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MSK II > vasculitis > Flashcards

vasculitis Flashcards

1
Q

pathogenesis of vasculitis

A

ICs
Cā€™
necrosis and thrombosis

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2
Q

large vessel vasculitis symptoms

A 
limb claudication
asymmetric BP
absence of pulses
bruits
aortic dilation
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3
Q

medium vasculitis symptoms

A 
cutaneous nodules
ulcers
arthritis
livedo reticularis
digital gangrene
mononeuritis multiplex
microaneurysms
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4
Q

small vessel vasculitis symptoms

A 
purpura
urticaria
glomerulonephritis
alveolar hemorrhage
arthritis
granulomas
splinter hemorrhages
uveitis
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5
Q

large cell vasculitities

A 
Takaysu arteritis (TAK)
Giant cell arteritis (GCA)
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6
Q

medium vessel vasculitis

A 
polyarteritis nodosa (PAN)
Kawasaki disease (KD)
Buergers disease
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7
Q

small vessel ANCA assocaited

A

microscopic polyangitis (MPA)
granulomatosis with polyangitis (Wegengers)
eosinophilic granulomatosis with polyangitis (Churg strauss)

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8
Q

small vessel IC associated

A

anti-GBM (goodpastures)
cryoglobulinemic vasculitis (CV)
IgA vasculitis (Henoch-Schonlein and IgAV)
hypocomplimentemic urticarial vasculitis

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9
Q

vasculitis associated with systemic disease

A

SLE
rheumatoid vasculitis
sarcoid vasculitis

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10
Q

vasculitis associated with infections

A

Hep B, C
syphilis
CA

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11
Q

other vasculitities

A

drug induced either ICs or ANCA

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12
Q

Takayasus arteritis

A

aka pulseless disease
10 btwn arms
brutis

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13
Q

takaysus arteriogram

A

dilation, aneurysm or narrowing in aorta or main brr

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14
Q

Giant cell (temporal) arteritis

A

age >50

new cephalgia, jaw claudication, arm claudication, visual disurbances, neck pain, abdominal pain

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15
Q

polymyalgia rhematica

A

type of giant cell arteritis

stiffness and pain in shoulders and hips (NOT weakness)

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16
Q

giant cell arteritis tests

A

elevated ESR
increased AlkP
abnormal aa Bx (multinucleated giant cells)
CT, MRI, PET scans -> vascular edema and intimal thickening

17
Q

if temporal Bx is normal

A

must do MRI or CT angio for subclavian or axillary vessel narrowing
skip lesions- so might be missed

18
Q

if you see wrist or foot drop should think what?

A

this is mononeuritis multiplex

medium vessel vasculitis

19
Q

polyarteritis nodosa

A 
fever
wt loss
livedo reticularis, skin ulcers, nodules
lungs spared
testicular pain or tenderness
myalgias 
mono or poly neuropaty
may have heart or brain involvement
20
Q

kawasaki disease

A 
kids
fever for 5+days
strawberry tongue
erythematous rash- cheeks, palms, soles, 
cervical adenopathy 
conjunctivitis
21
Q

hypocomplementemic urticarial vasculitis aka

A

anti-C1q vascultitis

22
Q

hypocomplementemic urticarial vasculitis associated with

A

SLE

23
Q

hypocomplementemic urticarial vasculitis symptoms

A

wheals for >24 hours followed by ecchymosis

24
Q

what is essential mixed cryoglobulinemia associated with

A

hep C

sjogrens

25
Q

essential mixed cryoglobulinemia symptoms

A 
raynauds
cutaneous ulceration
cold-inducted urticaria
digital gangrene
polyarthralgias
purpura
nephritis
peripheral neuropathy
26
Q

henoch-schoenlein purpura

A 
purpura (100%)
arthritis (60-85%)
nephropathy (10-50%) -> casts
GI (85%) - ab pain w/bleeding
IgA ICs
kids
27
Q

ANCA associated diseases

A

aka pauci-immune

d/t white blood cells, Cā€™ secondary

28
Q

C-ANCA

A

wegners

29
Q

P-ANCA

A

churg-straus

microscopic polyangitis

30
Q

microscopic polyangitis

A

P-ANCA
NON-granulomatous
NO URT involvement
hemoptysis

31
Q

granulomatous polyangitis

A 
wegners
C-ANCA
stridor
URT symptoms
migratory arthritis
hemoptysis
RBCs or casts in urine
32
Q

churg-strauss

A

P-ANCA
eosinophils
mono or polyneuropathy
asthma

33
Q

Bechets syndrome

A

turkish/Mediterranean
oral and genital ulcers + occular involvement
affects aa and vv so symptoms can basically be anything
can be a cross reactions with strp
CD4
can be dt amyloidosis

34
Q

other symptoms of bechets

A

uveitis
arthritis
phelbitis
pathery- needle stick -> pustule

35
Q

familial mediterranean fever

A 
episodic fever
colchcine tx 
arthritis
abdominal pain 
erysipelas-like plaque around ankles
pyrin not suppressed
36
Q

simple organ vascultis

A

angiitis of CNS- string of beads

cutaneous leukocytoclastic vasculitis

MSK II (19 decks)

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