VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

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Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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61

low solubility in acidic urine causing formation of stones

Sulfonamides (TOPNOTCH)

62

Sequential blockade of dihydropteroate synthase and dihydrofolate reductase , bactericidal

Co-trimoxazole (Sulfamethoxazole + Trimethoprim) (TOPNOTCH)

63

SE: GI upset, acute hemolysis in G6PD deficiency, nephrotoxicity, hypersensitivity, hematotoxicity, kernicterus ; antifolate effects (megaloblastic anemia, leukopenia, granulocytopenia)

Co-trimoxazole (Sulfamethoxazole + Trimethoprim) (TOPNOTCH)

64

Inhibits DNA replication by binding to DNA gyrase and topoisomerase IV (G+) and Topoisomerase II (G-)

Fluoroquinolones (TOPNOTCH)

65

For infections of the urogenital and GI tract by G- (gonococci, E. coli, Klebsiela, Campylobacter, Enterobacter, Pseudomonas, Salmonella, Shigella), respiratory tract, skin and soft tissue infection

Fluoroquinolones (TOPNOTCH)

66

CI in pregnancy and in children (damage growing cartilage --> arthropathy)

Fluoroquinolones (TOPNOTCH)

67

GI distress, skin rashes, HA, dizziness, insomnia, increased LFT, phototoxicity, CNS effects (dizziness, headache), tendinitis and tendon rupture, opportunistic infection by Candida and Streptococci

Fluoroquinolones (TOPNOTCH)

68

Second Generation Fluoroquinolones

Ciprofloxacin, ofloxacin (TOPNOTCH)

69

First Generation Fluoroquinolones

Norfloxacin, Nalidixic acid (TOPNOTCH)

70

Third Generation Fluoroquinolones

Levofloxacin, Gemifloxacin, Moxifloxacin (TOPNOTCH)

71

Respiratory Quinolones

Levofloxacin, Gemifloxacin, Moxifloxacin (TOPNOTCH)

72

newest members of the Fluoroquinolone family and are condisered to have the broadest spectrum of activity with increased activity aginst anaerobes ang atypical agents

Moxifloxacin and Gemifloxacin (TOPNOTCH)

73

Fourth Generation Fluoroquinolones

Trovafloxacin, Gatifloxacin (TOPNOTCH)

74

FQ elimination is via kidneys by tubular secretion (may compete with probenecid for excretion) EXCEPT

Moxifloxacin (TOPNOTCH)

75

additional SE of which FQs: diabetes, hepatotoxicity

diabetes (gatifloxacin), hepatotoxicity (trovafloxacin) (TOPNOTCH)

76

Reactive reduction by ferredoxin forming free radicals that disrupt electron transport chain, bactericidal

Metronidazole, tinidazole (TOPNOTCH)

77

For anaerobic or mixed intra-abdominal infections, vaginitis (trichomonas, gardnerella), pseudomembranous colitis, brain abscess, protozoal infections

Metronidazole, tinidazole (TOPNOTCH)

78

DOC for amoebiasis, giardiasis and Pseudomembranous colitis

Metronidazole (TOPNOTCH)

79

single OD dose can prevent recurrent UTI

Nitrofurantoin (TOPNOTCH)

80

SE: GI irritation, metallic taste, headache, dark urine, leukopenia, dizziness, ataxia, neuropathy, seizures and disulfiram reaction

Metronidazole (TOPNOTCH)

81

acidification of urine enhances activity ; adjust dose in renal patients

Nitrofurantoin (TOPNOTCH)

82

Forms multiple reactive intermediates when acted upon by bacterial nitrofuran reductase, bactericidal ; For UTI (except Proteus and Pseudomonas)

Nitrofurantoin (TOPNOTCH)

83

Inhibits mycolic acid synthesis, bactericidal

Isoniazid (TOPNOTCH)

84

SE: hepatotoxicity, neurotoxicity (seizures, peripheral neuritis, insomnia, restlessness, muscle twitching), acute hemolysis in G6PD deficiency, drug-induced lupus

Isoniazid (TOPNOTCH)

85

Most impt drug in TB

Isoniazid (TOPNOTCH)

86

prevent neurotoxicity of Isoniazid by giving

pyridoxine (vit B6) (TOPNOTCH)

87

given as a sole drug for prophylaxis of close contacts of TB Px and skin test converters

Isoniazid (TOPNOTCH)

88

Inhibits DNA-dependent RNA polymerase, bactericidal

Rifamycin derivatives: Rifampicin, rifabutin, rifapentine, rifamixin (TOPNOTCH)

89

red-orange urine, light chain proteinuria, skin rash, thrombocytopenia, nephritis, hepatotoxicity, flulike syndrome, anemia, impair antibody response

Rifamycin derivatives: Rifampicin, rifabutin, rifapentine, rifamixin (TOPNOTCH)

90

CYP450 inhibitor: Rifampicin or INH

INH (TOPNOTCH)