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Block 6 > VBS 4 Pharm > Flashcards

VBS 4 Pharm Flashcards

1
Q

Radioactive Iodine (I-131) MOA

A
  • I-131 IV admin
  • emitted radiation destroys surrounding functioning follicular cells
  • minimal damage to bordering structures
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2
Q

Atenolol Classification

A
  • B1-adrenergic antagonist (Beta blocker)
  • Class II antiarrythmic
  • negative ionotroph
  • negative chronotroph
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3
Q

Atenolol MOA

A
  • binds to B1 receptors in the heart
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4
Q

Methimazole MOA

A
  • anti-thyroid: inhibits thyroid peroxidase
  • dose-dependent
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5
Q

Propofol MOA

A
  • decreases the rate of GABA dissociation from receptors
  • enhances opening of Cl channels
  • resulting in hyperpolarization of postsynaptic cell membranes and inhibition of postsynaptic neurons
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6
Q

Alfaxalone MOA

A
  • binds to GABA cell surface receptors
  • enhances opening of Cl channels
  • resulting in hyperpolarization of postsynaptic cell membranes and inhibition of postsynaptic neurons
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7
Q

Enrofloxacin Classification

A
  • fluoroquinolone antibiotic
  • bacteriCIDAL
  • concentration-dependent
  • highly effective against Gram- aerobes, some Gram+ aerobes
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8
Q

Enrofloxacin MOA

A

inhibits DNA gyrase (facilitates DNA replication or transcription)

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9
Q

Enrofloxacin Adverse Effects

A
  • cats: actue retinal degeneration
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10
Q

Silver Sulfadiazine Classification

A
  • sulfonamide antibiotic
  • bacteriCIDAL
  • Broad spectrum: Gram+/- bacteria, yeast/fungal infections
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11
Q

Sulfonamides MOA

A
  • disrupts cell wall and membrane
  • inhibition of DNA replication
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12
Q

Amikacin Classification

A
  • aminoglycoside antibiotic
  • treats serious Gram- infections
  • bacteriCIDAL
  • concentration dependent
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13
Q

Amikacin MOA

A

irreversibly binds 30S ribosomal unit - inhibiting protein synthesis

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14
Q

Amikacin Adverse Effets

A
  • OTOtoxicity (8th cranial nerve lol)
  • nephrotoxicity
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15
Q

Meloxicam MOA

A
  • NSAID: COX-2 preferential (NOT specific!)
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16
Q

Calcium Gluconate MOA

A
  • given in the form of complexes for hypocalcemia
  • essential element required for many functions ok cool
17
Q

Povidone-Iodine solution (betadine) Classification

A
  • iodophore antiseptic
  • bacteriCIDAL
  • spectrum against Gram+/- bacteria
18
Q

Povidone-Iodine solution (betadine) MOA

A
  • slowly releasing iodine to tissues
  • since small molecule, iodine rapidly penetrates into microorganisms and oxidizes proteins, nucleotides, and fatty acids —> leading to cell death
19
Q

Chlorhexidine Diacetate Classification

A
  • biguanide broad spectrum antiseptic
  • bacteriCIDAL (at high conc.), bacteriSTATIC (at low conc.)
  • concentration dependent
  • longer residual activity
  • better activity against Gram+ > Gram-
20
Q

Isofluorane MOA

A
  • rapidly absorbed from alveoli because of LOW blood solubility (blood gas partition coefficient)

Block 6 (7 decks)

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