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Block 6 > VBS 3 Pharm > Flashcards

VBS 3 Pharm Flashcards

1
Q

Maropitant MOA

A

NK1 antagonist in the emetic center of the brain
- antiemetic

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2
Q

Maropitant ADME

A

A: SQ - rapid, almost complete, PO - limited by extensive first-pass
D:
M: liver
E: feces and urine

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3
Q

Pantoprazole MOA

A

Proton pump inhibitor
Inhibits transport of H+ ions into the stomach by forming bonds at H+/K+ ATPase

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4
Q

Buprenorphine Classification

A

Opioid
Partial Mu agonist, Kappa antagonist

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5
Q

Dexmedetomidine MOA

A

alpha-2 antagonist
- will decrease synaptic release of norepinephrine
- biphasic cardiovascular response of initial hypertension before hypotension

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6
Q

Benzodiazepine MOA

A

Potentiation of GABA - hyperpolarizes cells, making it more difficult to depolarize and excite

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7
Q

Diazepam MOA

A

benzodiazepine
longer duration of action than Midaz - so preferred in emergency situations

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8
Q

Propofol MOA

A

GABA agonist

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9
Q

Isoflurane

A
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10
Q

Carprofen MOA

A

COX2 inhibitor NSAID

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11
Q

Lidocaine MOA

A

inhibits initiation and conduction of action potentials by blocking voltage-gated sodium channels
- local anesthetic

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12
Q

Metronidazole MOA

A

DNA synthesis disruption

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13
Q

Metronidazole Classification

A

BacteriCIDAL
Activity against most obligate anaerobes

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14
Q

Metronidazole ADME

A

A: oral bioavailability high, absorption enhanced with food
D: LIPOphilic - widely distributed
M: liver
E: metabolites and unchanged drug in urine and feces

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15
Q

Dexmethasone

A

Glucocorticoid
- long acing, rapid onset

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16
Q

Prednisone

A

Glucocorticoid

17
Q

Trilostane MOA

A

adrenal steroid synthesis inhibitor
competitive inhibitor of 3-Beta hydroxysteroid deoxyhydrogenase

18
Q

DOCP Classification

A

Mineralocorticoid

19
Q

Fludrocortisone Classification

A

Mineralocorticoid (primarily
Has SOME glucocorticoid activity

20
Q

Hydrocortisone Classification

A

1:1 mineralocorticoid AND glucocorticoid

21
Q

Glucocorticoid EFFECTS

A
  • gluconeogenesis
  • immune suppression via inhibition of leukocyte trafficking
  • increase secretion of gastric acid, pepsin, and trypsin
  • lipolysis

Block 6 (7 decks)

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