VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

Pharmacology > VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs > Flashcards

Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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31

Interferes with a late stage in cell wall synthesis in gram + organisms ; For gram + bacteria

Bacitracin (TOPNOTCH)

32

Reserved for topical use only due to marked nephrotoxicity

Bacitracin (TOPNOTCH)

33

Blocks incorporation of D-Ala into the pentapeptide side chain of the peptidoglycan ; For drug-resistant TB

Cycloserine (TOPNOTCH)

34

inhibits cytosolic enolpyruvate transferase --> prevents formation of N-acetylmuramic acid

Fosfomycin (TOPNOTCH)

35

same spectrum of activity as Vancomycin ; For VRE, VRSA, for G+ activity, against endocarditis and sepsis

Daptomycin (TOPNOTCH)

36

Inhibits transpeptidation (catalyzed by peptidyl transferase) by blocking the binding of aminoacyl moiety of the charged tRNA to the acceptor site o mRNA at 50S subunit, basteriostatic

Chloramphenicol (TOPNOTCH)

37

For meningitis (Strep pneumonia, H influenza, Neisseria meningitides), back up for Salmonella, Rickettsia, Bacteroides, Wide spectrum antibiotic

Chloramphenicol (TOPNOTCH)

38

Binds 30s ribosomal subunit thus preveting the binding of tRNA to mRNA, bacteriostatic ; Broad/Wide Spectrum (G+ and G-), anaerobes and atypicals

Tetracyclines (TOPNOTCH)

39

_____ has the broadest spectrum of all tetracyclines and has the longest t1/2 (30-36hrs)

Tigecycline (TOPNOTCH)

40

SE: GI disturbances (enetrocolitis, nausea, diarrhea, vomiting), teratogen (tooth enamel dysplasia/discoloration), hepatotoxicity, nephrotoxicity, photosensitivity n(esp. demeclocycline), vestibulotoxicity, candidiasis, bacterial superinfection with S. aureus and C. difficile, Fanconi syndrome

Tetracyclines (TOPNOTCH)

41

Tetracyclines

Tetracycline, doxycycline, minocycline, tigecycline, demeclocycline (TOPNOTCH)

42

Binds 30s ribosomal subunit, inhibit transpeptidation, bacteriostatic ; For community-acquired pneumonia, pertussis, diphtheria, chlamydial infections

Macrolides (TOPNOTCH)

43

Macrolides

Erythromycin, azithromycin, clarithromycin, telithromycin (TOPNOTCH)

44

______ is used as an alternative Ceftriaxone in Gonorrhea and to Pen G in syphilis

Azithromycin (TOPNOTCH)

45

______ is used for macrolide-resistance

telithromycin (TOPNOTCH)

46

a narrow spectrum macrolide, for G+ and anaerobe, low oral bioavailability

Fidaxomicin (TOPNOTCH)

47

as effective as Vancomycin as treatment for C. difficile possibly with lower relapse rate

Fidaxomicin (TOPNOTCH)

48

GI disturbance, skin rash, neutropenia, hepatic dysfunction, possible superinfection (Pseudomembranous colitis - C. difficile overgrowth)

Lincosamides: Clindamycin, lincomycin (TOPNOTCH)

49

Binds 30s ribosomal subunit, inhibit transpeptidation, bacteriostatic ; For anaerobic infections (Bacteroides), alternative against gram + cocci (MRSA), endocarditis prophylaxis esp in those allergic to Pens, PCP pneumonia, toxoplasmosis (+ Pyrimethamine), skin and soft tissue infection

Lincosamides: Clindamycin, lincomycin (TOPNOTCH)

50

Binds 50s ribosomal subunit, constricting the channel where polypeptides are extruded thus tRNA synthetase is also inhibited --> decreased free tRNA

Streptogramin: Quinupristin-Dalfopristin (TOPNOTCH)

51

Binds 23S rRNA of 50s ribosomal subunit, inhibit initiation by blockin formation of the tRNA-ribosome-mRNA ternary complex, bacteriostatic ; Reserved for infections caused by drug-resistant gram + cocci (MRSA, VRE, PRSP), Listeria, Corynebacteria

Oxazolidinone: Linezolid (TOPNOTCH)

52

For serious infections caused by aerobic gram _ bacteria (E.coli, Enterobacter, Klebsiella, Proteus, Providencia, Pseudomonas, Serratia, Haemophilus, Moraxella, Shigella), endocarditis, ocular infections

Aminoglycosides (TOPNOTCH)

53

Least resistance and narrowest therapeutic window ; used for streptomycin-resistant TB

Amikacin (TOPNOTCH)

54

For TB, tularaemia, bubonic plague, brucellosis

Streptomycin (TOPNOTCH)

55

SE: nephrotoxicity (reversible), ototoxicity (irreversible), neuromuscular blockade

Aminoglycosides in general (TOPNOTCH)

56

SE: hypersensitivity, nephrotoxicity (reversible), ototoxicity (irreversible), neuromuscular blockade, teratogen (congenital deafness), injection site reactions

Streptomycin (TOPNOTCH)

57

_____ is most ototoxic of all Aminoglycosides (AG) while _____ has the most skin reactions

kanamycin ; Neomycin (TOPNOTCH)

58

For drug-resistant gonorrhoea, gonorrhoea in penicillin allergic patients

Spectinomycin (TOPNOTCH)

59

For Treatment of serious infections caused by organisms resistant to other aminoglycosides

Netilmicin (TOPNOTCH)

60

Inhibits dihydropteroate synthase, bacteriostatic

Sulfonamides (TOPNOTCH)