapends to a vessel with inceased blood flow

and incerase tin the outside and inside diamater but no increase I the wall size itself

36

what hapends to a vessel with deceased blood flow

oustide and inside diamter get small and wall thickness does get smaller as well.

37

what happends to a large vessel during increased pressure

wall thickness increased wall thiknces incerase from the outside the luman diameter unchanges

38

what happends to a small vessel during increased pressure

wall thickness inceased from the inside

39

endocarduim of the heart corresonds to what layer of the blood vessels

tunica intima

40

what are the four layers of the endocarduim

endothelium simple squamous, subendothelial, myoelastic lsayer smooth much als elastic collagen fibers, and subendocarium made of loos CT small bood vessels nerve fibers and purkinje cells in ventricles.

41

what are the three types of cariocytes (tunica media)

contractile myoednocrine and conductive

42

what do the meoendocrine cells release

atrial natriuretic factor , be tyope natruietic dactor, diuresis and casodiliatioin,

43

what type endocrine in the heart is incresased with heart faul

B type is elevated

44

what is the vessel comparison of epicarduim

tunica advertitia

45

what can you find in the epicaruim

meothelium simple squamous and basal lamina and subepicardium

46

what connects the cardiad muscle and the valves are anchored

cariac skeleton

47

what does the fibrous skeleton insulate

the ventricles from the atruim so the pulse wont go from one to another

48

what structures are found in the caridac skeleton

annuli fibrosa trigona fibrosa and septum membranaceum

49

what are three layers of the AV valves

atrialis layer of elastid collagen contracts the valve, Spongiosa loose CT shock absorber, Fibrosa core of dense irregular CT mechanical integrity

50

what are the layers of the semilunar valves

fibrosa desnse irregular CT faces the great artery, spongiosa middle layer, and ventricularis venticular surface.

51

what percent of the SA node is lost by humans by age 80

90%

52

Sa nodel cells compared to atrial muscle cells are ?

smaller

53

Bundle of his cells or perinje cells are what compared to atrial muscle cells

larger

54

compared to ventricular muscles what is the glycogen content

more glycogen

55

how many times does the heart muscle cells replace during a lifetime

10-15 times

56

where are the cardiac stem cells and early committed cells reside

AV sulcas

57

does a lymphatic capillary have a basal lamina

no or if yes its incomplete

58

descrive lymphatic caplillaries

thin blind ended anchoring fibrils basal lamina incomplete no pericytes and smooth msucles cells are absent. Single layer of endothelial cells

59

how can you tell the diffence between a vein and a lymph vessel

no red blood cells

60

do lymphatic vessles have valves

yes

61

lymphatic ducts describe them

smooth muscle is found casa vasorum and overabundance can indicate malignant tumor

62

what is a aschoff body

a focus of lymphocytes plasma cells and macrophages.