VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Preview

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Flashcards in VII - Topnotch Pharma Flash Cards - Chemotherapeutic Drugs Deck (225)
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121

Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase, guanosine analog, competitive substrate for DNA polymerase, causes chain termination after its incorporation into the viral DNA

Acyclovir, valacyclovir, penciclovir, famciclovir, docosanol (TOPNOTCH)

122

For infections due to HSV1, HSV2, VZV (mucocutaneous and genital herpes, prophylaxis in AIDS and in other Immunocompromised states such as organ transplant patients, herpes encephalitis, neonatal HSV infection etc.

Acyclovir, valacyclovir, penciclovir, famciclovir, docosanol (TOPNOTCH)

123

_____ is a prodrug that is converted to Acyclovir and reached plams levels 3-5x (longer t1/2) more than acyclovir

Valacyclovir (TOPNOTCH)

124

____ is a prodrug which is converted to Penciclovir in vivo

Famciclovir (TOPNOTCH)

125

Inhibits fusion between the HSV envelope and plasma membrane, prevents viral entry and subsequent replication

Docosanol (TOPNOTCH)

126

Inhibits viral DNA polymerase causing chain termination, guanosine derivative

Ganciclovir, valganciclovir (TOPNOTCH)

127

For infections due to CMV, HSV1, HSV2, VZV ; For prohylaxis and treatment of CMV retinitis and other CMV infections in the immunocompromised patients

Ganciclovir, valganciclovir (TOPNOTCH)

128

Inhibits viral DNA polymerase causing chain termination ; For CMV retinitis, mucocutaneous HSV infections, acyclovir-resistance, ganciclovir-resistance, genital warts and molluscum contangiosum

Cifodovir (TOPNOTCH)

129

Inhibits viral RNA polymerase, DNA polymerase, and HIV reverse transcriptase, binds to pyrophosphate binding site

Foscarnet (TOPNOTCH)

130

adenine analog ; For HSV, VZV, CMV

Vidarabine (TOPNOTCH)

131

pyrimidine analogs ; For herpes keratitis (HSV-1)

Idoxuridine, trifluridine (TOPNOTCH)

132

antisense oligonucleotide that binds to mRNA of CMV causing inhibition of early protein synthesis ; For CMV retinitis

Fomivirsen (TOPNOTCH)

133

Inhibit HIV reverse transcriptase after phosphorylation by cellular enzymes, acts as chain terminators via insertion into the growing DNA chain

NRTI (TOPNOTCH)

134

NRTIs

Abacavir, Didanosine (ddI), Emtricitabine, Lamivudine (3TC), Stavudine (d4T), Tenofovir, Zalcitabine (ddC),Zidovudine (ZDV) (TOPNOTCH)

135

Inhibits HIV reverse transcriptase, no phosphorylation required, do not compete with nucleoside triphosphate

NNRTI (TOPNOTCH)

136

NNRTIs

Delavirdine, efavirenz, etravirine, nevirapine (TOPNOTCH)

137

cleaves precursor polyprotein to form the final structural protein of the mature virion core, inhibits viral protein processing

Protease Inhibitor (TOPNOTCH)

138

Protease Inhibitor

Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir-Ritonavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir (TOPNOTCH)

139

Binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes

Fusion Inhibitor: Enfuvirtide (TOPNOTCH)

140

Blocks viral attachment by blocking CCR5, a transmembrane protein involved in the attachment of HIV to host cell

CCR5 receptor antagonist: Maraviroc (TOPNOTCH)

141

Inhibit early step replication and prevent uncoating by binding to M2 proton channels ; For influenza A and rubella

Uncoating inhibitors: Amantadine, rimantadine (TOPNOTCH)

142

Inhibits neuraminidase which cleaves sialic acid residues from viral proteins and surface proteins of infected cells , decrease release of progeny virus

Neuraminidase inhibitors: Oseltamivir, zanamivir (TOPNOTCH)

143

DOC for influenza (including H1N1)

Neuraminidase inhibitors: Oseltamivir, zanamivir (TOPNOTCH)

144

cytokine, increased activity of JAKS leading to phosphorylation of signal transducers and activation of transcription (STATS) which causes increased formation of antiviral proteins

Interferon (TOPNOTCH)

145

For chronic HBV, HCV infection, Kaposi sarcoma, genital warts, prevents dissemination of HZV in cancer patients and decreased CMV shedding after renal transplantation

Interferon (TOPNOTCH)

146

Inhibits HBV DNA polymerase causing chain termination after incorporation into the viral DNA

Adefovir, Dipivoxil, Telbivudine, Tenofovir (TOPNOTCH)

147

______ is a prodrug of Adefovir

Dipiroxil (TOPNOTCH)

148

_____is an anti-RT drug that is also effective in chronic HBV, it is active against lamivudine and entecavir-resistant strains

Tenofovir (TOPNOTCH)

149

guanosine nucleoside, inhibits DNA polymerase

Entecavir (TOPNOTCH)

150

Coinfection between HBV and HIV may increase the risk of pancreatitis with_____use

lamivudine (TOPNOTCH)