Flashcards in Vasculitic Syndromes Deck (46)
Giant cell arteritis- epidemiologies
females of north european descent, >50
Giant cell arteritis- Sx
it's in the temporal artery so headaches, jaw pain, blurry/double vision
Giant cell arteritis- Dx
bilateral temporal artery biopsy, increase in ESR, multinucleated giant cells
Giant cell arteritis- Tx
Takayasu arteritis- what is it
also known as aortic arch syndrome or pulseless disease. Vasculitis causes an inflammation which damages the aorta and the its main branches leading to arterial stenosis or aneurysms.
Takayasu arteritis- patient population
females between 15 and 40 years old in Asia, Latin America, and Eastern Europe
Takayasu arteritis- Sx
abscence of peripheral pulses, ischemia to head, fever, vascular bruits
Takayasu arteritis- Dx
increase in ESR and aortic arch thickening
Takayasu arteritis- Tx
What is pylyarteritis nodosa (PAN)?
vasculitis of medium-sized vessels
Is PAN involved with glomerulonephritis?
What infection is PAN assocated with?
Hep B and C
increase in BUN and Hep B antigen
What is Microscopic polyangitis (MPA)?
vasculitis of small-sized vessels
Is MPA involved with glomerulonephritis?
Yes (+lung involvement)
Increase in P-ANCA
What are the diseases associated with secondary polyarteritis?
hepatitis C infection, rheumatoid arthritis, Sjogren syndrome, mixed cryoglobulinemia, hairy cell leukemia, myelodysplastic syndrome, and other hematologic malignancies
What is the confirmatory test used to demonstrate vasculitis?
Angiography or biopsy of involved tissue showing vasculitis
What are the agents used in the treatment of vasculitis?
Early diagnosis and corticosteroid therapy. Cytotoxic or antimetabolite drugs such as cyclophosphamide, methotrexate, and azathioprine are used in combination with corticosteroids
Churg Strauss vasculitis- why it's different than PAN
The presence of granulomas as well as the abundance of eosinophils distinguishes this disease from PAN
Churg Strauss vasculitis- population
males with a median age of 38
Churg Strauss vasculitis- Sx
1) a history of, or current symptoms of, asthma, 2) peripheral eosinophilia (>1.5 x 10^9 eosinophils/L), 3) systemic vasculitis of at least 2 extra-pulmonary organs.
Churg Strauss vasculitis- Dx
Granulomatous, necrotizing vasculitis w/ eosinophilia. Elevated IgE & ↑ P-ANCA
Churg Strauss vasculitis- Tx
Corticosteriod w/ or w/o cytotoxic agents
Buerger disease- Sx
ischemic injury to fingers and toes, can lead to amputation
Buerger disease- Tx
STOP SMOKING YOU IDIOT
Primary Angitis of CNS- cause
a form of vasculitis where the body attacks the arteries of the brain and spinal cord. It has a chronic fluctuating and progressive course
Primary Angitis of CNS- Sx
headache, maybe some mild CNS, rarely coma or stroke