Flashcards in Vasculitic Syndromes Deck (46)
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1
Giant cell arteritis- epidemiologies
females of north european descent, >50
2
Giant cell arteritis- Sx
it's in the temporal artery so headaches, jaw pain, blurry/double vision
3
Giant cell arteritis- Dx
bilateral temporal artery biopsy, increase in ESR, multinucleated giant cells
4
Giant cell arteritis- Tx
prednisone
5
Takayasu arteritis- what is it
also known as aortic arch syndrome or pulseless disease. Vasculitis causes an inflammation which damages the aorta and the its main branches leading to arterial stenosis or aneurysms.
6
Takayasu arteritis- patient population
females between 15 and 40 years old in Asia, Latin America, and Eastern Europe
7
Takayasu arteritis- Sx
abscence of peripheral pulses, ischemia to head, fever, vascular bruits
8
Takayasu arteritis- Dx
increase in ESR and aortic arch thickening
9
Takayasu arteritis- Tx
Corticosteroids
10
What is pylyarteritis nodosa (PAN)?
vasculitis of medium-sized vessels
11
Is PAN involved with glomerulonephritis?
No
12
What infection is PAN assocated with?
Hep B and C
13
PAN- Dx
increase in BUN and Hep B antigen
14
What is Microscopic polyangitis (MPA)?
vasculitis of small-sized vessels
15
Is MPA involved with glomerulonephritis?
Yes (+lung involvement)
16
MPA- Dx
Increase in P-ANCA
17
What are the diseases associated with secondary polyarteritis?
hepatitis C infection, rheumatoid arthritis, Sjogren syndrome, mixed cryoglobulinemia, hairy cell leukemia, myelodysplastic syndrome, and other hematologic malignancies
18
What is the confirmatory test used to demonstrate vasculitis?
Angiography or biopsy of involved tissue showing vasculitis
19
What are the agents used in the treatment of vasculitis?
Early diagnosis and corticosteroid therapy. Cytotoxic or antimetabolite drugs such as cyclophosphamide, methotrexate, and azathioprine are used in combination with corticosteroids
20
Churg Strauss vasculitis- why it's different than PAN
The presence of granulomas as well as the abundance of eosinophils distinguishes this disease from PAN
21
Churg Strauss vasculitis- population
males with a median age of 38
22
Churg Strauss vasculitis- Sx
1) a history of, or current symptoms of, asthma, 2) peripheral eosinophilia (>1.5 x 10^9 eosinophils/L), 3) systemic vasculitis of at least 2 extra-pulmonary organs.
23
Churg Strauss vasculitis- Dx
Granulomatous, necrotizing vasculitis w/ eosinophilia. Elevated IgE & ↑ P-ANCA
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Churg Strauss vasculitis- Tx
Corticosteriod w/ or w/o cytotoxic agents
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Buerger- population
young smokers
26
Buerger disease- Sx
ischemic injury to fingers and toes, can lead to amputation
27
Buerger disease- Tx
STOP SMOKING YOU IDIOT
28
Primary Angitis of CNS- cause
a form of vasculitis where the body attacks the arteries of the brain and spinal cord. It has a chronic fluctuating and progressive course
29
Primary Angitis of CNS- Sx
headache, maybe some mild CNS, rarely coma or stroke
30
