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VI - Neoplasia Flashcards

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1
Q

Pathology Flashcards

This term literally means “new growth”.

A

Neoplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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2
Q

Pathology Flashcards

An abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the same excessive manner after the cessation of stimuli which evoked the change.

A

Neoplasm(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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3
Q

Pathology Flashcards

Study of tumors.

A

Oncology(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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4
Q

Pathology Flashcards

Benign or malignant?Localized

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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5
Q

Pathology Flashcards

Benign or malignant?Amenable to surgical removal

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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6
Q

Pathology Flashcards

Benign or malignant?Invades and destroys adjacent tissues.

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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7
Q

Pathology Flashcards

What are the two basic components of tumors?

A

Parenchyma and Stroma(TOPNOTCH)

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8
Q

Pathology Flashcards

Benign or malignant?Metastasis

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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9
Q

Pathology Flashcards

This component of tumors largely determines its biologic behavior.

A

Parenchyma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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10
Q

Pathology Flashcards

This component of tumors determines the name of the growth.

A

Parenchyma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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11
Q

Pathology Flashcards

This component of tumors is crucial to the growth of neoplasms since it carries the blood supply and provides support to the growth of cells.

A

Stroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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12
Q

Pathology Flashcards

Benign or malignant?Fibroma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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13
Q

Pathology Flashcards

Benign or malignant?Chondroma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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14
Q

Pathology Flashcards

Benign or malignant?Adenoma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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15
Q

Pathology Flashcards

Benign or malignant?Hepatoma

A

Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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16
Q

Pathology Flashcards

Benign or malignant?Papilloma

A

Benign(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176

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17
Q

Pathology Flashcards

Malignant neoplasms arising in mesenchymal tissue or its derivatives.

A

Sarcomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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18
Q

Pathology Flashcards

Benign tumor arising in fibrous tissue is called?

A

Fibroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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19
Q

Pathology Flashcards

A benign cartilagenous tumor is called?

A

Chondroma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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20
Q

Pathology Flashcards

This is a benign epithelial neoplasm which produces glandular patterns or neoplasms derived from glands but not necessarily exhibit glandular patterns

A

Adenoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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21
Q

Pathology Flashcards

These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds.

A

Papillomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.174

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22
Q

Pathology Flashcards

A mass that projects above a mucosal surface to form a macroscopically visible structure.

A

Polyps(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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23
Q

Pathology Flashcards

A cancer of fibrous tissue origin.

A

Fibrosarcoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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24
Q

Pathology Flashcards

Malignant neoplasms of epithelial cell origin.

