VBS 3 Pharm Flashcards
(21 cards)
Maropitant MOA
NK1 antagonist in the emetic center of the brain
- antiemetic
Maropitant ADME
A: SQ - rapid, almost complete, PO - limited by extensive first-pass
D:
M: liver
E: feces and urine
Pantoprazole MOA
Proton pump inhibitor
Inhibits transport of H+ ions into the stomach by forming bonds at H+/K+ ATPase
Buprenorphine Classification
Opioid
Partial Mu agonist, Kappa antagonist
Dexmedetomidine MOA
alpha-2 antagonist
- will decrease synaptic release of norepinephrine
- biphasic cardiovascular response of initial hypertension before hypotension
Benzodiazepine MOA
Potentiation of GABA - hyperpolarizes cells, making it more difficult to depolarize and excite
Diazepam MOA
benzodiazepine
longer duration of action than Midaz - so preferred in emergency situations
Propofol MOA
GABA agonist
Isoflurane
Carprofen MOA
COX2 inhibitor NSAID
Lidocaine MOA
inhibits initiation and conduction of action potentials by blocking voltage-gated sodium channels
- local anesthetic
Metronidazole MOA
DNA synthesis disruption
Metronidazole Classification
BacteriCIDAL
Activity against most obligate anaerobes
Metronidazole ADME
A: oral bioavailability high, absorption enhanced with food
D: LIPOphilic - widely distributed
M: liver
E: metabolites and unchanged drug in urine and feces
Dexmethasone
Glucocorticoid
- long acing, rapid onset
Prednisone
Glucocorticoid
Trilostane MOA
adrenal steroid synthesis inhibitor
competitive inhibitor of 3-Beta hydroxysteroid deoxyhydrogenase
DOCP Classification
Mineralocorticoid
Fludrocortisone Classification
Mineralocorticoid (primarily
Has SOME glucocorticoid activity
Hydrocortisone Classification
1:1 mineralocorticoid AND glucocorticoid
Glucocorticoid EFFECTS
- gluconeogenesis
- immune suppression via inhibition of leukocyte trafficking
- increase secretion of gastric acid, pepsin, and trypsin
- lipolysis