A

Carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.175

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25
# Pathology Flashcards Carcinoma of squamous cell origin.
Squamous cell carcinoma(TOPNOTCH)
26
# Pathology Flashcards Carcinoma of squamous cell origin.
Squamous cell carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
27
# Pathology Flashcards Benign or malignant?Lymphoma
Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
28
# Pathology Flashcards Benign or malignant?Seminoma
Malignant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
29
# Pathology Flashcards The extent to which neoplastic cells resemble their normal forebears morphologically and functionally.
Differentiation(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.176
30
# Pathology Flashcards This is considered a hallmark of malignancy, which literally means "to form backward".
Anaplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.177
31
# Pathology Flashcards These cells display marked pleomorphism, nuclei are variable and bizzare in size and shape. Chromatin is course and clumped. Mitoses are often numerous and distinctly atypical.
Anaplastic cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.177
32
# Pathology Flashcards This term is defined by disorderly but non-neoplastic proliferation of cells, described as a loss in uniformity of individual cells and in their architectural orientation.
Dysplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
33
# Pathology Flashcards Defined as dysplactic changes which involve the entire thickness of the epithelium.
Carcinoma -in - situ(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
34
# Pathology Flashcards True or false?Dysplasia always progress to cancer.
False(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.178
35
# Pathology Flashcards True or false?Lack of capsule in a neoplastic growth indicates malignancy.
FalseSome benign tumors are not encapsulated.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
36
# Pathology Flashcards This term describes the development of secondary implants discontinuous with the primary tumor, in remote tissues.
Metastasis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
37
# Pathology Flashcards Next to metastasis, this is the most reliable feature that distinguishes malignant from benign tumors.
Local invasiveness(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.179
38
# Pathology Flashcards Methods of dissemination of malignant neoplasms? (3)
SeedingLymphatic spreadHematogenous spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
39
# Pathology Flashcards This is the mode of dissemination of cancers of the ovary and CNS.
Spread by seeding(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
40
# Pathology Flashcards This is the mode of dissemination more typical of carcinomas.
Lymphatic spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
41
# Pathology Flashcards This is the mode of dissemination more typical of sarcomas.
Hematogenous spread(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
42
# Pathology Flashcards It is defined as the first lymph node in a regional lymphatic basin that receives lymph flow from a primary tumor.
Sentinel lymph node(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.180
43
# Pathology Flashcards What are the most common sites of metastasis involved in hematogenous dissemination of cancer?
Liver and lungs(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.181
44
# Pathology Flashcards This substance is a byproduct of metal smelting, a component of alloys, electrical and semiconductor devices which could cause cancer of the lungs and skin and hemangiosarcomas.
Arsenic and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
45
# Pathology Flashcards This substance was formerly used for fire-resistant textiles and construction materials which could cause lung cancer and more prominently malignant mesothelioma
Asbestos(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
46
# Pathology Flashcards This substance is commonly used as a solvent in paint, rubber, dry cleaning, adhesives and detergents which could cause leukemias and Hodgkin lymphoma.
Benzene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
47
# Pathology Flashcards This substance is used as hardener for metal alloys used in aerospace applications and nuclear reactors which is commonly associated with cancer of the lung.
Beryllium and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
48
# Pathology Flashcards This substance is used in solders, batteries and metal alloys commonly associated with cancers of the prostate.
Cadmium and its compounds(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
49
# Pathology Flashcards This substance is a refrigerant and used as adhesive for plastics, which causes hepatic angiosarcoma.
Vinyl chloride(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.183
50
# Pathology Flashcards Inherited gene : Cancer syndromeRB gene :__________
Retinoblastoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
51
# Pathology Flashcards Inherited gene : Cancer syndromep53 : ______________
Li Fraumeni Syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
52
# Pathology Flashcards Inherited gene : Cancer syndrome__________ : Familial Adenomatous Polyposis / Colon CA
APC Gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
53
# Pathology Flashcards Inherited gene : Cancer syndrome_________ : Breast on Ovarian Tumors
BRCA 1 gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
54
# Pathology Flashcards Inherited gene : Cancer syndrome_________ : Breast Cancer only
BRCA 2 gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
55
# Pathology Flashcards Inherited gene : Cancer syndromeRET gene : _________
Multiple Endocrine Neoplasia 1 and 2(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
56
# Pathology Flashcards Inherited gene : Cancer syndrome__________ : Colon cancer
kras gene(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.184
57
# Pathology Flashcards Normal cellular genes whose products promote cell proliferation.
Proto-oncogenes(TOPNOTCH)
58
# Pathology Flashcards Normal cellular genes whose products promote cell proliferation.
Proto-oncogenes(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.188
59
# Pathology Flashcards It is a naturally occurring carcinogenic agent produced by some strains of Aspergillus, a mold that grows on improperly stored grains and nuts.
Aflatoxin B(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
60
# Pathology Flashcards There is a strong correlation between the dietary level of Aflatoxin and what type of cancer?
Hepatocellular Carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
61
# Pathology Flashcards These substances require metabolic conversion to be carcinogenic.
Indirect - acting carcinogens(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.209
62
# Pathology Flashcards These substances stimulate proliferation of the mutated cells.
Promoters(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
63
# Pathology Flashcards How does ionizing radiation cause cancer?
Through chromosome breakage, translocations and point mutations leading to genetic damage and carcinogenesis.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
64
# Pathology Flashcards What is the mechanism of action of UV rays in the formation of neoplastic cells?
UV rays induce formation of pyrimidine dimers within DNA leading to mutations.(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.210
65
# Pathology Flashcards This is the only retrovirus that has been demonstrated to cause cancer in humans.
Human T-cell Leukemia Virus -1 (HTLV-1)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.211
66
# Pathology Flashcards HPV strains which has been implicated in the genesis of cervical and anorectal cancer.
HPV 16, 18(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.212
67
# Pathology Flashcards EBV has been implicated in the pathogenesis of the following cancers except:A. Burkitt lymphomaB. Lymphoma in HIV patientsC. Nasopharyngeal carcinomaD. Hodgkin lymphomaE. None of the above
E. none of the above(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.212
68
# Pathology Flashcards Which hepatitis virus leads to hepatocellular carcinoma?
HBV, HCV(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.213
69
# Pathology Flashcards This is the first bacterium to be classified as a carcinogen.
Helicobacter pylori(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.213
70
# Pathology Flashcards What type of cancer can be caused by H.pylori?
Gastric adenocarcinoma Gastric MALT lymphomas(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.214
71
# Pathology Flashcards These are benign epithelial neoplasms, growing on any surface that produce microscopic or macroscopic finger-like fronds.
Papillomas(TOPNOTCH)
72
# Pathology Flashcards Tumor antigens are presented on the cell surface by MHC Class I molecules to which type of T lymphocytes?
CD8+ T lymphocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed p.215

Pathology Flashcards (23 decks)

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